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The map label for this gene is adhc1 [H]

Identifier: 169630481

GI number: 169630481

Start: 3448236

End: 3449276

Strand: Direct

Name: adhc1 [H]

Synonym: MAB_3400

Alternate gene names: 169630481

Gene position: 3448236-3449276 (Clockwise)

Preceding gene: 169630480

Following gene: 169630482

Centisome position: 68.05

GC content: 63.02

Gene sequence:

>1041_bases
ATGGTCACCGTGTCGGCTTATGCCGCGACATCCGGTAAGGACCCCCTGGTTCCCACCACGATCGAGCGTCGTGAGGTCGG
TCCCCACGATGTCTTCATCGACATCAAGTTCGCCGGTATCTGTCACTCCGATATCCACACCGTCCGCGACGAGTGGGGAC
GCGCCAACTACCCCATCGTCCCTGGTCATGAGATCGCCGGTGTCATCACCGAGGTAGGCTCCGAGGTAACCAAATTCAAG
CCGGGCGACCACGCCGGCGTCGGCTGCTTCGTCAACTCGTGCCGTGAGTGTCCCAGCTGCCTGGCCGGACTCGAGCAGTT
CTGCGAGCGGGGCATGGTGGGCACCTACGGCGCCAAGGATCGTGACGGCACCCAGACCCAGGGCGGGTACAGCCAGGCCA
TCGTCGTCGACGAGAATTACGTCCTGCGGATCCCCGACAGCCTTCCTCTGGACGCGGCAGCCCCGCTGCTGTGCGCCGGT
ATCACCACCTTCTCACCCCTGCGGCACTGGAATGCCGGCCCCGGCAAGCGCGTGGCGGTCGTCGGGCTGGGCGGCCTGGG
TCACATGGCCGTCAAGCTGGGCAAGGCGATGGGCGCCGAGGTGACGGTGCTGAGCCAGTCACTCAAGAAGATGGAAGACG
GCCTGCGACTGGGTGCCAGCCATTACTACGCGACCGCAGACCCCGACACCTTCAAGTCGCTGCGCAACAGCTTCGACCTA
ATCCTCAACACCGTGTCCTCCAACTTGGATATGGGCAAGTACTTGGGACTGCTGGGCGTTGACGGAACACTGGTGGAGCT
CGGCCTGCCTGAGAACCCGATCGAGGTTCCCGGCTTCCCGCTGCTCACCAACCGGCGCAGCATCTCGGGTTCGTTGATCG
GCGGAATTCCGGAAACCCAAGAGATGCTTGACTTCTGCGCGAAGCACGGCATTGGTTCGGAGATCGAGGTCATCGATGCC
TCGTACATCAACGAGGCCTACGAGCGTGTGGTGGCCAGCGATGTGCGATACCGCTTCGTCATCGATACCCAAACCCTCTG
A

Upstream 100 bases:

>100_bases
CCGGTGGTCTCTATCACCGCTATGAGCCAGGGCGGGAATAAGTGGACCCGAGTAGGCTTTCAATCGGTAGCTTCGTTAAC
TATCGCAAAAGGATGCATAT

Downstream 100 bases:

>100_bases
GACGCTTCGAAATTATCACCCCGAGTACAACCGGTGACTGATGCCGTCGGGGTGCCGATGCTGAGGGGATGACCCGCGTC
ATCCGTTTCAACGCGTTCGA

Product: NADP-dependent alcohol dehydrogenase C

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVTVSAYAATSGKDPLVPTTIERREVGPHDVFIDIKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVGSEVTKFK
PGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAG
ITTFSPLRHWNAGPGKRVAVVGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKSLRNSFDL
ILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDA
SYINEAYERVVASDVRYRFVIDTQTL

Sequences:

>Translated_346_residues
MVTVSAYAATSGKDPLVPTTIERREVGPHDVFIDIKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVGSEVTKFK
PGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAG
ITTFSPLRHWNAGPGKRVAVVGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKSLRNSFDL
ILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDA
SYINEAYERVVASDVRYRFVIDTQTL
>Mature_346_residues
MVTVSAYAATSGKDPLVPTTIERREVGPHDVFIDIKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVGSEVTKFK
PGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAG
ITTFSPLRHWNAGPGKRVAVVGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKSLRNSFDL
ILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDA
SYINEAYERVVASDVRYRFVIDTQTL

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=327, Percent_Identity=30.2752293577982, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI34577061, Length=326, Percent_Identity=29.4478527607362, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501929, Length=326, Percent_Identity=28.8343558282209, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71743840, Length=228, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=228, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71565152, Length=220, Percent_Identity=30.4545454545455, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI71565154, Length=213, Percent_Identity=31.4553990610329, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI156523966, Length=234, Percent_Identity=29.0598290598291, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501939, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=53.448275862069, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=34.9854227405248, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI87081918, Length=340, Percent_Identity=26.1764705882353, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788407, Length=203, Percent_Identity=30.0492610837438, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788073, Length=252, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788075, Length=286, Percent_Identity=24.8251748251748, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=261, Percent_Identity=29.8850574712644, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=195, Percent_Identity=30.2564102564103, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790045, Length=283, Percent_Identity=24.7349823321555, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=318, Percent_Identity=27.3584905660377, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=29.1021671826625, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=321, Percent_Identity=27.7258566978193, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=217, Percent_Identity=29.0322580645161, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=220, Percent_Identity=29.5454545454545, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=183, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=201, Percent_Identity=29.3532338308458, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=38.5579937304075, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319949, Length=339, Percent_Identity=35.9882005899705, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=31.0769230769231, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=30.6501547987616, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=29.0519877675841, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=28.9085545722714, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=233, Percent_Identity=29.6137339055794, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=226, Percent_Identity=29.2035398230088, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=303, Percent_Identity=25.7425742574257, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=27.445652173913, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737897, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37088; Mature: 37088

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVSAYAATSGKDPLVPTTIERREVGPHDVFIDIKFAGICHSDIHTVRDEWGRANYPIV
CEEEEEEECCCCCCCCCCCCCHHCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCCC
PGHEIAGVITEVGSEVTKFKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKD
CCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDGTQTQGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGKRVAV
CCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKSLRNSFDL
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHH
ILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQ
HHHHHHCCCCHHHHHHEECCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCEECCCCCHH
EMLDFCAKHGIGSEIEVIDASYINEAYERVVASDVRYRFVIDTQTL
HHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCEEEEEEECCCC
>Mature Secondary Structure
MVTVSAYAATSGKDPLVPTTIERREVGPHDVFIDIKFAGICHSDIHTVRDEWGRANYPIV
CEEEEEEECCCCCCCCCCCCCHHCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCCC
PGHEIAGVITEVGSEVTKFKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKD
CCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDGTQTQGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGKRVAV
CCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATADPDTFKSLRNSFDL
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHH
ILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQ
HHHHHHCCCCHHHHHHEECCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCEECCCCCHH
EMLDFCAKHGIGSEIEVIDASYINEAYERVVASDVRYRFVIDTQTL
HHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]