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The map label for this gene is lldD1 [H]

Identifier: 169630913

GI number: 169630913

Start: 3880411

End: 3881589

Strand: Reverse

Name: lldD1 [H]

Synonym: MAB_3834c

Alternate gene names: 169630913

Gene position: 3881589-3880411 (Counterclockwise)

Preceding gene: 169630914

Following gene: 169630912

Centisome position: 76.6

GC content: 64.8

Gene sequence:

>1179_bases
ATGGCCCGCAACAAATGGTTCGAGACGGTCGCGATAGCCCAGCAGCGGGCCAAGAAGCGGTTGCCGAAGTCCGTCTACAG
CTCGCTGATCTCGGCCAGTGAAAAGGGCCTGACTGTCAGCGACAATGTCGAGGCGTTCGGCGAGCTCGGGTTCGAGCCGC
ATGTCGTCGGCATCCAGCCGGATCGGGAGCTCTCGACAACCGTTCTAGGGCAAGATATTTCATTGCCGGTCATGATTTCT
CCCACCGGGGTGCAGGCCGTCGATCCTGACGGCGAGGTTGCCGTGGCGAGGGCCGCGGCCGCACGCGGCACGGCTATGGG
TCTGTCCTCGTTCGCGAGCAAGCCCATCGAGGATGTGGTGGCCGCGAACCCCAAGACCCACTTCCAAATCTATTGGCTGG
GTGGCCGCGACGATGTCGCACAGCGCATCCAGCGCGCCAAAGACGCTGGAGCTGTGGGTCTTATCGCCACCCTCGATTGG
AGCTTCTCGCACGGGCGTGACTGGGGCAGTCCCGCCATACCCGAGAAAATGGACCTGCGATCGATGATTCGGTTGGCGCC
CGAAGTCGTCACCAAGCCCAGCTGGCTGTGGTCGTTCGGCAAGGGAATGAACATCCCGGACCTACGGGTGCCCAACCAGG
CGGCCCGCGGCGAGGCCGGCCCACCGTTCTTCGACGCCTATGGGCAGTGGATGGGGACCCCGGCGCCCACCTGGGATGAC
GTGCGCTGGATGCGCGAGCAGTGGGACGGTCCGTTCATGCTCAAGGGCGTGATGCGCATCGATGACGCCAAACGTGCTGT
GGATTGCGGAGTCTCGGCGATTTCGGTGTCGAACCACGGGGGTAACAACCTTGATGGCACCCCCGCGTCCATCCGTGCGT
TGCCCGGCATCGCCGACGCCGTCGGACACGATATCGAGGTGCTGCTGGATGGCGGTATCCGTCGGGGCAGCGATGTTGTC
AAGGCACTGGCCCTGGGCGCCCGCGCGGTGATGATCGGGCGGGCCTACCTGTGGGGTCTGGCGGCCTCCGGGCAGGCGGG
CGTCGAGAACGTTCTGGACATCATGCGCGGCGGCATCGACTCCGCGCTGATGGGGCTCGGAAAGAAGTCTGTGCACGAGC
TATCCCCAGATGATCTTTTGATCCCGGAGGGGTTTGCCCGGGGCCTCGGCAGGCACTAG

Upstream 100 bases:

>100_bases
TGGCCCCGCCACGGGTCCGGTCGCGCTGACGCTGACGCGTCGACCGCCCTCGCGCGCATGCGATGAGAACCCTCTTTCCA
CCCTACGAGCAGGACGGTAG

Downstream 100 bases:

>100_bases
TTCGGCGCACTGCGAATTGAACACGGTGTCCGGCAGAGTGGGTGTGGCGGCAGGGACTGGCGTGAAAATCGGGGCGAAAT
AGCCCCCTTCGCAAAAGCCG

Product: L-lactate dehydrogenase LldD1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MARNKWFETVAIAQQRAKKRLPKSVYSSLISASEKGLTVSDNVEAFGELGFEPHVVGIQPDRELSTTVLGQDISLPVMIS
PTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVVAANPKTHFQIYWLGGRDDVAQRIQRAKDAGAVGLIATLDW
SFSHGRDWGSPAIPEKMDLRSMIRLAPEVVTKPSWLWSFGKGMNIPDLRVPNQAARGEAGPPFFDAYGQWMGTPAPTWDD
VRWMREQWDGPFMLKGVMRIDDAKRAVDCGVSAISVSNHGGNNLDGTPASIRALPGIADAVGHDIEVLLDGGIRRGSDVV
KALALGARAVMIGRAYLWGLAASGQAGVENVLDIMRGGIDSALMGLGKKSVHELSPDDLLIPEGFARGLGRH

Sequences:

>Translated_392_residues
MARNKWFETVAIAQQRAKKRLPKSVYSSLISASEKGLTVSDNVEAFGELGFEPHVVGIQPDRELSTTVLGQDISLPVMIS
PTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVVAANPKTHFQIYWLGGRDDVAQRIQRAKDAGAVGLIATLDW
SFSHGRDWGSPAIPEKMDLRSMIRLAPEVVTKPSWLWSFGKGMNIPDLRVPNQAARGEAGPPFFDAYGQWMGTPAPTWDD
VRWMREQWDGPFMLKGVMRIDDAKRAVDCGVSAISVSNHGGNNLDGTPASIRALPGIADAVGHDIEVLLDGGIRRGSDVV
KALALGARAVMIGRAYLWGLAASGQAGVENVLDIMRGGIDSALMGLGKKSVHELSPDDLLIPEGFARGLGRH
>Mature_391_residues
ARNKWFETVAIAQQRAKKRLPKSVYSSLISASEKGLTVSDNVEAFGELGFEPHVVGIQPDRELSTTVLGQDISLPVMISP
TGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVVAANPKTHFQIYWLGGRDDVAQRIQRAKDAGAVGLIATLDWS
FSHGRDWGSPAIPEKMDLRSMIRLAPEVVTKPSWLWSFGKGMNIPDLRVPNQAARGEAGPPFFDAYGQWMGTPAPTWDDV
RWMREQWDGPFMLKGVMRIDDAKRAVDCGVSAISVSNHGGNNLDGTPASIRALPGIADAVGHDIEVLLDGGIRRGSDVVK
ALALGARAVMIGRAYLWGLAASGQAGVENVLDIMRGGIDSALMGLGKKSVHELSPDDLLIPEGFARGLGRH

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=364, Percent_Identity=35.7142857142857, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI54234014, Length=368, Percent_Identity=35.054347826087, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI7705393, Length=368, Percent_Identity=35.054347826087, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1790033, Length=383, Percent_Identity=35.509138381201, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI193208036, Length=372, Percent_Identity=32.5268817204301, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566217, Length=286, Percent_Identity=27.6223776223776, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323587, Length=388, Percent_Identity=29.1237113402062, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=32.8042328042328, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=32.8042328042328, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=32.8042328042328, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41934; Mature: 41803

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARNKWFETVAIAQQRAKKRLPKSVYSSLISASEKGLTVSDNVEAFGELGFEPHVVGIQP
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCHHHHHHCCCCCEEEECCC
DRELSTTVLGQDISLPVMISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVV
CCCHHHHHHCCCCCCEEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCCHHHHH
AANPKTHFQIYWLGGRDDVAQRIQRAKDAGAVGLIATLDWSFSHGRDWGSPAIPEKMDLR
HCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHH
SMIRLAPEVVTKPSWLWSFGKGMNIPDLRVPNQAARGEAGPPFFDAYGQWMGTPAPTWDD
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCHHH
VRWMREQWDGPFMLKGVMRIDDAKRAVDCGVSAISVSNHGGNNLDGTPASIRALPGIADA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHCCCHHHH
VGHDIEVLLDGGIRRGSDVVKALALGARAVMIGRAYLWGLAASGQAGVENVLDIMRGGID
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHH
SALMGLGKKSVHELSPDDLLIPEGFARGLGRH
HHHHHCCHHHHHHCCCCCEECCCHHHHHCCCC
>Mature Secondary Structure 
ARNKWFETVAIAQQRAKKRLPKSVYSSLISASEKGLTVSDNVEAFGELGFEPHVVGIQP
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCHHHHHHCCCCCEEEECCC
DRELSTTVLGQDISLPVMISPTGVQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVV
CCCHHHHHHCCCCCCEEEECCCCCEEECCCCCEEHHHHHHHCCHHHHHHHHHCCCHHHHH
AANPKTHFQIYWLGGRDDVAQRIQRAKDAGAVGLIATLDWSFSHGRDWGSPAIPEKMDLR
HCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHH
SMIRLAPEVVTKPSWLWSFGKGMNIPDLRVPNQAARGEAGPPFFDAYGQWMGTPAPTWDD
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCHHH
VRWMREQWDGPFMLKGVMRIDDAKRAVDCGVSAISVSNHGGNNLDGTPASIRALPGIADA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHCCCHHHH
VGHDIEVLLDGGIRRGSDVVKALALGARAVMIGRAYLWGLAASGQAGVENVLDIMRGGID
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHH
SALMGLGKKSVHELSPDDLLIPEGFARGLGRH
HHHHHCCHHHHHHCCCCCEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]