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The map label for this gene is exoA [H]

Identifier: 169630763

GI number: 169630763

Start: 3737526

End: 3738347

Strand: Reverse

Name: exoA [H]

Synonym: MAB_3684c

Alternate gene names: 169630763

Gene position: 3738347-3737526 (Counterclockwise)

Preceding gene: 169630765

Following gene: 169630762

Centisome position: 73.78

GC content: 67.76

Gene sequence:

>822_bases
ATGAGCGCCCAGAAGATCACCGTCACCACCATCAACGTCAATGGCATTCGTGCGGCCGTCAAGGAGCGGTCCGCGGAGAA
TCGGGGACTGCTGCCCTGGCTGGAGCAGACGAGCTCCGACATCGTGTGTCTGCAGGAGGTGCGCGCCGAGGAGGACCAGT
TGCGGGAGGCGCTGGCCCCAGCCCTGGCCGCCGGGTGGCAGGTGGTGAGTGCCGCCTCCAGCGTGAAGGGACGCAGCGGC
GTAGGGATTCTGAGCCGCGTTCCGGCGGCCTCCACCCGGGTGGCCCTGGACGCCGACGGTGGCGAATTCGATGAGTCGGG
CCGGTACCTGGAGGCCGAGATCGGCGACCTGACCGTCGCGAGCATCTATCTGCCCACCGGTGAGGCGGGCACCGCTCGTC
AGGAGGAGAAGGAGCGCTTCATGGCCGCCGTGGGCGCGCGGATGGCCGTCCTGGCCGCCAGTGGGCGGGATACGGTGATC
TGCGGCGATTGGAACATCGGCCATACCGAACGAGATATCAAGGCGTGGAAGGCAAATCAGAAGAAGGCCGGCTTCCTGCC
GGAGGAGCGGGCATGGGTGGGCTCGTTGCTCGAGGCCGGCTGGGTAGACAGTTTCCGGCTACTGCATCCGGATGTGGACG
GGCCGTACAGCTGGTGGTCGTGGCGCGGCAAGGCCTTCGACAACGATGCCGGGTGGCGCATCGACTATCACCTGGCCACG
GCCGATCTTGGGCGACGGGCACATTCGGCGAGGGTCGAGCGGGCCGATGCCTACGCGCTGCGCTGGTCCGATCACGCCCC
GGTGACGGTGGAGTACCGGTAG

Upstream 100 bases:

>100_bases
ATTTACCGTGCCCCGTCTTCTTCGCCTACTCCGCAGTGCTGGTTGTTCTTCGCCCCAGCGGCTCATCACTGTCAGGGCGC
TCGACTATCGTCGGCGACCG

Downstream 100 bases:

>100_bases
GGCGCCTTGCGGCCAGAGCGGCAGCCAGAATCGCTTTGACCGGGCATGCCAGGATGGATGCACTATGACTGCCGAAACCG
CCGCCCGGGGACGCCTGTTC

Product: putative exodeoxyribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSAQKITVTTINVNGIRAAVKERSAENRGLLPWLEQTSSDIVCLQEVRAEEDQLREALAPALAAGWQVVSAASSVKGRSG
VGILSRVPAASTRVALDADGGEFDESGRYLEAEIGDLTVASIYLPTGEAGTARQEEKERFMAAVGARMAVLAASGRDTVI
CGDWNIGHTERDIKAWKANQKKAGFLPEERAWVGSLLEAGWVDSFRLLHPDVDGPYSWWSWRGKAFDNDAGWRIDYHLAT
ADLGRRAHSARVERADAYALRWSDHAPVTVEYR

Sequences:

>Translated_273_residues
MSAQKITVTTINVNGIRAAVKERSAENRGLLPWLEQTSSDIVCLQEVRAEEDQLREALAPALAAGWQVVSAASSVKGRSG
VGILSRVPAASTRVALDADGGEFDESGRYLEAEIGDLTVASIYLPTGEAGTARQEEKERFMAAVGARMAVLAASGRDTVI
CGDWNIGHTERDIKAWKANQKKAGFLPEERAWVGSLLEAGWVDSFRLLHPDVDGPYSWWSWRGKAFDNDAGWRIDYHLAT
ADLGRRAHSARVERADAYALRWSDHAPVTVEYR
>Mature_272_residues
SAQKITVTTINVNGIRAAVKERSAENRGLLPWLEQTSSDIVCLQEVRAEEDQLREALAPALAAGWQVVSAASSVKGRSGV
GILSRVPAASTRVALDADGGEFDESGRYLEAEIGDLTVASIYLPTGEAGTARQEEKERFMAAVGARMAVLAASGRDTVIC
GDWNIGHTERDIKAWKANQKKAGFLPEERAWVGSLLEAGWVDSFRLLHPDVDGPYSWWSWRGKAFDNDAGWRIDYHLATA
DLGRRAHSARVERADAYALRWSDHAPVTVEYR

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=266, Percent_Identity=33.8345864661654, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI18375503, Length=266, Percent_Identity=33.8345864661654, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI18375501, Length=266, Percent_Identity=33.8345864661654, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1788046, Length=284, Percent_Identity=29.9295774647887, Blast_Score=110, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71989536, Length=264, Percent_Identity=29.5454545454545, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221330655, Length=267, Percent_Identity=31.4606741573034, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136678, Length=267, Percent_Identity=31.4606741573034, Blast_Score=120, Evalue=7e-28,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29908; Mature: 29776

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQKITVTTINVNGIRAAVKERSAENRGLLPWLEQTSSDIVCLQEVRAEEDQLREALAP
CCCCEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHCCCCCEEEHHHHHCCHHHHHHHHHH
ALAAGWQVVSAASSVKGRSGVGILSRVPAASTRVALDADGGEFDESGRYLEAEIGDLTVA
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEE
SIYLPTGEAGTARQEEKERFMAAVGARMAVLAASGRDTVICGDWNIGHTERDIKAWKANQ
EEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHHHCCCC
KKAGFLPEERAWVGSLLEAGWVDSFRLLHPDVDGPYSWWSWRGKAFDNDAGWRIDYHLAT
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHCCCCCCCCCCCCCEEEEEEEC
ADLGRRAHSARVERADAYALRWSDHAPVTVEYR
HHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure 
SAQKITVTTINVNGIRAAVKERSAENRGLLPWLEQTSSDIVCLQEVRAEEDQLREALAP
CCCEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHCCCCCEEEHHHHHCCHHHHHHHHHH
ALAAGWQVVSAASSVKGRSGVGILSRVPAASTRVALDADGGEFDESGRYLEAEIGDLTVA
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEE
SIYLPTGEAGTARQEEKERFMAAVGARMAVLAASGRDTVICGDWNIGHTERDIKAWKANQ
EEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHHHCCCC
KKAGFLPEERAWVGSLLEAGWVDSFRLLHPDVDGPYSWWSWRGKAFDNDAGWRIDYHLAT
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHCCCCCCCCCCCCCEEEEEEEC
ADLGRRAHSARVERADAYALRWSDHAPVTVEYR
HHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]