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The map label for this gene is guaA [H]

Identifier: 169630797

GI number: 169630797

Start: 3772615

End: 3774195

Strand: Reverse

Name: guaA [H]

Synonym: MAB_3718c

Alternate gene names: 169630797

Gene position: 3774195-3772615 (Counterclockwise)

Preceding gene: 169630798

Following gene: 169630794

Centisome position: 74.48

GC content: 65.65

Gene sequence:

>1581_bases
GTGGCGCAAACGGAGCAGCATGGCGACAGACCGGTTCTGGTCATCGACTTCGGGGCACAGTACGCGCAGCTGATCGCACG
TCGCGTGCGTGAGGCGCGGGTGTTCTCTGAGGTGATCCCGCATTCGGCGAGTGTCGAGGAGATCAAGGGACGCAACCCCC
GGGCGATCGTGCTCTCCGGTGGTCCGTCGAGCGTCTACGAAGAGGGCGCGCCTCAGCTCGATCCCGGCGTATTCGATTTG
GATGTCCCGGTTTTCGGCATCTGCTACGGCTTCCAGGCCATGGCGCAGGTGCTCGGCGGAACCGTCGCGCACACCGGCAC
CAGCGAGTATGGCCGTACCGAGCTAACGGTCGCCGGCGGAGACCTGCATGAAGGCCTGCCCGATGTGCAGCCGGTGTGGA
TGAGCCATGGCGACGCGGTTACCGAGGCACCACAGGGTTTTACCGTCGTCGCCAGCAGCGAGGGCGCCCCGGTGGCGGCG
TTCGAGAATCGGGAACGACGGCTGGCCGGGGTGCAGTACCACCCCGAGGTGCTGCACTCGCCGCATGGACAGCAGGTGCT
GAGCCGCTTTCTGCATGAGTTCGCCGGCATCGAATCGGCATGGACCGCAGCCAATATCGCCGAGACACTCGTCGAGCAGG
TGCGCACGCAGATCGGTGAGGGACGCGCGCTGTGCGCGTTGTCGGGCGGGGTCGATTCCGCGGTGGCGGCGGCTTTGGTG
CAACGTGCCATCGGCGACAGGTTGACCTGTGTATTTGTTGATCACGGTCTGCTGCGCAGTGGTGAGCGGGCTCAGGTCGA
GCATGATTTCGTGGCGGCGACCGGCGCCACGTTGGTGACCGTGGACGCGTCGGAGACATTCCTGGGCGAGCTGGCCGGGG
TCACCGATCCGGAGGCCAAACGCAAAATCATTGGCCGCGAATTCATCCGGTCCTTCGAGGGCGCGGTCTCCGATGTCGTC
GGCGACTCGCGACGCGACGACACTGCGGGTATCCAATTCTTGGTCCAGGGCACGCTGTATCCGGATGTCGTCGAGTCTGG
CGGCGGCAGCGGTACGGCCAACATCAAGAGCCACCACAATGTGGGCGGGTTGCCCGAAGACCTGACCTTCACTCTCGTGG
AGCCGCTGCGGCTGTTGTTCAAGGACGAGGTCCGCGCGGTGGGCCGTGAACTGGGGCTGCCCGAGGAAATCGTCGGCCGT
CAGCCCTTCCCGGGACCAGGCCTGGCCATCAGGATCGTCGGCGAGGTCACGCCCGATCGGCTGGACACCCTGCGCCGCGC
CGATGCCATTGCGCGCGAGGAACTTACCGCTGCGGGACAGGACCGCAATATCTGGCAGTGCCCGGTGGTGTTGTTGGCCG
ATGTGCGCTCGGTCGGAGTACAGGGCGACGGACGCACGTACGGACATCCCATCGTGCTGCGACCGGTGTCCAGCGAGGAC
GCGATGACCGCCGACTGGACTCGGTTGCCCTACGAGGTACTGGAGCGGATTTCGACGCGGATCACCAACGAGGTCCCCGA
GGTGAACCGGGTGGTGCTGGACATCACCAGCAAGCCGCCTGGCACCATCGAATGGGAGTGA

Upstream 100 bases:

>100_bases
GCGCTGCGGCGTCTGCCGATCGAACCGGTGAGCTCGGCCAGTTAGATCCGGGCCAATCCCCCCACGTGGGAGGTGCCCCC
AGCACCACTAAGCTAAGCCG

Downstream 100 bases:

>100_bases
TCCACTAGCTACGGCCGCGCCTGGTCGGAACTGCCACCAGCGCAACGCCGATGGCGATAGCGATGGCGATCGCGAGCCAG
CCCAGCAGGTCGCTGTGTAT

Product: GMP synthase [glutamine-hydrolyzing]

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MAQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDL
DVPVFGICYGFQAMAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEAPQGFTVVASSEGAPVAA
FENRERRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALV
QRAIGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTDPEAKRKIIGREFIRSFEGAVSDVV
GDSRRDDTAGIQFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEEIVGR
QPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRNIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSED
AMTADWTRLPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

Sequences:

>Translated_526_residues
MAQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDL
DVPVFGICYGFQAMAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEAPQGFTVVASSEGAPVAA
FENRERRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALV
QRAIGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTDPEAKRKIIGREFIRSFEGAVSDVV
GDSRRDDTAGIQFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEEIVGR
QPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRNIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSED
AMTADWTRLPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
>Mature_525_residues
AQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLD
VPVFGICYGFQAMAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEAPQGFTVVASSEGAPVAAF
ENRERRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQ
RAIGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTDPEAKRKIIGREFIRSFEGAVSDVVG
DSRRDDTAGIQFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEEIVGRQ
PFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRNIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDA
MTADWTRLPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=558, Percent_Identity=36.2007168458781, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1788854, Length=535, Percent_Identity=48.2242990654206, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789760, Length=152, Percent_Identity=33.5526315789474, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=36.0967184801382, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=36.0967184801382, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=577, Percent_Identity=36.0485268630849, Blast_Score=288, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=46.0500963391137, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322638, Length=159, Percent_Identity=30.8176100628931, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=33.879781420765, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56539; Mature: 56408

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVEEIKGRNPRAIVLSG
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEC
GPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQAMAQVLGGTVAHTGTSEYGRTELTVAGG
CCCHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECC
DLHEGLPDVQPVWMSHGDAVTEAPQGFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHS
HHHCCCCCCCHHHHCCCCHHHCCCCCEEEEECCCCCCEEHHCCCHHHHCCCCCCHHHHCC
PHGQQVLSRFLHEFAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALV
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QRAIGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTDPEAK
HHHHCCCEEEEEECCHHHCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHCCCCCCHHH
RKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDVVESGGGSGTANIKSHHN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEEECCCCHHHHHCCCCCCCCCCCCCCC
VGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEEIVGRQPFPGPGLAIRIVGEVTPDR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEEECCCHHH
LDTLRRADAIAREELTAAGQDRNIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSED
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
AMTADWTRLPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
CCCCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVEEIKGRNPRAIVLSG
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEC
GPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQAMAQVLGGTVAHTGTSEYGRTELTVAGG
CCCHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECC
DLHEGLPDVQPVWMSHGDAVTEAPQGFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHS
HHHCCCCCCCHHHHCCCCHHHCCCCCEEEEECCCCCCEEHHCCCHHHHCCCCCCHHHHCC
PHGQQVLSRFLHEFAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALV
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QRAIGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTDPEAK
HHHHCCCEEEEEECCHHHCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHCCCCCCHHH
RKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDVVESGGGSGTANIKSHHN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEEECCCCHHHHHCCCCCCCCCCCCCCC
VGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEEIVGRQPFPGPGLAIRIVGEVTPDR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEEECCCHHH
LDTLRRADAIAREELTAAGQDRNIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSED
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
AMTADWTRLPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
CCCCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA