Click here to switch to the map view.

The map label for this gene is hmp [H]

Identifier: 169630215

GI number: 169630215

Start: 3173471

End: 3174712

Strand: Reverse

Name: hmp [H]

Synonym: MAB_3133c

Alternate gene names: 169630215

Gene position: 3174712-3173471 (Counterclockwise)

Preceding gene: 169630216

Following gene: 169630214

Centisome position: 62.65

GC content: 61.11

Gene sequence:

>1242_bases
GTGGACGGTGGCCGAAATAGCCCGTCCAACAATGGAAAGGAAGTAGTCAAAGTGCTATCAGCAGAGTCGCTGGGAGTCAT
CCGTGAAACGCTGCCCGCCGTGGCGGGTGCGATCGATGAGATCACGCCGTTGTTCTACTCCAAGATGTTCGCGGCGCATC
CGGAACTTCTTCGCGATCTGTTCAACCGTGGAAATCAGGCGGCAGGGGAGCAGCCGAAGGCGCTGGCCGCATCCATTGCG
GCATTCGCCGGAATGGTGTTGGAAGGCAATGGAGCTCAGTATGACTCGGTGCTCGACAGGATTGCTCACAAGCATGCCTC
ATTGGGCATCGTCGCCGAGCAGTATCCGATTGTGTACGAGCACCTGTTCGCCGCGATCGCGGAGGTGCTGGGCGGGGCGG
TGACCGCCGATGTCGCCAAGGCCTGGAGTGAGTTCTACTGGCTGATGGCCGACGAATTGATCGCTCGGGAAAAGGCGCTC
TACGACGCCGCCGGGGTAGCGCCGGGGGACGTGTGGCTCCAGGCCATAGTGGTGCGCCGCCAGTTGGAATCAGCGGACGT
GGCCGGATTCGAGTTACGCGGTGTGTCCGGTAAATTGCCGAATTTTGTACCGGGACAGTACATATCGGTACAAGTCACCT
TGCCGGACGGGGCCAGGCAGATCCGGCAATACAGTTTGTCGCGCGGATCCACAGCGGGAGACTGGCGTATTGCCGTCAAG
CGACTGAACGTCGGTGACACCCCCGCGGGTGAGGTGTCGAATTTCATCTACGACAACGTCTTTGAAGGACAACAACTGCG
GGTTTCGGTGCCCATGGGTGAGTTCACGCTCGATGACTCGGCGGATCCGTTGGTTCTCGTATCGGCGGGGATCGGCTGCA
CGCCGATCATGGGAATGCTGCAAGAGCTCGTGGCCACGCAGTCGCCGCGTGAAGTCGTGGTCCTCCACGCGGACCAGTCG
GCCGCCGCACACGCATATCGGCACGAGCTGGCAGACCTGGTGGGTCGTTTGCCCGCAGGGCGGCTACACACCTGGTACGA
ACGGGCACATGTCGAGCATCCGGCTGATGGAATTGGGCGCATGAGCCTGGACCGCCTTCCGATCGATCTCTCGTCCACGG
TGTTCGTCTGCGGCCCCCGGCCGTTCATGTCGGCAATCAACGAGGACTTGGTGTCACTCGGTATCCCTCAGGAGCAGATC
AATCACGAGCTGTTCGGTCCATTGGCGTCGGCCGTGGCATGA

Upstream 100 bases:

>100_bases
TCGACTGCGAGGGGGATCCGCCCTGTCCTCTCCGCAGGAATTGCCGTCTTCGTGAGGCGCTTCGCTCCGCCCAAGACGCG
TTCTTCACTCACCTCGATCA

Downstream 100 bases:

>100_bases
CGCGCGTCGAGGTGCTGACGGCGGCGCTGGCGGCATTCTGGCTTGGGTTGGTGGTGGCGATCTCGTTTATCGAGGCGCCA
CTGAAGTTCCGCGCGCCGGG

Product: putative flavohemoprotein

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDLFNRGNQAAGEQPKALAASIA
AFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYEHLFAAIAEVLGGAVTADVAKAWSEFYWLMADELIAREKAL
YDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKLPNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVK
RLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSADPLVLVSAGIGCTPIMGMLQELVATQSPREVVVLHADQS
AAAHAYRHELADLVGRLPAGRLHTWYERAHVEHPADGIGRMSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQI
NHELFGPLASAVA

Sequences:

>Translated_413_residues
MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDLFNRGNQAAGEQPKALAASIA
AFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYEHLFAAIAEVLGGAVTADVAKAWSEFYWLMADELIAREKAL
YDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKLPNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVK
RLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSADPLVLVSAGIGCTPIMGMLQELVATQSPREVVVLHADQS
AAAHAYRHELADLVGRLPAGRLHTWYERAHVEHPADGIGRMSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQI
NHELFGPLASAVA
>Mature_413_residues
MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDLFNRGNQAAGEQPKALAASIA
AFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYEHLFAAIAEVLGGAVTADVAKAWSEFYWLMADELIAREKAL
YDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKLPNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVK
RLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSADPLVLVSAGIGCTPIMGMLQELVATQSPREVVVLHADQS
AAAHAYRHELADLVGRLPAGRLHTWYERAHVEHPADGIGRMSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQI
NHELFGPLASAVA

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1017

COG function: function code C; Hemoglobin-like flavoprotein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=406, Percent_Identity=33.743842364532, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1787658, Length=217, Percent_Identity=25.3456221198157, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787098, Length=219, Percent_Identity=28.7671232876712, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788104, Length=228, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321673, Length=410, Percent_Identity=30.9756097560976, Blast_Score=166, Evalue=6e-42,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR001709
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR001834
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 44372; Mature: 44372

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FNRGNQAAGEQPKALAASIAAFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYE
HHCCCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHCCEEHHHCHHHHH
HLFAAIAEVLGGAVTADVAKAWSEFYWLMADELIAREKALYDAAGVAPGDVWLQAIVVRR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLESADVAGFELRGVSGKLPNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVK
HHHCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEE
RLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSADPLVLVSAGIGCTPIMGML
EECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEECCCCHHHHHHHH
QELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYERAHVEHPADGIGR
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
MSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQINHELFGPLASAVA
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FNRGNQAAGEQPKALAASIAAFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYE
HHCCCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHCCEEHHHCHHHHH
HLFAAIAEVLGGAVTADVAKAWSEFYWLMADELIAREKALYDAAGVAPGDVWLQAIVVRR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLESADVAGFELRGVSGKLPNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVK
HHHCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEE
RLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSADPLVLVSAGIGCTPIMGML
EECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEECCCCHHHHHHHH
QELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYERAHVEHPADGIGR
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
MSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQINHELFGPLASAVA
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10484179; 11058132 [H]