Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 169630073

GI number: 169630073

Start: 3050123

End: 3052048

Strand: Reverse

Name: dxs

Synonym: MAB_2990c

Alternate gene names: 169630073

Gene position: 3052048-3050123 (Counterclockwise)

Preceding gene: 169630074

Following gene: 169630069

Centisome position: 60.23

GC content: 64.95

Gene sequence:

>1926_bases
ATGCTTGACGACATCAGGGGGCCGGGTGACCTGCAGGGTCTCTCGAAGCGAGAACTGGACTTGCTCGCTGACGAGATCCG
CGAGTTCCTGATCCATAAGGTCGCCGCGACCGGTGGGCATCTTGGCCCCAACCTGGGTGTTGTCGAGCTGAGTCTGGCAC
TGCATCGGGTTTTCGAGTCGCCGTACGACCCGATCATCTTTGACACCGGGCATCAGGCCTACGTCCACAAGATTCTGACC
GGCCGGGCCGGAGACTTCGACACCTTGCGCCAAAAGGACGGTCTGTCGGGATATCCGTCACGGGCCGAGAGCGAACACGA
CTGGGTGGAATCGAGCCACGCGTCGACGGCGCTGTCCTACGCCGACGGACTTGCCAAGGCGTTCGAGCTGACGGGGCAGC
GACGGCGCCATGTCGTCGCGGTGGTCGGCGACGGTGCCATGACCGGAGGCATGTGCTGGGAGGCCCTCAACAACATCGCC
GCCGCCGAGCATCGGCGCATCATCATCGTCGTCAACGACAATGGGCGTAGCTACGCGCCGACCATCGGCGGGCTCGCCTC
GCATCTGGCGGGGCTGCGGCTCACCCCTTCCTACGAGAAGGTCCTCGACGAGAGCAAGAAGCTGCTGCGTGGCATGCCGG
TCGTGGGTCCGCTGGCCTACGCCCTGATGCACAGCCTCAAGGTCGGGGTGAAGGATGCGGTGTCGCCGCAGGTGATGTTC
ACCGACCTGGGGCTGAAATATGTCGGTCCGGTTGACGGTCATGATGAGCACGCTGTGGAGGATGCTCTGCGCCGTGCCCG
TGGCTACGGCGGTCCGGTGATCGTGCACGTGATCACTCGCAAGGGCATGGGATACGCCCCCGCCGAGGACGACGAGGCCG
AGCAGATGCATTCCACCGGCATTATCGACCCGAAAACCGGTCGGGCTATTAAGGCTTCGGCTCCGGGTTGGACTTCGGTG
TTCTCCGATGCGCTCATCGATGTGGCCAGTGAGCATCGCAATATCGTGGCGATCACCGCGGCCATGCCGGGCCCGACCGG
GCTCAGTAAGTTCGGTGAGCGCTTCCCCGATCGGCTGTTCGACGTCGGTATTGCCGAGCAACATGCCGTCACCTCCGCGG
CCGGGCTCGCCATGGGCGGTTTGCATCCCGTGGTCGCGATCTACTCCACGTTCCTGAACCGCGCGTTTGATCAGGTGATG
ATGGATGTCGCGCTGCACCGGCTTCCCGTGACCTTCGTGCTGGACCGCGCGGGAATCACCGGCAGCGACGGGGCCAGCCA
CAACGGTATGTGGGATTTGTCGATCCTGAATGTGGTGCCCGGAATGCGGGTCGCGGCGCCGCGCGATGCTTCGCGGCTGC
GCGAGGAGCTGACTGAAGCCCTGGCCGTCGATGACGGTCCGACCGCCTTGCGTTTCCCGAAAGGTGAAGTCGGGGAGGAT
ATCCCGGCAATCGAGCGACGTGATGGGGTAGACATCCTGGCCCGTCCGGCCAGTGGTTTACATGCCGACGTGCTACTGGT
GGCGGTCGGGTCGTTCGCGTCGACAGCCTTGGCGACAGCGGACAGGCTCGGCAAGCAGGGGATCGGCGTTACGGTCGTCG
ATCCGCGGTGGGTGCTGCCGGTACCGCCGCATGTGGTGGAACTGGCCGGCCAACATCGTCTGGTGGTCACCCTGGAGGAC
AGCGGCGTGCACGGCGGCGCCGGCAGCGCGGTAACGGCGGCGATGCAGGATGCCGATGTCGATATCCCGAGCCGGGATAT
CGGTGTGCCGCAGCAGTTCCTGGAGCATGCGTCGCGTGGTCAGGTTCTCGAAGAGCTCGGTCTCACCGATCAGCACATCG
CCCGCAAGATCACCGGCTGGGTGGCCGCGATGAGCCGCGAAATCGGAGACAGCACCGTGAACCCCGCCGCGCAGCAGGTC
GACTAG

