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The map label for this gene is hutH [H]

Identifier: 170022339

GI number: 170022339

Start: 86571

End: 88103

Strand: Direct

Name: hutH [H]

Synonym: YPK_0077

Alternate gene names: 170022339

Gene position: 86571-88103 (Clockwise)

Preceding gene: 170022338

Following gene: 170022340

Centisome position: 1.85

GC content: 50.75

Gene sequence:

>1533_bases
ATGAAGACAATAACACTACGTCCTGGTCAGATGACGCTGGCTGACTTACGGCATATTTATCAACATCCCGTACATATCAC
ATTGGATGAAAGTGCCTATGTACCCATTCAGCAAAGTGTGGATTGTGTGCAAGCCATATTGGCAGAACAGCGCACGGCAT
ATGGCATTAACACTGGGTTTGGCTTGCTGGCCTCTACCCGTATCGCCACCGAAGACTTGGAAAACTTACAGCGCTCAATC
GTACTCTCTCACGCGGCAGGAGTCGGAGAAGCGAATGATGATGCGATTGTGCGTCTGATTATGGTGCTGAAAATCAATAG
CCTGGCGAGAGGTTTCTCAGGTATTCGGCTGGAGGTGATTCAGGCGCTGATTACCTTGGTCAATGCTGGGGTTTATCCGC
ATATCCCGTTAAAAGGATCAGTGGGCGCTTCTGGCGATTTAGCTCCGCTGGCACATATGAGCTTGCTGCTATTAGGTGAA
GGAAAAGCCCGCTATCAGGGTGAATGGTTGCCCGCACACACGGCACTGGCGCAAGCGGGTTTGCAGCCCCTCACACTGGC
GGCGAAAGAGGGTTTGGCACTACTTAACGGCACCCAGGTCTCTGCCGCTTATGCATTGCGTGGTTTATTTGAGGCCGAAG
ATCTCTATGCGGCCGCTTCGGTGTTTGGCTGCCTGACAGTGGATGCAGCATTAGGATCCCGTAGCCCATTTGACGCCCGT
ATTCACGCCGTTCGGGGCCAACGTGGGCAGATTGATGCTGCCAGCACTTATCGTCATCTGCTTGGTGAACGCAGTGAAAT
CTCAGAATCACACAAGAATTGTGACAAAGTGCAGGATCCATATTCTTTACGCTGTCAGCCACAGGTGATGGGCGCATGTT
TAGGCCAAATACGTCAGGCGGCAGAGGTGCTGGCTATTGAATCCAATGCCGTTTCAGATAACCCGTTGGTGTTTGCTGAA
CAGGGTGATGTCTTGTCTGGTGGGAATTTCCATGCTGAACCGGTCGCTATGGCAGCAGATAATCTGGCGTTGGCGTTGGC
AGAAATCGGTTCATTATCAGAGTGCCGTATCTCGTTGATGATGGACAAGCATATGTCTCAGTTACCTCCATTTCTGGTAG
AGAACGGTGGCGTAAATTCTGGCTTTATGATTGCTCAGGTTACGGCTGCGGCGTTAACCAGTGAAAATAAAGGGCTGGCA
TTCCCCGCCAGTGTCGATAGCATCCCAACATCTGCTAATCAGGAAGATCATGTCTCTATGGCCCCTCGGGCGGGTAAACG
CTTGTGGGAAATGGCTGAAAATGTACGGAATATACTGGCTATCGAGTGGCTGGCTGCGTGTCAGGGGCTTGATTTGCGCA
AAGGGCTAAGAACTTCCGCCATACTGGAGCCCGCCCGCCAACTATTACGCCAGCACGTCACTTACTACGATAAAGATCGT
TTCTTTGCCCCCGATATTGAAGTTGCTAGCCAGCTTATTGCACAACGTCATATGAATGAGTTGATGCCAGCAAAATTACT
GCCAAGTCTTTAA

Upstream 100 bases:

>100_bases
TGATGCGCCATGCAGATGCGGGTTATGACATTGCGGTTAACTGCGCGCAAGAGCAAGGACTTAACCTACCAATGGTTGCC
GCAACTCAGGGGAAAAAATC

Downstream 100 bases:

>100_bases
TAACAATAGTTTTCCAAGACAGTCATTTCCCAAGGCAGCAGTTTCCAAATACAGCAGTTTCCCAAGACAGTCGTTTCCAA
AGAAATTGGCGTTGCAGACA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEIGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL

Sequences:

>Translated_510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEIGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
>Mature_510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEIGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=43.8492063492063, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567831, Length=469, Percent_Identity=42.8571428571429, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54842; Mature: 54842

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00488 PAL_HISTIDASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGF
CCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
GLLASTRIATEDLENLQRSIVLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
QALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGEGKARYQGEWLPAHTALAQAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHCC
LQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQA
HHEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIESNAVSDNPLVFAEQGDVLSGGNFHAEPVAMAADNLALALAEIGSLSECRISLM
HHHHEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLAFPASVDSIPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
APRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCEECCCC
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
CCCCCHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGF
CCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
GLLASTRIATEDLENLQRSIVLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
QALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGEGKARYQGEWLPAHTALAQAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHCC
LQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQA
HHEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIESNAVSDNPLVFAEQGDVLSGGNFHAEPVAMAADNLALALAEIGSLSECRISLM
HHHHEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLAFPASVDSIPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
APRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCEECCCC
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
CCCCCHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]