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The map label for this gene is 169630953

Identifier: 169630953

GI number: 169630953

Start: 3925271

End: 3926782

Strand: Reverse

Name: 169630953

Synonym: MAB_3874c

Alternate gene names: NA

Gene position: 3926782-3925271 (Counterclockwise)

Preceding gene: 169630955

Following gene: 169630952

Centisome position: 77.49

GC content: 63.43

Gene sequence:

>1512_bases
ATGACCGCCACAGCTCAACCAGCCGCCAGCACAAGCCCGTACTTGTCCGGGATCTGGGAGCCTGTCCAGCAGGAAATGGA
CAGCGTCGACCTCGAGGTGACCGGCACCTTGCCCGCGCATCTGGATGGCAGATATCTGCGCAACGGCCCCAACCCGGCGG
CAGAGGTCGACCCGGCCACGTATCACCTCTTCAGTGGCGATGCCATGGTGCACGGGTTGTCGCTGCGCGAGGGCAAGGCG
CAGTGGTACCGCAACCGCTGGGTGCGCACCCCATCGGTGAGTAAGACGTTGGGTGAGACCCGTCCGGCCGCTATCAGCGC
GAATGCGGGCATGGGAGTCATCGGGCCGAACACCAACGTGCTGGGCCACGCCGGACGCACGCTCGCCCTCGTCGAAGGGG
GGATCGCCAATTACGAACTCACCGAAGACCTCGACACCATCGGAACCTGCGATTTCGATGGCACCCTCCCCGGCGGGTAC
ACCGCCCACCCGCACACCGATCCAGATACCGGTGAAATGCACGCCGTCTCATACTCTTTCGCCCGTGGCAGCACGGTTCA
GTACTCGGTGATCGACGCCCATGGCCGTGCCCGCCGCACTGTCGACATCCCGGTGCACGGCGCGCCGATGATGCATGACT
TCACCCTCACCGAGAAGTACGTCGTTTTCTACGATCTGCCGGTCACCTTGGACATGTCGATGATCAGCCAGTCGGTGCCA
GTGCCACGGCTGCTGCGCAAGCCCGCTCAGATCGTGATGAACTCGCTTATCGGCAAGGTTAAGATTCCCGGCCCCATCGC
GGCCAAGGCCAGTCAGTACTCGGGCAAGTCGCCGTCCATTCCGTATTCGTGGAACCCCAAGTACCCGGCCAGAATCGGTG
TCATGCCGCGCGAGGGCGATGACGCCTCCCGGCACGCCCCCGTGCGCTGGTTCGAGATCGACCCGTGCTACGTCTTCCAT
CCGCTCAACGGGTACTCCGAAATGCGCAACGGTGCGGAGGTCATCGTGATCGACCTCGTGCGGTATGACTCGATGTTCTC
CCAGGACGTGCTGGGACCCAGCGATGCCAAGGGTCAGTTGGATCGCTGGACGATCGACCTCGCCAAGGGCACCGTGCATA
TGGAACGCAAGGACGACAGGCACCTGGAATTCCCGCGAATCAACGAGACTTTCACGGGCAAGAAGCACCGCTACGGCTAT
CTGCCGGATGTCGAGAACTTCTTCGGCTCCGGAGAAGCGGCGGGGGCGAGCATCGTCAAATACGACTACGAGACCGGATC
TACCCTCTCAAGCCGGCTGGACCCCGCAATCGTGCTGGGGGAGATGTCATTCGTGCCGAATCCGACGTGTGCCGCCGAGG
ACGACGGTGTGCTCATCGGGTTTGCCGTCGACCGCCGGTCCGATGAGGGGCAGTTGCTGCTGCTCGATGCGACCAGCCTG
GATCTCATGGCCACCGTCCATCTGCCGCAGCGAGTTCCGGCAGGCTTCCACGGCAACTGGGCTCCGCGCTGA

Upstream 100 bases:

>100_bases
GGCAGATGAACTCATGGTCTTGCCATGTTCGCACAACGGGAGTACGTTCACCATAACACTGTAATAACAGTGTTATGCCA
GCCAGCTCTTGGAGGACGCG

Downstream 100 bases:

>100_bases
GATCGTGATCGGTCCTGGTGACACTTCAGGCACGGGGCTGTCGGTAAATCGTCGCGGAAACTCGTCGGCGGCCGTCACAC
TCGTGGCATGGAGATCACGT

Product: putative dioxygenase

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKA
QWYRNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEGGIANYELTEDLDTIGTCDFDGTLPGGY
TAHPHTDPDTGEMHAVSYSFARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVP
VPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFH
PLNGYSEMRNGAEVIVIDLVRYDSMFSQDVLGPSDAKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGY
LPDVENFFGSGEAAGASIVKYDYETGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSL
DLMATVHLPQRVPAGFHGNWAPR

Sequences:

>Translated_503_residues
MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKA
QWYRNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEGGIANYELTEDLDTIGTCDFDGTLPGGY
TAHPHTDPDTGEMHAVSYSFARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVP
VPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFH
PLNGYSEMRNGAEVIVIDLVRYDSMFSQDVLGPSDAKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGY
LPDVENFFGSGEAAGASIVKYDYETGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSL
DLMATVHLPQRVPAGFHGNWAPR
>Mature_502_residues
TATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQ
WYRNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEGGIANYELTEDLDTIGTCDFDGTLPGGYT
AHPHTDPDTGEMHAVSYSFARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVPV
PRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFHP
LNGYSEMRNGAEVIVIDLVRYDSMFSQDVLGPSDAKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGYL
PDVENFFGSGEAAGASIVKYDYETGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSLD
LMATVHLPQRVPAGFHGNWAPR

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4506591, Length=250, Percent_Identity=24.4, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567957, Length=227, Percent_Identity=29.0748898678414, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567955, Length=227, Percent_Identity=29.0748898678414, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 54971; Mature: 54839

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRNGPNPAAEVDPAT
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCCCE
YHLFSGDAMVHGLSLREGKAQWYRNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNV
EEEECCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCCEEEECCCCCE
LGHAGRTLALVEGGIANYELTEDLDTIGTCDFDGTLPGGYTAHPHTDPDTGEMHAVSYSF
ECCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
ARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVP
CCCCEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCEEEEEEECCCEEEHHHHHCCCC
VPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPREGD
HHHHHHHHHHHHHHHHHCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
DASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLVRYDSMFSQDVLGPSDAKGQL
CCCCCCCEEEEEECCEEEEECCCCHHHHCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCCC
DRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGYLPDVENFFGSGEAAGASIVK
EEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEE
YDYETGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSL
EECCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCC
DLMATVHLPQRVPAGFHGNWAPR
EEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRNGPNPAAEVDPAT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCCCE
YHLFSGDAMVHGLSLREGKAQWYRNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNV
EEEECCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCCEEEECCCCCE
LGHAGRTLALVEGGIANYELTEDLDTIGTCDFDGTLPGGYTAHPHTDPDTGEMHAVSYSF
ECCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
ARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVP
CCCCEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCEEEEEEECCCEEEHHHHHCCCC
VPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPREGD
HHHHHHHHHHHHHHHHHCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
DASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLVRYDSMFSQDVLGPSDAKGQL
CCCCCCCEEEEEECCEEEEECCCCHHHHCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCCC
DRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGYLPDVENFFGSGEAAGASIVK
EEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEE
YDYETGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSL
EECCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCC
DLMATVHLPQRVPAGFHGNWAPR
EEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]