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The map label for this gene is thyX

Identifier: 169630168

GI number: 169630168

Start: 3131072

End: 3131824

Strand: Reverse

Name: thyX

Synonym: MAB_3085c

Alternate gene names: 169630168

Gene position: 3131824-3131072 (Counterclockwise)

Preceding gene: 169630170

Following gene: 169630167

Centisome position: 61.81

GC content: 65.21

Gene sequence:

>753_bases
GTGGCAGAGATCGTGCCGCTGCGCGTGCAGCTGATAGCGAAGACCGACTTCATCGCACCTCCGGATATCGACTGGAGCAC
CGATGCCGACGGTGGACCGGCGCTCGTCGAGTTCGCCGGCCGTGCCTGCTACCAGAGCTGGTCCAAGCCGAACCCGCGCA
CCGCCACCAACGAGAGTTACCTGCGCCATGTCATCGAGGTCGGGCACCTGTCGGTGCTCGAGCATGCGTCGGCGACCTTC
TACATCACCGGTATCTCGCGGTCCTGTACTCACGAGTTGATCCGGCATCGCCACTTCTCGTACTCGCAGCTCTCCCAGCG
ATTCGTCCCGGAGGACGACTCGAACGTCGTGCTGCCCCCCGCTGTCGAGGACGACCCGGAACTCGTCGCGCTGGTGCGTA
AGGCCACAGATGCCAGCCGCGCGGCGTATGTCGAGCTGCTGGAGAAATTGGAATCCACACTGGCCGACGTTCCCAACGCG
GTGCTGCGGCGCAAGCAGGCACGCCAGGCCGCCCGGTCCGTGCTGCCCAACGCTACGGAGACCAGGATCGTCGTCACCGG
GAACTACCGGGCCTGGCGACACTTCATCGCGATGAGGGCCAGCGAACACGCCGACGTGGAGATTCGTCGGCTCGCCATTG
CCTGTCTGCGCCAGCTCGCCGACCTGGCTCCGTCCATCTTCGGAGATTTCGATATCGCGACCCTGGCCGACGGCACGGAG
GTCGCGATCTCCCCATTGGTCTACGAGGGGTAG

Upstream 100 bases:

>100_bases
GAAACACCGCGAGCATGCGCAAAATTGCGGATTTCGCCCGTTTTGGCGCACATTTCAGCATGTTCGTGGGGACGGCGACG
GTACACGTAGGGTGTTGCGC

Downstream 100 bases:

>100_bases
AACCGAGGGATACAACCGAGGGATACAACCGAGGGATACAACACAGCCGGTAGGGATTAACCGCTTGGTTGGGGCGGGTA
TTCTCATGCCGTGACAGCAG

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESYLRHVIEVGHLSVLEHASATF
YITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPPAVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNA
VLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTE
VAISPLVYEG

Sequences:

>Translated_250_residues
MAEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESYLRHVIEVGHLSVLEHASATF
YITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPPAVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNA
VLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTE
VAISPLVYEG
>Mature_249_residues
AEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESYLRHVIEVGHLSVLEHASATFY
ITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPPAVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNAV
LRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTEV
AISPLVYEG

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_MYCA9 (B1MD42)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703817.1
- ProteinModelPortal:   B1MD42
- SMR:   B1MD42
- EnsemblBacteria:   EBMYCT00000007617
- GeneID:   5965592
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3085c
- GeneTree:   EBGT00050000016797
- HOGENOM:   HBG458114
- OMA:   RATEHAD
- ProtClustDB:   PRK00847
- BioCyc:   MABS561007:MAB_3085C-MONOMER
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 27688; Mature: 27556

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESY
CCCCCHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LRHVIEVGHLSVLEHASATFYITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPP
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEECC
AVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNAVLRRKQARQAARSVLPNATE
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTE
CEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCC
VAISPLVYEG
EEECCEEECC
>Mature Secondary Structure 
AEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESY
CCCCHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
LRHVIEVGHLSVLEHASATFYITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPP
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEECC
AVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNAVLRRKQARQAARSVLPNATE
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTE
CEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCC
VAISPLVYEG
EEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA