Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 169630584

GI number: 169630584

Start: 3545188

End: 3546612

Strand: Direct

Name: ubiB [C]

Synonym: MAB_3503

Alternate gene names: 169630584

Gene position: 3545188-3546612 (Clockwise)

Preceding gene: 169630583

Following gene: 169630585

Centisome position: 69.96

GC content: 62.6

Gene sequence:

>1425_bases
GTGGCGCTTACTTTGCCGGAAATTGACGAAGCACCACTTTTTGTTAACTTCATCACGAGCGGGCATGATGTGCGCATGGC
AGAGATTCGTCGTGGCCGCGCCGCGCGCGCCGCAAAACTCGCATCGCTTCCGGCCGGTATTGCCGGTCGCGCCGCACTCG
GTGTCGGGAAACGCCTGGCCGGGAAGTCCAAGGACGAAGTCAACGCCGAACTCGTGGAGAAAGCCGCCGAACAGCTCTTC
CAGGTACTCGGCGAACTCAAGGGCGCGGCCATGAAGATTGGCCAAATGCTCTCGGTGATGGAAGCAGCCATCCCACCCGA
ATTCGGCGAGCCCTACCGCGAGGCCCTGACCAAGCTGCAAAGCGACGCCCCACCGCTGCCCGCGGACAAGGTCCACCGCG
TCCTGGATGCCCAGTTGGGCACGAAGTGGCGTGAACGCTTCCAATCCTTCGACGACAAGCCCGTCGCCTCGGCCAGCATC
GGCCAGGTACACAAGGCCGTCTGGAAAGACGGACGCGTTGTCGCCGTCAAGGTGCAATACCCGGGCGCCGACGAGGCCGT
CCGTTCGGACCTCAAGACCATTCAGCGCCTCTCGTCATTGTTCAAGCAGGTGGCACCCGGTGCCGATATCAAGGGCATCG
TTGACGAGCTCATCGAACGCACCGAGGAAGAACTCGACTACCGCATCGAAGCCACCAACCAACGAGCCTTCGCCAAGGCC
TTCAAAGGCGATCCCGAGTTCTACGTGCCCTCGGTAATCGCGTCCTCACCGAAGGTGATCATCACCGAGTGGTTGCAGGG
CCGGAAGCTCTCGGAGATCATCGCCAGCGGTACCGAGGAAGAGCGCAGCAGATGCGCCCACCTGCTGCTGGAGTTCAGCA
TCAGCTCCCCGTACCGCTGCGGACTGCTGCACGCCGACACCCACCCCGGCAATTTCATGCTGTTGGAGGACGGCCGGTTC
GGTGTCATGGACTTCGGCGCCTGCGCATCGCATGAGGGTGGGTTGCCCGCGGGCTTCGGGCCGATCCTGCGTCTGGCCCG
CGACGAGAAATGGGAAGAGCTGACCGAGGTCCTCCGTTCGGAGGGCTTCATCCCGCCCAGCGCCACCTCGGTATCCCATG
AGGAGGTCAACTCCTACCTCGAGCCGTACATCGAGCCGCTCAACTACGACACCTTCCACTTCAGCCGCAAGTGGTTACAA
CGGCTCACCGCCAAGGCCACCGATTTCCGCAGTGAAGAGTTCCTGGAGTCGTTCAAGACCAGCCGGCAGATGAATCTGCC
GCCGAACTATCTGATGTTCTTCCGGGTCCTCGGCGGCCTGATCGGTATCGCCGCACAGCTCGATGCCCCCGTGGACTACG
CGGCCATCATCGACAAATGGGTTCCCGGCTTCCACGAGGACAGCAAGGCCCCAGCCGCCACCTAG

Upstream 100 bases:

>100_bases
CCGCCCGGCCCACTCGCGACGCTCAACGCGACGCTCGAACTCGATCTGGCCACCCACGCGCTGACCGCCCGGCATTGGAC
CGCCCATCCCCTATGCCCCT

Downstream 100 bases:

>100_bases
CCCAAGAGGAAAACCTGCGTTGTCAGAATCATCCGGGCCCCGGCATGATGTAACTCATGGCTGAGATTCGTCGTGGCCGC
GCCGCGCGCGCCGCAAAACT

Product: ABC transporter ATP-binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MALTLPEIDEAPLFVNFITSGHDVRMAEIRRGRAARAAKLASLPAGIAGRAALGVGKRLAGKSKDEVNAELVEKAAEQLF
QVLGELKGAAMKIGQMLSVMEAAIPPEFGEPYREALTKLQSDAPPLPADKVHRVLDAQLGTKWRERFQSFDDKPVASASI
GQVHKAVWKDGRVVAVKVQYPGADEAVRSDLKTIQRLSSLFKQVAPGADIKGIVDELIERTEEELDYRIEATNQRAFAKA
FKGDPEFYVPSVIASSPKVIITEWLQGRKLSEIIASGTEEERSRCAHLLLEFSISSPYRCGLLHADTHPGNFMLLEDGRF
GVMDFGACASHEGGLPAGFGPILRLARDEKWEELTEVLRSEGFIPPSATSVSHEEVNSYLEPYIEPLNYDTFHFSRKWLQ
RLTAKATDFRSEEFLESFKTSRQMNLPPNYLMFFRVLGGLIGIAAQLDAPVDYAAIIDKWVPGFHEDSKAPAAT

Sequences:

