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The map label for this gene is icd [H]

Identifier: 169630765

GI number: 169630765

Start: 3739460

End: 3741697

Strand: Reverse

Name: icd [H]

Synonym: MAB_3686c

Alternate gene names: 169630765

Gene position: 3741697-3739460 (Counterclockwise)

Preceding gene: 169630770

Following gene: 169630763

Centisome position: 73.84

GC content: 62.87

Gene sequence:

>2238_bases
ATGAGTGCGCAGCAGCCGACCATCATCTACACGCTGACAGACGAGGCGCCGCTGCTCGCGACGTACTCCTTCTTGCCGAT
CATCCGGGCATTCGCCGGGCCGGCGGGTATCGACGTCCAAACCAGTGACATCTCCGTTGCCGCACGCATCCTCTCCGAGT
TCTCCGAGTACCTTCCCGAAGACCAGCGTGTTCCGGACAACCTGGCCGAGCTGGGCCGCCTGACACAGCTTCCGGAAACC
AACATCATCAAGCTGCCGAATATCAGTGCGTCGGTGCCGCAGCTGCTGGCCGCGATCAAGGAACTACAGGGCAAGGGCTA
CAAGCTGCCCGAGTACCCGGGGGACCCCAAGAACGAAGAAGAAACTGAGATCAAGGCGCGGTACACCAAGTGTCTCGGTA
GTGCGGTGAATCCCATTCTGCGTGAAGGCAACTCGGACCGTCGCGCCCCGAAGGCGGTGAAGGAGTACGCCCGCAAGCAC
CCGCACAGCATGGGCGAGTGGTCGCAGGCCTCGCGCACGCATGTCGCCACCATGAAGGAGGGCGATTTCTACCACGGAGA
GAAGTCGCTGACGCTGGATCGCGACCGCACGGTGAAGATGGTGCTGACCACCAAGAGCGGTGACACCGTCGTGCTCAAGC
CCGAGGTCAAGCTGGGCAAGGGCGACATCATCGACAGCATGTTCATGAGTAAGAAGGCGCTCTGCGACTTCTACGAGGAG
CAGATCGAAGACGCCTACAAGACCGGTGTGATGCTGTCCTTGCACGTCAAGGCGACCATGATGCGGGTCAGCCACCCCAT
CGTCTTCGGCCACGCGGTCAAGATCTTCTACAAGGACGCCTTCGAAAAGCACCAGAAGCTGTTCGACGAGCTGGGCGTCA
ACGTCAACAATGGATTGTCGGACCTGTACAGCAAGATCGAGGCCCTGCCCGCGTCGCAGCACGAGGAGATCATCCGCGAC
CTGCACGCCTGTCACGAGCACCGGCCGGAGCTGGCCATGGTGGACTCGGCCAAGGGTATTTCGAACTTCCACTCGCCCAG
CGACGTGATCGTCGACGCCTCGATGCCGGCCATGATTCGGGCCGGCGGCAAGATGTACGGCGCCGACGGCAAGCTCAAGG
ACACCAAGGCCGTCAACCCCGAGTCGACCTTCTCCCGGATCTACCAGGAGATGATCAACTTCGTGAAGACCCACGGCCAG
TTCGACCCGAGGACCATGGGCACCGTTCCCAACGTCGGTCTGATGGCGCAGAAGGCCGAGGAGTACGGCAGCCACGACAA
GACCTTCGAGATCGCCGAGGCCGGTGTCGCCGACATCGTCGACATCGACACCGGCGAGGTACTGCTGACACAGAACGTTG
AAGAGGGCGATATCTGGCGCATGCCGGTCGTCACCGATGCCGCTATTCAGGACTGGGTCAAGCTCGCCGTCACGCGGGGG
CGCGAGTCGGGGATGAACGTGGTGTTCTGGCTGGACACCGAGCGTCCGCACGAGGTGGAACTGCGTAAGAAGGTCAAGGA
ATACCTGCAGGATCACGACACCGAGGGCCTCAAGATTCAGGTTGTGCCTCAGGTGTGGGCCATGCGGTACACCCTGGAGC
GACTGATCCGCGGTAAGGACACCATCGCCGCGACCGGCAACATCCTGCGCGACTACCTCACCGACCTGTTCCCGATCCTG
GAGCTGGGTACCAGTGCCAAGATGCTCTCCATCGTGCCGTTGATGGCCGGAGGCGGACTGTACGAGACGGGCGCCGGGGG
GTCGGCGCCCAAGCACGTGAGCCAGCTGGTCGAGGAGAACCATCTGCGGTGGGATTCGCTCGGTGAGTTCCTGGCACTGG
CCGTCAGCCTCGAAGACTTGGGCATCAAGACCGGGAACGCCCGGGCCAAGATTCTGGCCACCACGCTGGATGCCGCGACC
GGAAAGCTGCTGGAGAACGACAAGAGTCCGTCCCGCAAGGCCGGCGAGCTCGACAACCGTGGCAGCCAGTTCTATCTGGC
GTTGTACTGGGCGGCCGAGCTGGCCGCGCAGACCGAAGACGTGGAACTGGCCGAGCTGTTCGCACCGCTGGCCAAGCAGC
TGGTCGAGAACGAGGATCAGATTGTGGCCGAGCTTGCCGCCGTGCAGGGCAGCCCGGCCGATATCGGTGGCTACTACGCA
CCGGACCCCGAGAAGACCAACGCCGTCATGCGGCCGAGCCAGACGTTCAACGCCGCCCTGGCGTCCGTCGAGGTCTAG

