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The map label for this gene is serA [H]

Identifier: 169630385

GI number: 169630385

Start: 3342669

End: 3344240

Strand: Reverse

Name: serA [H]

Synonym: MAB_3304c

Alternate gene names: 169630385

Gene position: 3344240-3342669 (Counterclockwise)

Preceding gene: 169630386

Following gene: 169630384

Centisome position: 66.0

GC content: 66.92

Gene sequence:

>1572_bases
GTGTTGATTGCCGACAAACTTGCCCCGTCGACCGTCGAAGCACTCGGAGATGGTGTGGAGGTGCGCTGGGTCGATGGCCC
TGACCGCCCCGCGCTGCTGGCCGCGGTACCCGAGGCTGATGCGCTTCTGGTGCGCTCGGCCACCACGGTTGACGCCGAGG
TGCTGGCCGCCGGAACCAAGCTCAAGATCGTCGCGCGTGCCGGCGTCGGACTCGACAATGTCGACGTCAAGGCCGCCACT
GCCCGTGGTGTTCTGGTGGTCAACGCCCCCACCTCGAACATCCACAGCGCGGCCGAGCACGCCGTGACCCTGCTGCTGGC
CACCGCGCGGCAGATCCCGGCGGCTGACGCCTCGCTCAAGGCGCACACCTGGAAGCGCTCGTCGTTCAACGGCACCGAGA
TATTCGGTAAGACCGTCGGCGTCGTGGGCCTGGGCCGCATCGGGCAGTTGTTCGCGCAGCGGCTCGCCGCGTTCGGCACG
CACATCGTCGCGTACGACCCCTACGTCTCGGCCGCTCGTGCTGCCCAGCTCGGTATCGAACTGCTGACACTCGACGAACT
TTTGGGTCGGGCAGATTTCATTTCGGTGCACCTGCCCAAGACGCCGGAGACCGCGGGCCTGATCGGCAAGGAGGCCCTCG
CCAAGACCAAGCCGGGTGTCATCATCGTCAATGCCGCGCGCGGTGGGCTCATCGACGAGGCAGCCCTGGCCGATGCCATT
CGTAGTGGTCACGTCCGCGGCGCCGGCCTCGACGTGTTCTCCACCGAGCCGTGCACCGACAGCCCGCTGTTCGAACTCGA
CCAGGTGGTGGTGACCCCGCACCTGGGCGCCTCCACCAGCGAGGCGCAGGATCGCGCGGGCACCGACGTGGCCGCAAGCG
TGCAGCTGGCCCTGGCGGGCGAGTTCGTGCCGGACGCCGTCAACGTCGGCGGGGGCGTCGTCAGCGAAGAGGTGGCGCCG
TGGCTTGAGGTGGTGCGCAAGCTCGGCGTGCTCATCGGAGCCGTTTCCGAGCAGCTGCCTACCTCGTTGTCGGTTGATGT
CCGCGGTGAGTTGGCTTCCGAAGATGTTGCGGTGCTGAAGCTTTCCGCGTTGCGTGGACTGTTCTCGTCGGTGATCGAGG
ACCAGGTGACGTTCGTGAACGCTCCGTCGATCGCCGAAGAGCGTGGCGTGAGTGCGGAGATCACCACGGCCACCGAGAGC
CCGAACCACCGCAGTGTCGTCGATGTGCGCGCCGTGTATGCCGACGGCTCCGTGATCAACGTCGCCGGCACCTTGTCAGG
CCCGCAACTGGTGCAAAAGATCGTCCAGATCAACGGTCGCAACTTCGATCTGCGTGCCGAGGGCGTCAACCTCGTCATCA
ACTACGCGGACGTGCCGGGCGCCCTGGGCAAGATCGGCACCGTGCTGGGTGGCGCCGAGGTGAACATCCAGGCCGCGCAG
CTGAGCCAGGACGCCTCCGGTGCGGCAGCCACCATCATCCTGCGCATTGATCGCACTGCTCCGGATGCCGTGCTGGACGA
GATCCGTGCCGCCGTCGGCGCGACGACCCTTGAGCTGGTGGATCTTTCATGA

Upstream 100 bases:

>100_bases
CTACGCGCGGTGGCGACGCAGATCGGGTACTAGACCAGGTGTGATGTAAGCCTCCTGATGGTCCGCACTAGGCTGTGACG
ACGTGAGCGAACGTCCAGTC

Downstream 100 bases:

>100_bases
CCAAACTCGCGATCATCGCCGGTGATGGCATCGGTCCTGAGGTCATCGGCGAGGCCGTGAAGGTGCTGGATGCGGTACTG
CCGGGCGTCGACAAGACCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAAT
ARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKAHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGT
HIVAYDPYVSAARAAQLGIELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAP
WLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATES
PNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQ
LSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS

Sequences:

>Translated_523_residues
MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAAT
ARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKAHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGT
HIVAYDPYVSAARAAQLGIELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAP
WLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATES
PNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQ
LSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
>Mature_523_residues
MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAAT
ARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKAHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGT
HIVAYDPYVSAARAAQLGIELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAP
WLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATES
PNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQ
LSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=408, Percent_Identity=38.2352941176471, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=32.3843416370107, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=32.3843416370107, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI145580578, Length=297, Percent_Identity=32.3232323232323, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=297, Percent_Identity=32.3232323232323, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=34.2960288808664, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI145580575, Length=298, Percent_Identity=31.5436241610738, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1789279, Length=272, Percent_Identity=34.9264705882353, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=38.7096774193548, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=36.734693877551, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081824, Length=273, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788660, Length=269, Percent_Identity=31.9702602230483, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=45.945945945946, Blast_Score=264, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI25147481, Length=283, Percent_Identity=32.8621908127208, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=32.1311475409836, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322116, Length=278, Percent_Identity=32.3741007194245, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=36.144578313253, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=26.1992619926199, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=30.6818181818182, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=24.7422680412371, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=326, Percent_Identity=44.1717791411043, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=36.5591397849462, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28574286, Length=303, Percent_Identity=31.6831683168317, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=32.7272727272727, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=32.7272727272727, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=32.7272727272727, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=32.7272727272727, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=32.7272727272727, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=30, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45551003, Length=281, Percent_Identity=32.0284697508897, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 53802; Mature: 53802

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLAAGTK
CCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEEECCCCCCHHHHCCCCE
LKIVARAGVGLDNVDVKAATARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLK
EEEEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
AHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLGIE
EEEEECCCCCCCEECCCCCCEEECHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCEE
LLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
EEEHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAG
HCCCCCCCCCEEECCCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCCCHHHEEEEEEEC
EFVPDAVNVGGGVVSEEVAPWLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLK
CCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
LSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVIN
HHHHHHHHHHHHHCCEEEECCCCCHHHCCCCEEEEECCCCCCCCCEEEEEEEEECCCEEE
VAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQ
EEECCCCHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCCCEEEEEHHH
LSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECC
>Mature Secondary Structure
MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVRSATTVDAEVLAAGTK
CCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEEEECCCCCCHHHHCCCCE
LKIVARAGVGLDNVDVKAATARGVLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLK
EEEEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
AHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLGIE
EEEEECCCCCCCEECCCCCCEEECHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCEE
LLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
EEEHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAG
HCCCCCCCCCEEECCCCCCCCCHHHCCCEEEECCCCCCCCCHHHHCCCCHHHEEEEEEEC
EFVPDAVNVGGGVVSEEVAPWLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLK
CCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
LSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVIN
HHHHHHHHHHHHHCCEEEECCCCCHHHCCCCEEEEECCCCCCCCCEEEEEEEEECCCEEE
VAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQ
EEECCCCHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCCCEEEEEHHH
LSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]