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The map label for this gene is kgtP [H]

Identifier: 169630888

GI number: 169630888

Start: 3859631

End: 3860977

Strand: Reverse

Name: kgtP [H]

Synonym: MAB_3808c

Alternate gene names: 169630888

Gene position: 3860977-3859631 (Counterclockwise)

Preceding gene: 169630889

Following gene: 169630887

Centisome position: 76.2

GC content: 62.06

Gene sequence:

>1347_bases
ATGGCTGTTTCTGCTGCTGACACGTCGACTCCGTCGGGACGCGCGCAGACGCGCCGCGCGATTTGGAACACCATCAGGGG
GTCGTCCGGAAACCTGGTCGAGTGGTACGACGTCTACGTCTACACCGTCTTCGCGATGTACTTCGAGAAGCAATTCTTCG
ACGACTCGGATCAGAACTCGACGGTCTACGTGTACGCGATCTTCGCGGTCACCTTCATCACCCGGCCCTTGGGATCGTGG
TTCTTCGGCCGCTTCGCCGACCGGAACGGCCGCCGCGCCGCGCTGACTCTCAGCGTCTCGCTGATGGCGGCCTGCTCGAT
GGTCATTGCGCTGGTGCCCTCGCGCGGCAGCATCGGCATGGCCGCACCGATCGTGTTGATCCTGTGCCGGCTGGTTCAGG
GATTCGCGACGGGCGGGGAGTACGGCACCTCGGCCACCTACATGTCCGAGGCCGCCACCCGCGAGCGTCGTGGGTTCTTC
TCGTCGTTCCAATACGTGACCCTGGTGGGTGGCCACGTGCTCGCCCAATTCACCCTGCTGATCATCCTGACAGTCTTCGA
TACCGCGCAGGTTCACGAATTCGGTTGGCGCATAGCCTTTGCCACGGGAGGCGTGGCCGCGATCGTCGTGTACTGGCTGC
GGCGCACCATGGATGAATCGCTGAGCGAGGAGCAATTGGCCGCCATCAAGGCGGGCGCCGACACCAGCTCGGGATCTATG
CGTGAGCTACTCACCCGGTACCGGAAACCGCTGTTGCTGTGCTTCCTGATCACCATGGGGGGCACTCTCGCCTTCTACAC
CTACAGCGTCAACGCGCCGGCCATCGTGAAGGCCGCCTATAAGGACCAGGCGATGACGGCCACCTGGATCAACTTGGCAG
GGCTGATTTTCCTGATGCTGCTGCAGCCCGTCGGCGGCATCATCAGTGACAAGGTGGGGCGCAAGCCGCTGCTGCTGTTT
TTCGGCTTTGGCGGTGTCGTCTACACCTATGTCCTCATCACCTATCTGCCGCAGGTGCATGCGCCGATCGTGTCCTTTCT
CCTGGTCGCCGTCTCCTATGTGCTCCTGACCGGCTACACCTCGATCAACGCTCTGGTGAAGTCCGAGCTGTTTCCGTCGC
ATGTGCGCGCACTGGGTGTGGGTGTGGGCTATGCGCTGGCCAACTCGGTGTTCGGCGGGACAGCGCCGCTGATCTATCAG
GCGCTCAAGGAGCACGATCAGGTTCCGCTATTCATCGGGTATGTGACGGTGTGCATCGCGATCTCGCTGGTGGTCTACCT
GTTCTTCCTCAAGAACAAGTCGCAGACCTACCTGGACCGCGAGCAGGGCTCGGCCTTCAACCGATAG

Upstream 100 bases:

>100_bases
ACCAGCAGCCGAAGTTCCCGCCGCGGTGACCAGCACCATCCCCGCTCCTGACCCGGCGCGCCACGGTCCACTGCCGGGTC
CGGGTGGTCAGTAATCCTGC

Downstream 100 bases:

>100_bases
CCCGGCATCGAAACTACGGTTTCTGATGCATCGTGCGAGTGGGTGACGCACAATGCGGCGTGTCGGCGGAGTAAAAGAGC
GCCCGGAGGCGCGATTTGGG

Product: dicarboxylic acid transport integral membrane protein KgtP

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAVSAADTSTPSGRAQTRRAIWNTIRGSSGNLVEWYDVYVYTVFAMYFEKQFFDDSDQNSTVYVYAIFAVTFITRPLGSW
FFGRFADRNGRRAALTLSVSLMAACSMVIALVPSRGSIGMAAPIVLILCRLVQGFATGGEYGTSATYMSEAATRERRGFF
SSFQYVTLVGGHVLAQFTLLIILTVFDTAQVHEFGWRIAFATGGVAAIVVYWLRRTMDESLSEEQLAAIKAGADTSSGSM
RELLTRYRKPLLLCFLITMGGTLAFYTYSVNAPAIVKAAYKDQAMTATWINLAGLIFLMLLQPVGGIISDKVGRKPLLLF
FGFGGVVYTYVLITYLPQVHAPIVSFLLVAVSYVLLTGYTSINALVKSELFPSHVRALGVGVGYALANSVFGGTAPLIYQ
ALKEHDQVPLFIGYVTVCIAISLVVYLFFLKNKSQTYLDREQGSAFNR