Upstream 100 bases:

>100_bases
CGAAGGCGACGTGATACTGAATAGGGCATCCGTGTGACCCACGGGGTACCTGAGATTTTGACCGACCAACAAGTCCGATC
AACGATGCCGGGAGTGACTA

Downstream 100 bases:

>100_bases
AACCAACGCCGACACGCCGCGTTCTGACGCGTTTCCCGAGAGGGGCGCGCAGAACGCGGCGTGTCGGCGTTTACGTGTTG
CTATCCGGCGTCGGACGCGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MSAQQPTIIYTLTDEAPLLATYSFLPIIRAFAGPAGIDVQTSDISVAARILSEFSEYLPEDQRVPDNLAELGRLTQLPET
NIIKLPNISASVPQLLAAIKELQGKGYKLPEYPGDPKNEEETEIKARYTKCLGSAVNPILREGNSDRRAPKAVKEYARKH
PHSMGEWSQASRTHVATMKEGDFYHGEKSLTLDRDRTVKMVLTTKSGDTVVLKPEVKLGKGDIIDSMFMSKKALCDFYEE
QIEDAYKTGVMLSLHVKATMMRVSHPIVFGHAVKIFYKDAFEKHQKLFDELGVNVNNGLSDLYSKIEALPASQHEEIIRD
LHACHEHRPELAMVDSAKGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEMINFVKTHGQ
FDPRTMGTVPNVGLMAQKAEEYGSHDKTFEIAEAGVADIVDIDTGEVLLTQNVEEGDIWRMPVVTDAAIQDWVKLAVTRG
RESGMNVVFWLDTERPHEVELRKKVKEYLQDHDTEGLKIQVVPQVWAMRYTLERLIRGKDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVSQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNARAKILATTLDAAT
GKLLENDKSPSRKAGELDNRGSQFYLALYWAAELAAQTEDVELAELFAPLAKQLVENEDQIVAELAAVQGSPADIGGYYA
PDPEKTNAVMRPSQTFNAALASVEV

Sequences:

>Translated_745_residues
MSAQQPTIIYTLTDEAPLLATYSFLPIIRAFAGPAGIDVQTSDISVAARILSEFSEYLPEDQRVPDNLAELGRLTQLPET
NIIKLPNISASVPQLLAAIKELQGKGYKLPEYPGDPKNEEETEIKARYTKCLGSAVNPILREGNSDRRAPKAVKEYARKH
PHSMGEWSQASRTHVATMKEGDFYHGEKSLTLDRDRTVKMVLTTKSGDTVVLKPEVKLGKGDIIDSMFMSKKALCDFYEE
QIEDAYKTGVMLSLHVKATMMRVSHPIVFGHAVKIFYKDAFEKHQKLFDELGVNVNNGLSDLYSKIEALPASQHEEIIRD
LHACHEHRPELAMVDSAKGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEMINFVKTHGQ
FDPRTMGTVPNVGLMAQKAEEYGSHDKTFEIAEAGVADIVDIDTGEVLLTQNVEEGDIWRMPVVTDAAIQDWVKLAVTRG
RESGMNVVFWLDTERPHEVELRKKVKEYLQDHDTEGLKIQVVPQVWAMRYTLERLIRGKDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVSQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNARAKILATTLDAAT
GKLLENDKSPSRKAGELDNRGSQFYLALYWAAELAAQTEDVELAELFAPLAKQLVENEDQIVAELAAVQGSPADIGGYYA
PDPEKTNAVMRPSQTFNAALASVEV
>Mature_744_residues
SAQQPTIIYTLTDEAPLLATYSFLPIIRAFAGPAGIDVQTSDISVAARILSEFSEYLPEDQRVPDNLAELGRLTQLPETN
IIKLPNISASVPQLLAAIKELQGKGYKLPEYPGDPKNEEETEIKARYTKCLGSAVNPILREGNSDRRAPKAVKEYARKHP
HSMGEWSQASRTHVATMKEGDFYHGEKSLTLDRDRTVKMVLTTKSGDTVVLKPEVKLGKGDIIDSMFMSKKALCDFYEEQ
IEDAYKTGVMLSLHVKATMMRVSHPIVFGHAVKIFYKDAFEKHQKLFDELGVNVNNGLSDLYSKIEALPASQHEEIIRDL
HACHEHRPELAMVDSAKGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEMINFVKTHGQF
DPRTMGTVPNVGLMAQKAEEYGSHDKTFEIAEAGVADIVDIDTGEVLLTQNVEEGDIWRMPVVTDAAIQDWVKLAVTRGR
ESGMNVVFWLDTERPHEVELRKKVKEYLQDHDTEGLKIQVVPQVWAMRYTLERLIRGKDTIAATGNILRDYLTDLFPILE
LGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVSQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNARAKILATTLDAATG
KLLENDKSPSRKAGELDNRGSQFYLALYWAAELAAQTEDVELAELFAPLAKQLVENEDQIVAELAAVQGSPADIGGYYAP
DPEKTNAVMRPSQTFNAALASVEV

