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The map label for this gene is iscS [H]

Identifier: 169630438

GI number: 169630438

Start: 3405289

End: 3406479

Strand: Reverse

Name: iscS [H]

Synonym: MAB_3357c

Alternate gene names: 169630438

Gene position: 3406479-3405289 (Counterclockwise)

Preceding gene: 169630439

Following gene: 169630437

Centisome position: 67.23

GC content: 66.25

Gene sequence:

>1191_bases
ATGTCCCGATCGGTCTACCTGGACCATGCCGCCACCACCCCGATGCGCCCCGATGCCATCGAGGCGATGGCCGCCACCAT
GGCACAGACCGGAAACGCCGCCTCCTTACACGGGGCTGGCCGCGATGCGCGCCGGCGGGTGGAGGAATCGCGTGAGTCGA
TCGCGGCGGCCCTGGGGGCCCGGCCGTCGGAGGTGATCTTCACCGCCGGTGGCACCGAGAGCGACAACCTGGCCGTCAAA
GGCATCTACTGGGCACGCCGCGGCGCTGACGCGCGCCGTCGACGCATCATTGCCAGTGCCGTGGAGCACCACGCCGTGCT
GGATGCTGTGCAGTGGCTCGCCGATCACGAGGGCGCCGCGGTGACCTGGCTGCCCGTCGACCAGGCCGGCACCGTGACGC
CCGGGGCACTGCGCGCAGCTCTTGCCGAGCATGACGACGTCGCACTCATCACAGTGATGTGGGCCAACAATGAGGTCGGC
ACCATCAACCCGATCTACGAATTATCGTCCATTGCAGCAGAATTCGATGTTCCTATGCACAGCGATGCCATTGGTGCGGT
CGGCCAGCTCGACGTCGATTTCGCGCTTAGCGGGCTGTCGGCGATCAGTGTGGCCGCGCACAAATTCGGTGGTCCGATGG
GAGTCGGCGCCTTGCTGCTTCGGCGTGAAATCGCTTGTGTGCCATTGCTACACGGTGGTGGTCACGAACGGGATATCAGG
TCCGGCACGCCCGACACCGCGGCCATCGTGGCGATGTCGACTGCGCTTGTCGCTGCGGTCGCCGAACGGTGCGAGAGCGC
GGCCGCCATGGCCGGACTAAGGGATTCGTTGATCGACCAAGTACTGACACAGATCGAGGGCGCCACCCTCAATGGTGCGC
CCGGCAGCGGCAGGTTGCCCGGGAATGCGCATTTCACCTTTGCCGGATGTGAAGGCGATTCCCTGCTGATGTTATTGGAT
GCCAACGGCATCGAATGCTCGACGGGCTCGGCGTGCACGGCGGGTGTGGCACGCCCGTCGCATGTGCTCATCGAAATGGG
TATAGACCCCGAAGTCGCGCGTGGATCGTTGCGCTTCACCTTCGGGCACACCTCCGTCCCGTCGGACGTGGACCGTGCGC
TCGAGGCGCTTCATGCTGCCGTTCCCCGGGCGCGTGCCGCTGCCCTCGCCAGCGCCGGGGGGCGGTCGTGA

Upstream 100 bases:

>100_bases
GCGGGCCGTCTCACGTGGGAACGCCCGACGTGATGGCGGCGGGCGTGCTCGCCTCCGTCGAATCTGACCTTGGGTATCCG
CCCGCTATCCTGGATGCGTT

Downstream 100 bases:

>100_bases
AAATTCTTGCGGCGATGAGCGGGGGAGTCGACTCCTCGGTGGCTGCCGCCCGCATGGTCGATGCCGGACATGAGGTGGTC
GGCGTGCACCTGGCGTTGTC

Product: putative aminotransferase/cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSRSVYLDHAATTPMRPDAIEAMAATMAQTGNAASLHGAGRDARRRVEESRESIAAALGARPSEVIFTAGGTESDNLAVK
GIYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAAVTWLPVDQAGTVTPGALRAALAEHDDVALITVMWANNEVG
TINPIYELSSIAAEFDVPMHSDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRREIACVPLLHGGGHERDIR
SGTPDTAAIVAMSTALVAAVAERCESAAAMAGLRDSLIDQVLTQIEGATLNGAPGSGRLPGNAHFTFAGCEGDSLLMLLD
ANGIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFTFGHTSVPSDVDRALEALHAAVPRARAAALASAGGRS

Sequences:

>Translated_396_residues
MSRSVYLDHAATTPMRPDAIEAMAATMAQTGNAASLHGAGRDARRRVEESRESIAAALGARPSEVIFTAGGTESDNLAVK
GIYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAAVTWLPVDQAGTVTPGALRAALAEHDDVALITVMWANNEVG
TINPIYELSSIAAEFDVPMHSDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRREIACVPLLHGGGHERDIR
SGTPDTAAIVAMSTALVAAVAERCESAAAMAGLRDSLIDQVLTQIEGATLNGAPGSGRLPGNAHFTFAGCEGDSLLMLLD
ANGIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFTFGHTSVPSDVDRALEALHAAVPRARAAALASAGGRS
>Mature_395_residues
SRSVYLDHAATTPMRPDAIEAMAATMAQTGNAASLHGAGRDARRRVEESRESIAAALGARPSEVIFTAGGTESDNLAVKG
IYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAAVTWLPVDQAGTVTPGALRAALAEHDDVALITVMWANNEVGT
INPIYELSSIAAEFDVPMHSDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRREIACVPLLHGGGHERDIRS
GTPDTAAIVAMSTALVAAVAERCESAAAMAGLRDSLIDQVLTQIEGATLNGAPGSGRLPGNAHFTFAGCEGDSLLMLLDA
NGIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFTFGHTSVPSDVDRALEALHAAVPRARAAALASAGGRS

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=387, Percent_Identity=35.9173126614987, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI156713448, Length=420, Percent_Identity=31.4285714285714, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI48994898, Length=393, Percent_Identity=35.6234096692112, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1787970, Length=397, Percent_Identity=25.6926952141058, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789175, Length=415, Percent_Identity=29.1566265060241, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=34.1085271317829, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17533177, Length=319, Percent_Identity=27.8996865203762, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=388, Percent_Identity=36.0824742268041, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129463, Length=387, Percent_Identity=34.625322997416, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40850; Mature: 40718

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVYLDHAATTPMRPDAIEAMAATMAQTGNAASLHGAGRDARRRVEESRESIAAALGA
CCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHCC
RPSEVIFTAGGTESDNLAVKGIYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAA
CCCEEEEECCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VTWLPVDQAGTVTPGALRAALAEHDDVALITVMWANNEVGTINPIYELSSIAAEFDVPMH
EEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
SDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRREIACVPLLHGGGHERDIR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCC
SGTPDTAAIVAMSTALVAAVAERCESAAAMAGLRDSLIDQVLTQIEGATLNGAPGSGRLP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GNAHFTFAGCEGDSLLMLLDANGIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFT
CCCEEEEEECCCCCEEEEEECCCCEECCCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEE
FGHTSVPSDVDRALEALHAAVPRARAAALASAGGRS
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRSVYLDHAATTPMRPDAIEAMAATMAQTGNAASLHGAGRDARRRVEESRESIAAALGA
CCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHCC
RPSEVIFTAGGTESDNLAVKGIYWARRGADARRRRIIASAVEHHAVLDAVQWLADHEGAA
CCCEEEEECCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VTWLPVDQAGTVTPGALRAALAEHDDVALITVMWANNEVGTINPIYELSSIAAEFDVPMH
EEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
SDAIGAVGQLDVDFALSGLSAISVAAHKFGGPMGVGALLLRREIACVPLLHGGGHERDIR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCC
SGTPDTAAIVAMSTALVAAVAERCESAAAMAGLRDSLIDQVLTQIEGATLNGAPGSGRLP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCC
GNAHFTFAGCEGDSLLMLLDANGIECSTGSACTAGVARPSHVLIEMGIDPEVARGSLRFT
CCCEEEEEECCCCCEEEEEECCCCEECCCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEE
FGHTSVPSDVDRALEALHAAVPRARAAALASAGGRS
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA