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The map label for this gene is fadH [C]

Identifier: 169630773

GI number: 169630773

Start: 3748189

End: 3749367

Strand: Direct

Name: fadH [C]

Synonym: MAB_3694

Alternate gene names: 169630773

Gene position: 3748189-3749367 (Clockwise)

Preceding gene: 169630769

Following gene: 169630774

Centisome position: 73.97

GC content: 64.89

Gene sequence:

>1179_bases
ATGGGCAGTGACGCCGCAGGAATTCCCGACGTGCTGGCGCCCGCGCGGCTCGGTCCGATCACGCTGCGCAACCGGACGAT
CAAGGCCGCGACGTTTGAGGCCGCCTCCCCGGACGCCTTCGTCACCGACGATCTCATCGAGTATCACCGCAGGCCCGCGC
TCGGCGGAGTCGGGATGACGACCGTGGCCTATTGCGCGGTCGCGCCCGAGGGACGTACCGAGTATGGGCAGGTATGGATG
CGCGAAGAGGCCATCCCCGGGCTGCGCCGCCTCACCGATGCCATCCACGACACCGGCGCCGCCGTCTCGGCTCAGATCGG
TCATGCCGGACCGGTGGCCAACGCACGGTCCAACGGATCCCCGGCCCTCTCCCCGATCCGGTTCTTCAATCCGCTGGGCA
TGAAATTCGCACGCCGCGCCAGCGCCTCCGATATCGACGGCGTCATCGCCGCCCACGCGAACGCGGCCCGGCTGGCAATT
GAAGCGGGCTTCGATGCCGTCGAAATCCATTTGGGACACGGATATTTCGTGAGTTCGTTCCTGAGCCCGCTGTTCAACCG
GCGCGGAGATGAGTACGGCGGATCGCTGGCCAACCGCGCCAAGGTAGCCCGCGCGGTGGTTCAAGCAGTACGCAAGGTTG
CCGGCAGCCGCTTGGCCGTCACCGCCAAACTAACCATGACCGACGGCATCCGCGGCGGCATACCCATCGAGGAGTCTCTA
CAAACGGCCACCTGGCTACAGGAGGACGGTGGACTCGATGCCCTGGAATTGACCGCGGGCAGCTCCCTGGTCAATCCCAT
GTACCTGTTCCGTGGCGACGTGCCGATCCGCGAACTCGCCAAGGGCTTCCCCAAACCCATGGGTTGGGGCGTACGCCTGA
CCGGAAAGAAGTTCTTTCGGTCGTACCCCTATCACGACGCGTTCTTGCTCGAGGATGCCCGTCGGTTCCGCGCCGAACTG
GACATACCGTTGATTCTGCTGGGCGGCATCACCGGTGGTGAATCGATGGACCTGGCCATGGCCGAGGGCTTCGAGTTCGT
GGCCATGGGCCGCGCGCTACTCGCCGATCCCGACCTGGTGAATCGGGTGGCGGCCGACCGGGCATCTCATTCGCGGTGTA
CCCACTGCAATCAATGCATGGCAACGATTTTCAGCAAAACGCACTGCGTGCTCACCTAG

Upstream 100 bases:

>100_bases
AGGGAGGTCATATGACGAACGTACATCCACCGGACTTGCCTAAAATTAGGAGTCCACATCCAGAATTCGCCGGCCATGGG
CACGGCGTAATCTGCCGCCC

Downstream 100 bases:

>100_bases
CATCACTGTCATGATGACAGCGGCCGCGGGCCGGAAACCGGGGACTGCGGAGACCGTTGTCAGCTGGCTGTTGTGGGTGC
TGGTGAGCGCGACGGCGGGC

Product: oxidoreductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MGSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHRRPALGGVGMTTVAYCAVAPEGRTEYGQVWM
REEAIPGLRRLTDAIHDTGAAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRASASDIDGVIAAHANAARLAI
EAGFDAVEIHLGHGYFVSSFLSPLFNRRGDEYGGSLANRAKVARAVVQAVRKVAGSRLAVTAKLTMTDGIRGGIPIEESL
QTATWLQEDGGLDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTGKKFFRSYPYHDAFLLEDARRFRAEL
DIPLILLGGITGGESMDLAMAEGFEFVAMGRALLADPDLVNRVAADRASHSRCTHCNQCMATIFSKTHCVLT

Sequences:

>Translated_392_residues
MGSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHRRPALGGVGMTTVAYCAVAPEGRTEYGQVWM
REEAIPGLRRLTDAIHDTGAAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRASASDIDGVIAAHANAARLAI
EAGFDAVEIHLGHGYFVSSFLSPLFNRRGDEYGGSLANRAKVARAVVQAVRKVAGSRLAVTAKLTMTDGIRGGIPIEESL
QTATWLQEDGGLDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTGKKFFRSYPYHDAFLLEDARRFRAEL
DIPLILLGGITGGESMDLAMAEGFEFVAMGRALLADPDLVNRVAADRASHSRCTHCNQCMATIFSKTHCVLT
>Mature_391_residues
GSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHRRPALGGVGMTTVAYCAVAPEGRTEYGQVWMR
EEAIPGLRRLTDAIHDTGAAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRASASDIDGVIAAHANAARLAIE
AGFDAVEIHLGHGYFVSSFLSPLFNRRGDEYGGSLANRAKVARAVVQAVRKVAGSRLAVTAKLTMTDGIRGGIPIEESLQ
TATWLQEDGGLDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTGKKFFRSYPYHDAFLLEDARRFRAELD
IPLILLGGITGGESMDLAMAEGFEFVAMGRALLADPDLVNRVAADRASHSRCTHCNQCMATIFSKTHCVLT

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=393, Percent_Identity=26.2086513994911, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1787939, Length=372, Percent_Identity=25.2688172043011, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17566914, Length=230, Percent_Identity=32.1739130434783, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=386, Percent_Identity=26.1658031088083, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17564188, Length=386, Percent_Identity=25.6476683937824, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540738, Length=366, Percent_Identity=25.6830601092896, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559802, Length=369, Percent_Identity=24.6612466124661, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001454, Length=377, Percent_Identity=24.6684350132626, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565138, Length=369, Percent_Identity=23.8482384823848, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=75, Percent_Identity=42.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321973, Length=225, Percent_Identity=27.5555555555556, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 41923; Mature: 41792

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHRRPALGGVGMT
CCCCCCCCCHHHCCCCCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHH
TVAYCAVAPEGRTEYGQVWMREEAIPGLRRLTDAIHDTGAAVSAQIGHAGPVANARSNGS
HHHHHEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
PALSPIRFFNPLGMKFARRASASDIDGVIAAHANAARLAIEAGFDAVEIHLGHGYFVSSF
CCCCHHHHHCHHHHHHHHHCCCCCCCCHHCCCCCHHEEEEECCCCEEEEEECCCHHHHHH
LSPLFNRRGDEYGGSLANRAKVARAVVQAVRKVAGSRLAVTAKLTMTDGIRGGIPIEESL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHH
QTATWLQEDGGLDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTGKKFFR
HHHHHHHHCCCCCEEEECCCCCHHCCHHEEECCCCHHHHHHHCCCCCCCCEEECCHHHHH
SYPYHDAFLLEDARRFRAELDIPLILLGGITGGESMDLAMAEGFEFVAMGRALLADPDLV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCHHHHHCHHHHCCHHHH
NRVAADRASHSRCTHCNQCMATIFSKTHCVLT
HHHHHHHCCCHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure 
GSDAAGIPDVLAPARLGPITLRNRTIKAATFEAASPDAFVTDDLIEYHRRPALGGVGMT
CCCCCCCCHHHCCCCCCCEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHH
TVAYCAVAPEGRTEYGQVWMREEAIPGLRRLTDAIHDTGAAVSAQIGHAGPVANARSNGS
HHHHHEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
PALSPIRFFNPLGMKFARRASASDIDGVIAAHANAARLAIEAGFDAVEIHLGHGYFVSSF
CCCCHHHHHCHHHHHHHHHCCCCCCCCHHCCCCCHHEEEEECCCCEEEEEECCCHHHHHH
LSPLFNRRGDEYGGSLANRAKVARAVVQAVRKVAGSRLAVTAKLTMTDGIRGGIPIEESL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHH
QTATWLQEDGGLDALELTAGSSLVNPMYLFRGDVPIRELAKGFPKPMGWGVRLTGKKFFR
HHHHHHHHCCCCCEEEECCCCCHHCCHHEEECCCCHHHHHHHCCCCCCCCEEECCHHHHH
SYPYHDAFLLEDARRFRAELDIPLILLGGITGGESMDLAMAEGFEFVAMGRALLADPDLV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHCCCHHHHHCHHHHCCHHHH
NRVAADRASHSRCTHCNQCMATIFSKTHCVLT
HHHHHHHCCCHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]