Upstream 100 bases:

>100_bases
CGAGGCCAAGGAGACTCTTGACGCCGATCACGACGGGGTACCCGATGTTTTTGGCTCTGCTCCAGGCGACCGGATCTAAA
TCGCTGCGTAGACTGGCCAG

Downstream 100 bases:

>100_bases
TCCCGGACCCAATCCGGATCGGCGATGATTTGGCGGAGCTCCTCGACCAAGCGTGCGCTGTGATAGCCATCGGCGGCCGC
GTGATGAATCTGTAGGGCTA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MLDDIRGPGDLQGLSKRELDLLADEIREFLIHKVAATGGHLGPNLGVVELSLALHRVFESPYDPIIFDTGHQAYVHKILT
GRAGDFDTLRQKDGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELTGQRRRHVVAVVGDGAMTGGMCWEALNNIA
AAEHRRIIIVVNDNGRSYAPTIGGLASHLAGLRLTPSYEKVLDESKKLLRGMPVVGPLAYALMHSLKVGVKDAVSPQVMF
TDLGLKYVGPVDGHDEHAVEDALRRARGYGGPVIVHVITRKGMGYAPAEDDEAEQMHSTGIIDPKTGRAIKASAPGWTSV
FSDALIDVASEHRNIVAITAAMPGPTGLSKFGERFPDRLFDVGIAEQHAVTSAAGLAMGGLHPVVAIYSTFLNRAFDQVM
MDVALHRLPVTFVLDRAGITGSDGASHNGMWDLSILNVVPGMRVAAPRDASRLREELTEALAVDDGPTALRFPKGEVGED
IPAIERRDGVDILARPASGLHADVLLVAVGSFASTALATADRLGKQGIGVTVVDPRWVLPVPPHVVELAGQHRLVVTLED
SGVHGGAGSAVTAAMQDADVDIPSRDIGVPQQFLEHASRGQVLEELGLTDQHIARKITGWVAAMSREIGDSTVNPAAQQV
D

Sequences:

>Translated_641_residues
MLDDIRGPGDLQGLSKRELDLLADEIREFLIHKVAATGGHLGPNLGVVELSLALHRVFESPYDPIIFDTGHQAYVHKILT
GRAGDFDTLRQKDGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELTGQRRRHVVAVVGDGAMTGGMCWEALNNIA
AAEHRRIIIVVNDNGRSYAPTIGGLASHLAGLRLTPSYEKVLDESKKLLRGMPVVGPLAYALMHSLKVGVKDAVSPQVMF
TDLGLKYVGPVDGHDEHAVEDALRRARGYGGPVIVHVITRKGMGYAPAEDDEAEQMHSTGIIDPKTGRAIKASAPGWTSV
FSDALIDVASEHRNIVAITAAMPGPTGLSKFGERFPDRLFDVGIAEQHAVTSAAGLAMGGLHPVVAIYSTFLNRAFDQVM
MDVALHRLPVTFVLDRAGITGSDGASHNGMWDLSILNVVPGMRVAAPRDASRLREELTEALAVDDGPTALRFPKGEVGED
IPAIERRDGVDILARPASGLHADVLLVAVGSFASTALATADRLGKQGIGVTVVDPRWVLPVPPHVVELAGQHRLVVTLED
SGVHGGAGSAVTAAMQDADVDIPSRDIGVPQQFLEHASRGQVLEELGLTDQHIARKITGWVAAMSREIGDSTVNPAAQQV
D
>Mature_641_residues
MLDDIRGPGDLQGLSKRELDLLADEIREFLIHKVAATGGHLGPNLGVVELSLALHRVFESPYDPIIFDTGHQAYVHKILT
GRAGDFDTLRQKDGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELTGQRRRHVVAVVGDGAMTGGMCWEALNNIA
AAEHRRIIIVVNDNGRSYAPTIGGLASHLAGLRLTPSYEKVLDESKKLLRGMPVVGPLAYALMHSLKVGVKDAVSPQVMF
TDLGLKYVGPVDGHDEHAVEDALRRARGYGGPVIVHVITRKGMGYAPAEDDEAEQMHSTGIIDPKTGRAIKASAPGWTSV
FSDALIDVASEHRNIVAITAAMPGPTGLSKFGERFPDRLFDVGIAEQHAVTSAAGLAMGGLHPVVAIYSTFLNRAFDQVM
MDVALHRLPVTFVLDRAGITGSDGASHNGMWDLSILNVVPGMRVAAPRDASRLREELTEALAVDDGPTALRFPKGEVGED
IPAIERRDGVDILARPASGLHADVLLVAVGSFASTALATADRLGKQGIGVTVVDPRWVLPVPPHVVELAGQHRLVVTLED
SGVHGGAGSAVTAAMQDADVDIPSRDIGVPQQFLEHASRGQVLEELGLTDQHIARKITGWVAAMSREIGDSTVNPAAQQV
D

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI225637463, Length=272, Percent_Identity=28.6764705882353, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI225637461, Length=272, Percent_Identity=28.6764705882353, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI225637459, Length=272, Percent_Identity=28.6764705882353, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI205277463, Length=248, Percent_Identity=29.4354838709677, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI4507521, Length=248, Percent_Identity=29.4354838709677, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI133778974, Length=636, Percent_Identity=23.2704402515723, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786622, Length=618, Percent_Identity=39.9676375404531, Blast_Score=445, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17539652, Length=290, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24666278, Length=607, Percent_Identity=25.0411861614498, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551847, Length=624, Percent_Identity=25.9615384615385, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45550715, Length=624, Percent_Identity=25.9615384615385, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24645119, Length=374, Percent_Identity=28.3422459893048, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MYCA9 (B1MCU7)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703722.1
- ProteinModelPortal:   B1MCU7
- SMR:   B1MCU7
- EnsemblBacteria:   EBMYCT00000004992
- GeneID:   5965497
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2990c
- GeneTree:   EBGT00050000016269
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   MABS561007:MAB_2990C-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68267; Mature: 68267

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDIRGPGDLQGLSKRELDLLADEIREFLIHKVAATGGHLGPNLGVVELSLALHRVFES
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
PYDPIIFDTGHQAYVHKILTGRAGDFDTLRQKDGLSGYPSRAESEHDWVESSHASTALSY
CCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELTGQRRRHVVAVVGDGAMTGGMCWEALNNIAAAEHRRIIIVVNDNGRSYAP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEECC
TIGGLASHLAGLRLTPSYEKVLDESKKLLRGMPVVGPLAYALMHSLKVGVKDAVSPQVMF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHCCCCEEEE
TDLGLKYVGPVDGHDEHAVEDALRRARGYGGPVIVHVITRKGMGYAPAEDDEAEQMHSTG
EECCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCC
IIDPKTGRAIKASAPGWTSVFSDALIDVASEHRNIVAITAAMPGPTGLSKFGERFPDRLF
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCHHHH
DVGIAEQHAVTSAAGLAMGGLHPVVAIYSTFLNRAFDQVMMDVALHRLPVTFVLDRAGIT
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GSDGASHNGMWDLSILNVVPGMRVAAPRDASRLREELTEALAVDDGPTALRFPKGEVGED
CCCCCCCCCEEEEEHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
IPAIERRDGVDILARPASGLHADVLLVAVGSFASTALATADRLGKQGIGVTVVDPRWVLP
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEECC
VPPHVVELAGQHRLVVTLEDSGVHGGAGSAVTAAMQDADVDIPSRDIGVPQQFLEHASRG
CCHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QVLEELGLTDQHIARKITGWVAAMSREIGDSTVNPAAQQVD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MLDDIRGPGDLQGLSKRELDLLADEIREFLIHKVAATGGHLGPNLGVVELSLALHRVFES
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
PYDPIIFDTGHQAYVHKILTGRAGDFDTLRQKDGLSGYPSRAESEHDWVESSHASTALSY
CCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELTGQRRRHVVAVVGDGAMTGGMCWEALNNIAAAEHRRIIIVVNDNGRSYAP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEECC
TIGGLASHLAGLRLTPSYEKVLDESKKLLRGMPVVGPLAYALMHSLKVGVKDAVSPQVMF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHCCCCEEEE
TDLGLKYVGPVDGHDEHAVEDALRRARGYGGPVIVHVITRKGMGYAPAEDDEAEQMHSTG
EECCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCC
IIDPKTGRAIKASAPGWTSVFSDALIDVASEHRNIVAITAAMPGPTGLSKFGERFPDRLF
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCHHHH
DVGIAEQHAVTSAAGLAMGGLHPVVAIYSTFLNRAFDQVMMDVALHRLPVTFVLDRAGIT
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GSDGASHNGMWDLSILNVVPGMRVAAPRDASRLREELTEALAVDDGPTALRFPKGEVGED
CCCCCCCCCEEEEEHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
IPAIERRDGVDILARPASGLHADVLLVAVGSFASTALATADRLGKQGIGVTVVDPRWVLP
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEECC
VPPHVVELAGQHRLVVTLEDSGVHGGAGSAVTAAMQDADVDIPSRDIGVPQQFLEHASRG
CCHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QVLEELGLTDQHIARKITGWVAAMSREIGDSTVNPAAQQVD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA