Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 169630182

GI number: 169630182

Start: 3143072

End: 3144187

Strand: Direct

Name: ald [H]

Synonym: MAB_3100

Alternate gene names: 169630182

Gene position: 3143072-3144187 (Clockwise)

Preceding gene: 169630180

Following gene: 169630192

Centisome position: 62.03

GC content: 64.43

Gene sequence:

>1116_bases
ATGCGCGTAGGCATCCCTACCGAGATCAAGAACAACGAATATCGCGTGGCCACCACACCCGCGGGTGTGGCCGAACTGAC
CCGTCGCGGGCACGAGGTGATCATTCAGTCGGGCGCGGGTGACGGCTCCTCGATATCGGATGTGGACTTCAAAGCCGCTG
GCGCACAGGTGATCAACGGCGCCGAACAGGTTTGGGCCGAGGCCGATCTGCTACTCAAGGTCAAGGAACCGATCGAGCCC
GAATACGCCCTCATGCGTCGTGGCCAGACGCTCTTCACCTACCTGCACCTGGCCGCCTCGCTGCCGTGCACGCAGGCGTT
ACTGAAGTCAGAAACCACCTCGATCGCGTACGAGACAGTGCAGACCTCCGACGGTGCGCTCCCCCTACTGGCCCCTATGA
GTGAGGTCGCCGGACGGTTGGCCGCACAGGTCGGGGCGTACCACCTGATGACCCCCGTGGGGGGACGCGGCCTGGTCATG
GGTGGTGTGCCTGGAGTCGGCCCGGCCGACGTGGTCGTGATCGGTGGTGGCGTCGCCGGATACAACGCGGCACGCATCGC
CGCCGGAATGGGTGCTCACGTCACCGTTTTCGACGTCAACTTGGGCAAGCTGCGGGAGCTGGACGGAGAGTTCGGCGGCA
CTATCCGTACCCGGTACTCGTCGACCATGGAGCTGGAAGGCGCCGTCAAACGCGCCGACCTGGTGATCGGAGCCGTGCTC
ATCCCGGGCGCCAAGGCTCCTAAACTCATTTCGAATTCCCTTGTTTCTCAAATGAAACCGGGTTCAGTGCTCGTGGACAT
CGCCATCGATCAGGGGGGCTGCTTCGCCGATTCACGCCCCACCACTCATGACGAACCGACCTACACCGTCCACGACAGCG
TGTTCTACTGCGTGGCCAATATGCCCGGCGCGGTGCCACGGACCTCCACCTTTGCCCTGACCAACGCCACCATGCCGTAC
GTGCTGGCACTGGCAGACAAGGGCTGGCGCCAGGCCTGCCGCGACGACGCCGCGCTCGCCCAGGGACTCTCCACACATGA
GGGCGCGCTACTGAACACGCATGTCGCACACGACCTGGGGCTGGCCTTCACCGATCCTGCCGAGGTCCTCGGGTAG

Upstream 100 bases:

>100_bases
TTTGCAATCTACCGAATCTTCCACGGAAATATTGCGCGTTTATCGACGCTTCTTCACACTTGAACGCGGGACTTAGTTTT
GAAACAGGAGAAGAAGAATC

Downstream 100 bases:

>100_bases
CTATTCGTAGATCACGACGGCAATCACGCTGTCATCGGTGATCTAGACAGCGGTCTGCGCGGTGAGGTCATTGGTCCACG
TGGGCGTTTTGATCTTCTTG

Product: L-alanine dehydrogenase (ALD)

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDFKAAGAQVINGAEQVWAEADLLLKVKEPIEP
EYALMRRGQTLFTYLHLAASLPCTQALLKSETTSIAYETVQTSDGALPLLAPMSEVAGRLAAQVGAYHLMTPVGGRGLVM
GGVPGVGPADVVVIGGGVAGYNAARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSSTMELEGAVKRADLVIGAVL
IPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRPTTHDEPTYTVHDSVFYCVANMPGAVPRTSTFALTNATMPY
VLALADKGWRQACRDDAALAQGLSTHEGALLNTHVAHDLGLAFTDPAEVLG

Sequences:

>Translated_371_residues
MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDFKAAGAQVINGAEQVWAEADLLLKVKEPIEP
EYALMRRGQTLFTYLHLAASLPCTQALLKSETTSIAYETVQTSDGALPLLAPMSEVAGRLAAQVGAYHLMTPVGGRGLVM
GGVPGVGPADVVVIGGGVAGYNAARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSSTMELEGAVKRADLVIGAVL
IPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRPTTHDEPTYTVHDSVFYCVANMPGAVPRTSTFALTNATMPY
VLALADKGWRQACRDDAALAQGLSTHEGALLNTHVAHDLGLAFTDPAEVLG
>Mature_371_residues
MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDFKAAGAQVINGAEQVWAEADLLLKVKEPIEP
EYALMRRGQTLFTYLHLAASLPCTQALLKSETTSIAYETVQTSDGALPLLAPMSEVAGRLAAQVGAYHLMTPVGGRGLVM
GGVPGVGPADVVVIGGGVAGYNAARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSSTMELEGAVKRADLVIGAVL
IPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRPTTHDEPTYTVHDSVFYCVANMPGAVPRTSTFALTNATMPY
VLALADKGWRQACRDDAALAQGLSTHEGALLNTHVAHDLGLAFTDPAEVLG

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=308, Percent_Identity=34.7402597402597, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI122939153, Length=308, Percent_Identity=34.7402597402597, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1787887, Length=332, Percent_Identity=33.7349397590361, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17550456, Length=362, Percent_Identity=32.5966850828729, Blast_Score=144, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38706; Mature: 38706

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDFKAAGAQVING
CCCCCCCCCCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHCCHHHHCC
AEQVWAEADLLLKVKEPIEPEYALMRRGQTLFTYLHLAASLPCTQALLKSETTSIAYETV
HHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEE
QTSDGALPLLAPMSEVAGRLAAQVGAYHLMTPVGGRGLVMGGVPGVGPADVVVIGGGVAG
ECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCC
YNAARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSSTMELEGAVKRADLVIGAVL
CCHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHEEEEEEE
IPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRPTTHDEPTYTVHDSVFYCVAN
ECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEEC
MPGAVPRTSTFALTNATMPYVLALADKGWRQACRDDAALAQGLSTHEGALLNTHVAHDLG
CCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHCC
LAFTDPAEVLG
CEECCHHHHCC
>Mature Secondary Structure
MRVGIPTEIKNNEYRVATTPAGVAELTRRGHEVIIQSGAGDGSSISDVDFKAAGAQVING
CCCCCCCCCCCCCEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHCCHHHHCC
AEQVWAEADLLLKVKEPIEPEYALMRRGQTLFTYLHLAASLPCTQALLKSETTSIAYETV
HHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEE
QTSDGALPLLAPMSEVAGRLAAQVGAYHLMTPVGGRGLVMGGVPGVGPADVVVIGGGVAG
ECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCC
YNAARIAAGMGAHVTVFDVNLGKLRELDGEFGGTIRTRYSSTMELEGAVKRADLVIGAVL
CCHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHEEEEEEE
IPGAKAPKLISNSLVSQMKPGSVLVDIAIDQGGCFADSRPTTHDEPTYTVHDSVFYCVAN
ECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEEC
MPGAVPRTSTFALTNATMPYVLALADKGWRQACRDDAALAQGLSTHEGALLNTHVAHDLG
CCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHCC
LAFTDPAEVLG
CEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]