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82186; Mature: 82055

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQQPTIIYTLTDEAPLLATYSFLPIIRAFAGPAGIDVQTSDISVAARILSEFSEYLPE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCC
DQRVPDNLAELGRLTQLPETNIIKLPNISASVPQLLAAIKELQGKGYKLPEYPGDPKNEE
CCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
ETEIKARYTKCLGSAVNPILREGNSDRRAPKAVKEYARKHPHSMGEWSQASRTHVATMKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEEEC
GDFYHGEKSLTLDRDRTVKMVLTTKSGDTVVLKPEVKLGKGDIIDSMFMSKKALCDFYEE
CCCCCCCCCEEECCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
QIEDAYKTGVMLSLHVKATMMRVSHPIVFGHAVKIFYKDAFEKHQKLFDELGVNVNNGLS
HHHHHHHCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIEALPASQHEEIIRDLHACHEHRPELAMVDSAKGISNFHSPSDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKLKDTKAVNPESTFSRIYQEMINFVKTHGQFDPRTMGTVPNVGLMAQKAE
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIAEAGVADIVDIDTGEVLLTQNVEEGDIWRMPVVTDAAIQDWVKLAVTRG
HHCCCCCEEHHHHCCCHHEEECCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHCC
RESGMNVVFWLDTERPHEVELRKKVKEYLQDHDTEGLKIQVVPQVWAMRYTLERLIRGKD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCC
TIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVSQLVEEN
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEDLGIKTGNARAKILATTLDAATGKLLENDKSPSRKAGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
GSQFYLALYWAAELAAQTEDVELAELFAPLAKQLVENEDQIVAELAAVQGSPADIGGYYA
CCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
PDPEKTNAVMRPSQTFNAALASVEV
CCCCCCCCEECCCHHHHHHHHHCCC
>Mature Secondary Structure 
SAQQPTIIYTLTDEAPLLATYSFLPIIRAFAGPAGIDVQTSDISVAARILSEFSEYLPE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCC
DQRVPDNLAELGRLTQLPETNIIKLPNISASVPQLLAAIKELQGKGYKLPEYPGDPKNEE
CCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
ETEIKARYTKCLGSAVNPILREGNSDRRAPKAVKEYARKHPHSMGEWSQASRTHVATMKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEEEC
GDFYHGEKSLTLDRDRTVKMVLTTKSGDTVVLKPEVKLGKGDIIDSMFMSKKALCDFYEE
CCCCCCCCCEEECCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
QIEDAYKTGVMLSLHVKATMMRVSHPIVFGHAVKIFYKDAFEKHQKLFDELGVNVNNGLS
HHHHHHHCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIEALPASQHEEIIRDLHACHEHRPELAMVDSAKGISNFHSPSDVIVDASMPAMIR
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMYGADGKLKDTKAVNPESTFSRIYQEMINFVKTHGQFDPRTMGTVPNVGLMAQKAE
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIAEAGVADIVDIDTGEVLLTQNVEEGDIWRMPVVTDAAIQDWVKLAVTRG
HHCCCCCEEHHHHCCCHHEEECCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHCC
RESGMNVVFWLDTERPHEVELRKKVKEYLQDHDTEGLKIQVVPQVWAMRYTLERLIRGKD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCC
TIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVSQLVEEN
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEDLGIKTGNARAKILATTLDAATGKLLENDKSPSRKAGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
GSQFYLALYWAAELAAQTEDVELAELFAPLAKQLVENEDQIVAELAAVQGSPADIGGYYA
CCEEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCC
PDPEKTNAVMRPSQTFNAALASVEV
CCCCCCCCEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]