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The map label for this gene is kduD [C]

Identifier: 169630031

GI number: 169630031

Start: 3004557

End: 3005414

Strand: Reverse

Name: kduD [C]

Synonym: MAB_2948c

Alternate gene names: 169630031

Gene position: 3005414-3004557 (Counterclockwise)

Preceding gene: 169630032

Following gene: 169630030

Centisome position: 59.31

GC content: 61.42

Gene sequence:

>858_bases
TTGGAAGGACGGGTCGCCGTCATCACCGGTGCCGGTCGCGGTATCGGACGCGAACACGCGCTGTTGTTCGCCCGTGAGGG
AGCCAGTGTCGTCGTGAACGACCTGGGTGGCAGTAACGAGGGCGAGGGCGCCGACGCGGGGCCTGCGCACCAGGTTGTTG
ACGAAATTGTCTCTGCGGGAGGCAAAGCCGTCGCGAACACCGATAACATCGCTACCTGGGACGGCGCCGCAGGGCTGATT
GAGCAGGCCATCAGTGAGTTCGGGGGCTTGGATGTGGTGGTCAACAACGCCGGTATTCTGCGGGACGGATTCATTGCGGG
CATGGATGAATCCCAATGGGACAGCGTATTGACTGTGCATCTCAAGGGCCACTTTTCGGTGCTCCGGCACGCGGCAACGT
ACTGGAAGTCGCAGAGCAAGGACGGTAGTCAGCCGAATGCCGCCGTCGTCAACACCGCATCGGGATCGGGATTGACAGTT
CCCAATGCAGGGCAAGCGAACTATGGTGCGGCCAAGGCGGGCATTGCGGCGTTGACATTGGTCGCCGCCGAAGAATTGGA
GCGCTACGGCGTGCGGGTCAACGCCATAGCGCCGATCGCGCGCACCAGACTTACTCTGGCCACGCCTGGCATGGGTGCTC
TGATGGGTGAACCAGAAGACGGGGAGGTTGACCTATTCAGCCCGGCCAACATTTCGCCCCTAGTGGCGTACTTGGCATCC
GAGAAATGCCCGCTGAGCGGCAAGGTGTTCGCCGTGCAGGGTGGTGCGATCTCGGAACTGGCTGGCTGGCATGACGTGAA
GACCATTGAGACCGAAGATATCTGGCAGATCGATGACATCGCGGTGAGGTTGCCATGA

Upstream 100 bases:

>100_bases
CCGCGCGAACCGGAGAGAACGGCGAGGAGTTCGCCATCACAGACGGCCTGGCCGTCATCGCTGACTAGCCCAATCGCATA
GGAGTATTCAGGTGGGAGTT

Downstream 100 bases:

>100_bases
TCGAATGGTCGGAATCCGACGAACTCATCCGCGAAAGCGTTCGTGAGTTCATTGACAAAGAAGTCGAACCGCATCGCGAC
GGGCTGGAAAGCGGTGAACT

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MEGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNEGEGADAGPAHQVVDEIVSAGGKAVANTDNIATWDGAAGLI
EQAISEFGGLDVVVNNAGILRDGFIAGMDESQWDSVLTVHLKGHFSVLRHAATYWKSQSKDGSQPNAAVVNTASGSGLTV
PNAGQANYGAAKAGIAALTLVAAEELERYGVRVNAIAPIARTRLTLATPGMGALMGEPEDGEVDLFSPANISPLVAYLAS
EKCPLSGKVFAVQGGAISELAGWHDVKTIETEDIWQIDDIAVRLP

Sequences:

>Translated_285_residues
MEGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNEGEGADAGPAHQVVDEIVSAGGKAVANTDNIATWDGAAGLI
EQAISEFGGLDVVVNNAGILRDGFIAGMDESQWDSVLTVHLKGHFSVLRHAATYWKSQSKDGSQPNAAVVNTASGSGLTV
PNAGQANYGAAKAGIAALTLVAAEELERYGVRVNAIAPIARTRLTLATPGMGALMGEPEDGEVDLFSPANISPLVAYLAS
EKCPLSGKVFAVQGGAISELAGWHDVKTIETEDIWQIDDIAVRLP
>Mature_285_residues
MEGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNEGEGADAGPAHQVVDEIVSAGGKAVANTDNIATWDGAAGLI
EQAISEFGGLDVVVNNAGILRDGFIAGMDESQWDSVLTVHLKGHFSVLRHAATYWKSQSKDGSQPNAAVVNTASGSGLTV
PNAGQANYGAAKAGIAALTLVAAEELERYGVRVNAIAPIARTRLTLATPGMGALMGEPEDGEVDLFSPANISPLVAYLAS
EKCPLSGKVFAVQGGAISELAGWHDVKTIETEDIWQIDDIAVRLP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=260, Percent_Identity=41.9230769230769, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=35.6589147286822, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4758504, Length=206, Percent_Identity=32.0388349514563, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40254992, Length=195, Percent_Identity=31.2820512820513, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=31, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=27.1356783919598, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=30.3030303030303, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=31.5384615384615, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=30.1158301158301, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789378, Length=267, Percent_Identity=27.3408239700375, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790717, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786812, Length=198, Percent_Identity=29.7979797979798, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082160, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI2367175, Length=203, Percent_Identity=30.5418719211823, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=264, Percent_Identity=39.0151515151515, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI25147288, Length=266, Percent_Identity=33.8345864661654, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=26.7924528301887, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=296, Percent_Identity=28.7162162162162, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=29.7979797979798, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=262, Percent_Identity=30.1526717557252, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=285, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=275, Percent_Identity=28.7272727272727, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=202, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=232, Percent_Identity=30.1724137931034, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=247, Percent_Identity=26.7206477732794, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=298, Percent_Identity=25.1677852348993, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=203, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=281, Percent_Identity=27.4021352313167, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=198, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=197, Percent_Identity=26.9035532994924, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=298, Percent_Identity=26.1744966442953, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=29.5566502463054, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=194, Percent_Identity=27.319587628866, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=297, Percent_Identity=23.5690235690236, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=202, Percent_Identity=28.2178217821782, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=23.5955056179775, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=201, Percent_Identity=28.8557213930348, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=262, Percent_Identity=43.8931297709924, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI18859837, Length=286, Percent_Identity=41.958041958042, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24639444, Length=264, Percent_Identity=32.9545454545455, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357673, Length=199, Percent_Identity=30.1507537688442, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=198, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357041, Length=200, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737361, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355319, Length=209, Percent_Identity=28.2296650717703, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 29334; Mature: 29334

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNEGEGADAGPAHQVVDEIVSAG
CCCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC
GKAVANTDNIATWDGAAGLIEQAISEFGGLDVVVNNAGILRDGFIAGMDESQWDSVLTVH
CCEEECCCCCEECCCHHHHHHHHHHHHCCEEEEECCCCEEECCEEECCCCCCCCCEEEEE
LKGHFSVLRHAATYWKSQSKDGSQPNAAVVNTASGSGLTVPNAGQANYGAAKAGIAALTL
ECCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VAAEELERYGVRVNAIAPIARTRLTLATPGMGALMGEPEDGEVDLFSPANISPLVAYLAS
HHHHHHHHHCEEEEEECCHHHCEEEEECCCCHHCCCCCCCCCEEEECCCCHHHHHHHHHC
EKCPLSGKVFAVQGGAISELAGWHDVKTIETEDIWQIDDIAVRLP
CCCCCCCEEEEEECCCHHHHCCCCCCEEECCCCCEEECCEEEECC
>Mature Secondary Structure
MEGRVAVITGAGRGIGREHALLFAREGASVVVNDLGGSNEGEGADAGPAHQVVDEIVSAG
CCCCEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC
GKAVANTDNIATWDGAAGLIEQAISEFGGLDVVVNNAGILRDGFIAGMDESQWDSVLTVH
CCEEECCCCCEECCCHHHHHHHHHHHHCCEEEEECCCCEEECCEEECCCCCCCCCEEEEE
LKGHFSVLRHAATYWKSQSKDGSQPNAAVVNTASGSGLTVPNAGQANYGAAKAGIAALTL
ECCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VAAEELERYGVRVNAIAPIARTRLTLATPGMGALMGEPEDGEVDLFSPANISPLVAYLAS
HHHHHHHHHCEEEEEECCHHHCEEEEECCCCHHCCCCCCCCCEEEECCCCHHHHHHHHHC
EKCPLSGKVFAVQGGAISELAGWHDVKTIETEDIWQIDDIAVRLP
CCCCCCCEEEEEECCCHHHHCCCCCCEEECCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]