Sequences:

>Translated_448_residues
MAVSAADTSTPSGRAQTRRAIWNTIRGSSGNLVEWYDVYVYTVFAMYFEKQFFDDSDQNSTVYVYAIFAVTFITRPLGSW
FFGRFADRNGRRAALTLSVSLMAACSMVIALVPSRGSIGMAAPIVLILCRLVQGFATGGEYGTSATYMSEAATRERRGFF
SSFQYVTLVGGHVLAQFTLLIILTVFDTAQVHEFGWRIAFATGGVAAIVVYWLRRTMDESLSEEQLAAIKAGADTSSGSM
RELLTRYRKPLLLCFLITMGGTLAFYTYSVNAPAIVKAAYKDQAMTATWINLAGLIFLMLLQPVGGIISDKVGRKPLLLF
FGFGGVVYTYVLITYLPQVHAPIVSFLLVAVSYVLLTGYTSINALVKSELFPSHVRALGVGVGYALANSVFGGTAPLIYQ
ALKEHDQVPLFIGYVTVCIAISLVVYLFFLKNKSQTYLDREQGSAFNR
>Mature_447_residues
AVSAADTSTPSGRAQTRRAIWNTIRGSSGNLVEWYDVYVYTVFAMYFEKQFFDDSDQNSTVYVYAIFAVTFITRPLGSWF
FGRFADRNGRRAALTLSVSLMAACSMVIALVPSRGSIGMAAPIVLILCRLVQGFATGGEYGTSATYMSEAATRERRGFFS
SFQYVTLVGGHVLAQFTLLIILTVFDTAQVHEFGWRIAFATGGVAAIVVYWLRRTMDESLSEEQLAAIKAGADTSSGSMR
ELLTRYRKPLLLCFLITMGGTLAFYTYSVNAPAIVKAAYKDQAMTATWINLAGLIFLMLLQPVGGIISDKVGRKPLLLFF
GFGGVVYTYVLITYLPQVHAPIVSFLLVAVSYVLLTGYTSINALVKSELFPSHVRALGVGVGYALANSVFGGTAPLIYQA
LKEHDQVPLFIGYVTVCIAISLVVYLFFLKNKSQTYLDREQGSAFNR

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=433, Percent_Identity=40.1847575057737, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1790550, Length=415, Percent_Identity=27.4698795180723, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1788292, Length=399, Percent_Identity=29.5739348370927, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789941, Length=419, Percent_Identity=27.2076372315036, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082404, Length=347, Percent_Identity=23.6311239193084, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082231, Length=188, Percent_Identity=30.8510638297872, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 49150; Mature: 49019

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSAADTSTPSGRAQTRRAIWNTIRGSSGNLVEWYDVYVYTVFAMYFEKQFFDDSDQNS
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVYVYAIFAVTFITRPLGSWFFGRFADRNGRRAALTLSVSLMAACSMVIALVPSRGSIGM
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCH
AAPIVLILCRLVQGFATGGEYGTSATYMSEAATRERRGFFSSFQYVTLVGGHVLAQFTLL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IILTVFDTAQVHEFGWRIAFATGGVAAIVVYWLRRTMDESLSEEQLAAIKAGADTSSGSM
HHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
RELLTRYRKPLLLCFLITMGGTLAFYTYSVNAPAIVKAAYKDQAMTATWINLAGLIFLML
HHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LQPVGGIISDKVGRKPLLLFFGFGGVVYTYVLITYLPQVHAPIVSFLLVAVSYVLLTGYT
HHHHCHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SINALVKSELFPSHVRALGVGVGYALANSVFGGTAPLIYQALKEHDQVPLFIGYVTVCIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ISLVVYLFFLKNKSQTYLDREQGSAFNR
HHHHHHHHHHCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVSAADTSTPSGRAQTRRAIWNTIRGSSGNLVEWYDVYVYTVFAMYFEKQFFDDSDQNS
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVYVYAIFAVTFITRPLGSWFFGRFADRNGRRAALTLSVSLMAACSMVIALVPSRGSIGM
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCH
AAPIVLILCRLVQGFATGGEYGTSATYMSEAATRERRGFFSSFQYVTLVGGHVLAQFTLL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IILTVFDTAQVHEFGWRIAFATGGVAAIVVYWLRRTMDESLSEEQLAAIKAGADTSSGSM
HHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
RELLTRYRKPLLLCFLITMGGTLAFYTYSVNAPAIVKAAYKDQAMTATWINLAGLIFLML
HHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LQPVGGIISDKVGRKPLLLFFGFGGVVYTYVLITYLPQVHAPIVSFLLVAVSYVLLTGYT
HHHHCHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SINALVKSELFPSHVRALGVGVGYALANSVFGGTAPLIYQALKEHDQVPLFIGYVTVCIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ISLVVYLFFLKNKSQTYLDREQGSAFNR
HHHHHHHHHHCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]