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The map label for this gene is ddn [H]

Identifier: 169630473

GI number: 169630473

Start: 3442125

End: 3442637

Strand: Direct

Name: ddn [H]

Synonym: MAB_3392

Alternate gene names: 169630473

Gene position: 3442125-3442637 (Clockwise)

Preceding gene: 169630472

Following gene: 169630474

Centisome position: 67.93

GC content: 63.94

Gene sequence:

>513_bases
GTGAGCGACAACCGATTTCCTGAGAATAGGTGGGGCAACCCCGACAGCACGCTATCCCGGCTCGCGGCCAAGTTCGCCGC
CACCAAGCCGGGTTCGTGGGTCATCCGGAAGCTGACACCACTGGACCGAGCCGTCATGCAGCGCACCGGAAGTCGCTATA
CCGTGCTGGGCCCGCTGGGATTGTCGACCTTGTTGCTCACCACCACCGGCCGCAAGTCCGGGCGGCCCAGGGTATCACCG
CTGCTGTACTTGCACGACGGTGACCGAATTGCATTGGTGGGCAGCAACTTCGGCCAGGAGAAGCACCCGGCGTGGACCGC
CAATCTGCTGGCGGACCCCCGCGCCAAGGTGACGCTGGCCGGCCAAACCATCGAGGTGCTGGCAACTCCCCTCGAGGGCC
CCGAACGCGACGACTACTACCGCCGCTTCGAGTCGATGCTGGAGGTCTACTCGGCCTATAAGGGTCGCACCGGACGGGAA
ATCAGGGTCTTCACCCTCGAACGCATTAACTAA

Upstream 100 bases:

>100_bases
ATGCGCAGGCCCTGATCGCCGCCGATCCCTACACCGCGGCCGGAGTGGCCGAATACACCCGGACCGGTTTCAACGCGGGT
CGCAAAGCAGACATAATCCC

Downstream 100 bases:

>100_bases
AGCTACTCGTTACAGTCAGTACGCGTACTACATGTACCGGTATTAACCAGGATATTTGCCGCGATTTTTCTATAATTACC
CCGATGTCGTCCATTTTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSDNRFPENRWGNPDSTLSRLAAKFAATKPGSWVIRKLTPLDRAVMQRTGSRYTVLGPLGLSTLLLTTTGRKSGRPRVSP
LLYLHDGDRIALVGSNFGQEKHPAWTANLLADPRAKVTLAGQTIEVLATPLEGPERDDYYRRFESMLEVYSAYKGRTGRE
IRVFTLERIN

Sequences:

>Translated_170_residues
MSDNRFPENRWGNPDSTLSRLAAKFAATKPGSWVIRKLTPLDRAVMQRTGSRYTVLGPLGLSTLLLTTTGRKSGRPRVSP
LLYLHDGDRIALVGSNFGQEKHPAWTANLLADPRAKVTLAGQTIEVLATPLEGPERDDYYRRFESMLEVYSAYKGRTGRE
IRVFTLERIN
>Mature_169_residues
SDNRFPENRWGNPDSTLSRLAAKFAATKPGSWVIRKLTPLDRAVMQRTGSRYTVLGPLGLSTLLLTTTGRKSGRPRVSPL
LYLHDGDRIALVGSNFGQEKHPAWTANLLADPRAKVTLAGQTIEVLATPLEGPERDDYYRRFESMLEVYSAYKGRTGREI
RVFTLERIN

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 19076; Mature: 18945

Theoretical pI: Translated: 10.67; Mature: 10.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNRFPENRWGNPDSTLSRLAAKFAATKPGSWVIRKLTPLDRAVMQRTGSRYTVLGPLG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCC
LSTLLLTTTGRKSGRPRVSPLLYLHDGDRIALVGSNFGQEKHPAWTANLLADPRAKVTLA
CEEEEEEECCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEHHHCCCCCEEEEC
GQTIEVLATPLEGPERDDYYRRFESMLEVYSAYKGRTGREIRVFTLERIN
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
SDNRFPENRWGNPDSTLSRLAAKFAATKPGSWVIRKLTPLDRAVMQRTGSRYTVLGPLG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCC
LSTLLLTTTGRKSGRPRVSPLLYLHDGDRIALVGSNFGQEKHPAWTANLLADPRAKVTLA
CEEEEEEECCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEHHHCCCCCEEEEC
GQTIEVLATPLEGPERDDYYRRFESMLEVYSAYKGRTGREIRVFTLERIN
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]