>Translated_474_residues
MALTLPEIDEAPLFVNFITSGHDVRMAEIRRGRAARAAKLASLPAGIAGRAALGVGKRLAGKSKDEVNAELVEKAAEQLF
QVLGELKGAAMKIGQMLSVMEAAIPPEFGEPYREALTKLQSDAPPLPADKVHRVLDAQLGTKWRERFQSFDDKPVASASI
GQVHKAVWKDGRVVAVKVQYPGADEAVRSDLKTIQRLSSLFKQVAPGADIKGIVDELIERTEEELDYRIEATNQRAFAKA
FKGDPEFYVPSVIASSPKVIITEWLQGRKLSEIIASGTEEERSRCAHLLLEFSISSPYRCGLLHADTHPGNFMLLEDGRF
GVMDFGACASHEGGLPAGFGPILRLARDEKWEELTEVLRSEGFIPPSATSVSHEEVNSYLEPYIEPLNYDTFHFSRKWLQ
RLTAKATDFRSEEFLESFKTSRQMNLPPNYLMFFRVLGGLIGIAAQLDAPVDYAAIIDKWVPGFHEDSKAPAAT
>Mature_473_residues
ALTLPEIDEAPLFVNFITSGHDVRMAEIRRGRAARAAKLASLPAGIAGRAALGVGKRLAGKSKDEVNAELVEKAAEQLFQ
VLGELKGAAMKIGQMLSVMEAAIPPEFGEPYREALTKLQSDAPPLPADKVHRVLDAQLGTKWRERFQSFDDKPVASASIG
QVHKAVWKDGRVVAVKVQYPGADEAVRSDLKTIQRLSSLFKQVAPGADIKGIVDELIERTEEELDYRIEATNQRAFAKAF
KGDPEFYVPSVIASSPKVIITEWLQGRKLSEIIASGTEEERSRCAHLLLEFSISSPYRCGLLHADTHPGNFMLLEDGRFG
VMDFGACASHEGGLPAGFGPILRLARDEKWEELTEVLRSEGFIPPSATSVSHEEVNSYLEPYIEPLNYDTFHFSRKWLQR
LTAKATDFRSEEFLESFKTSRQMNLPPNYLMFFRVLGGLIGIAAQLDAPVDYAAIIDKWVPGFHEDSKAPAAT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=335, Percent_Identity=29.2537313432836, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI27363457, Length=261, Percent_Identity=29.1187739463602, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI40254938, Length=245, Percent_Identity=29.3877551020408, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI217416386, Length=213, Percent_Identity=27.6995305164319, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217035081, Length=181, Percent_Identity=31.4917127071823, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI41393593, Length=252, Percent_Identity=28.1746031746032, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI2367309, Length=403, Percent_Identity=26.302729528536, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32565180, Length=464, Percent_Identity=28.2327586206897, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=294, Percent_Identity=29.2517006802721, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321319, Length=310, Percent_Identity=27.4193548387097, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=320, Percent_Identity=26.25, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859849, Length=423, Percent_Identity=26.241134751773, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI22024280, Length=243, Percent_Identity=31.6872427983539, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=29.4871794871795, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 52338; Mature: 52207

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTLPEIDEAPLFVNFITSGHDVRMAEIRRGRAARAAKLASLPAGIAGRAALGVGKRLA
CCCCCCCCCCCCEEEEEECCCCCEEHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GKSKDEVNAELVEKAAEQLFQVLGELKGAAMKIGQMLSVMEAAIPPEFGEPYREALTKLQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SDAPPLPADKVHRVLDAQLGTKWRERFQSFDDKPVASASIGQVHKAVWKDGRVVAVKVQY
CCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
PGADEAVRSDLKTIQRLSSLFKQVAPGADIKGIVDELIERTEEELDYRIEATNQRAFAKA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCEEEECCCHHHHHHH
FKGDPEFYVPSVIASSPKVIITEWLQGRKLSEIIASGTEEERSRCAHLLLEFSISSPYRC
HCCCCCEECCHHHHCCCCEEHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
GLLHADTHPGNFMLLEDGRFGVMDFGACASHEGGLPAGFGPILRLARDEKWEELTEVLRS
CEEECCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
EGFIPPSATSVSHEEVNSYLEPYIEPLNYDTFHFSRKWLQRLTAKATDFRSEEFLESFKT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SRQMNLPPNYLMFFRVLGGLIGIAAQLDAPVDYAAIIDKWVPGFHEDSKAPAAT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALTLPEIDEAPLFVNFITSGHDVRMAEIRRGRAARAAKLASLPAGIAGRAALGVGKRLA
CCCCCCCCCCCEEEEEECCCCCEEHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GKSKDEVNAELVEKAAEQLFQVLGELKGAAMKIGQMLSVMEAAIPPEFGEPYREALTKLQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SDAPPLPADKVHRVLDAQLGTKWRERFQSFDDKPVASASIGQVHKAVWKDGRVVAVKVQY
CCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
PGADEAVRSDLKTIQRLSSLFKQVAPGADIKGIVDELIERTEEELDYRIEATNQRAFAKA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCEEEECCCHHHHHHH
FKGDPEFYVPSVIASSPKVIITEWLQGRKLSEIIASGTEEERSRCAHLLLEFSISSPYRC
HCCCCCEECCHHHHCCCCEEHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEE
GLLHADTHPGNFMLLEDGRFGVMDFGACASHEGGLPAGFGPILRLARDEKWEELTEVLRS
CEEECCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
EGFIPPSATSVSHEEVNSYLEPYIEPLNYDTFHFSRKWLQRLTAKATDFRSEEFLESFKT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SRQMNLPPNYLMFFRVLGGLIGIAAQLDAPVDYAAIIDKWVPGFHEDSKAPAAT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]