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The map label for this gene is uao [H]

Identifier: 169630012

GI number: 169630012

Start: 2984715

End: 2985623

Strand: Reverse

Name: uao [H]

Synonym: MAB_2929c

Alternate gene names: 169630012

Gene position: 2985623-2984715 (Counterclockwise)

Preceding gene: 169630013

Following gene: 169630010

Centisome position: 58.92

GC content: 60.95

Gene sequence:

>909_bases
ATGGGAATCGTTCTCGCAGGCAATCAATACGGCAAGGCCGAGAACCGGGTGGTCCGGATCTACCGGGACACCCCACGCCA
CGAGATCAAGGATCTCAACGTCGGCAGCGCGTTGCGCGGGGATTTCGCCGCGGCCTATACCGACGGCGACCAGCGCAAGG
TGCTGCCCACCGACAGCCAGAAGCAGACCATCTATGCCTACGCCAAGGAAAAAGGCATCGAGACCATCGAGCAGTACGGG
CTCGAGCTGGCGCGCCACTTCGTGGACGACTATGAGCCGGTGACGGGCGCTCGTATCGAGATCGATGAATATGCCTGGGA
AAGAGTGACGGTCGACGGACGCGAGCACGATCACACCTGGGTGCGCAAAGGTCAGGAGGTGCGCACGGCCGAGGTCACCG
TGGACGGTGTCGGGGCCCAGCAGCAGACCTGGGTGATCGGCGGGCTCAAGGATCTGGTCGTGCTCAAATCGACGGGCTCG
GAGTTCCATGATTTCCTCGAGGACAAGTACACGATCCTGCAGCCGACGACGGACCGGGTGATGGCCACCTCGCTGGTGGC
CAAGTGGCGCTTTGTGGGCACCGATATCGATTGGGATAATACATATTTCGGTGTAAAGTCGCTCATCCTCGAGCGGTTCG
CCACTGTGCACTCGCTGGCCCTGCAGCAGACGTTGTACGAGATTGGCAAGGCGATCCTGGAGTCTTATCCGTCAATCGCC
GAAGTGCGGCTCTCGGCACCCAACAAGCACCACTTCGTCTACGACCTATCACCTTTCGGGCTGGACAATCCCAACGAGGT
GTTCCATGCCGATGACCGTCCGTATGGGTTGATTCAGGCCGCGGTTACCCGTGATGACGCCCCCGATGCGGGGCCGGCCT
GGTCTCCGCATCTGTCCTGGTTGGTTTAG

Upstream 100 bases:

>100_bases
GCTTCCGGGCCGACGGAACCGCGGGGCACCTGCATGTGCCGCTGCTGCTGAGTCCGTACGCCTACTCGACCTACCGCGGC
AGCTGAGAAAGGAAGCACCC

Downstream 100 bases:

>100_bases
CGGTCGCTGTGGAGGTAGCCGGTGATATCGCGGCCACGTACCAGTACGGCGCTGATGGCGGGCTCCCGCAGACCCATCAG
CAGGCGAAACAGTGTCTGTT

Product: putative urate oxidase

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MGIVLAGNQYGKAENRVVRIYRDTPRHEIKDLNVGSALRGDFAAAYTDGDQRKVLPTDSQKQTIYAYAKEKGIETIEQYG
LELARHFVDDYEPVTGARIEIDEYAWERVTVDGREHDHTWVRKGQEVRTAEVTVDGVGAQQQTWVIGGLKDLVVLKSTGS
EFHDFLEDKYTILQPTTDRVMATSLVAKWRFVGTDIDWDNTYFGVKSLILERFATVHSLALQQTLYEIGKAILESYPSIA
EVRLSAPNKHHFVYDLSPFGLDNPNEVFHADDRPYGLIQAAVTRDDAPDAGPAWSPHLSWLV

Sequences:

>Translated_302_residues
MGIVLAGNQYGKAENRVVRIYRDTPRHEIKDLNVGSALRGDFAAAYTDGDQRKVLPTDSQKQTIYAYAKEKGIETIEQYG
LELARHFVDDYEPVTGARIEIDEYAWERVTVDGREHDHTWVRKGQEVRTAEVTVDGVGAQQQTWVIGGLKDLVVLKSTGS
EFHDFLEDKYTILQPTTDRVMATSLVAKWRFVGTDIDWDNTYFGVKSLILERFATVHSLALQQTLYEIGKAILESYPSIA
EVRLSAPNKHHFVYDLSPFGLDNPNEVFHADDRPYGLIQAAVTRDDAPDAGPAWSPHLSWLV
>Mature_301_residues
GIVLAGNQYGKAENRVVRIYRDTPRHEIKDLNVGSALRGDFAAAYTDGDQRKVLPTDSQKQTIYAYAKEKGIETIEQYGL
ELARHFVDDYEPVTGARIEIDEYAWERVTVDGREHDHTWVRKGQEVRTAEVTVDGVGAQQQTWVIGGLKDLVVLKSTGSE
FHDFLEDKYTILQPTTDRVMATSLVAKWRFVGTDIDWDNTYFGVKSLILERFATVHSLALQQTLYEIGKAILESYPSIAE
VRLSAPNKHHFVYDLSPFGLDNPNEVFHADDRPYGLIQAAVTRDDAPDAGPAWSPHLSWLV

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3648

COG function: function code Q; Uricase (urate oxidase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Drosophila melanogaster, GI17136576, Length=311, Percent_Identity=31.1897106109325, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 34083; Mature: 33952

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00366 URICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVLAGNQYGKAENRVVRIYRDTPRHEIKDLNVGSALRGDFAAAYTDGDQRKVLPTDSQ
CCEEEECCCCCCCCCEEEEEEECCCCHHHHCCCCCCHHCCCEEEEEECCCCCEECCCCCC
KQTIYAYAKEKGIETIEQYGLELARHFVDDYEPVTGARIEIDEYAWERVTVDGREHDHTW
CCEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCHH
VRKGQEVRTAEVTVDGVGAQQQTWVIGGLKDLVVLKSTGSEFHDFLEDKYTILQPTTDRV
HHCCCCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHCCEEEECCCHHHH
MATSLVAKWRFVGTDIDWDNTYFGVKSLILERFATVHSLALQQTLYEIGKAILESYPSIA
HHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
EVRLSAPNKHHFVYDLSPFGLDNPNEVFHADDRPYGLIQAAVTRDDAPDAGPAWSPHLSW
EEEECCCCCCEEEEECCCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
LV
CC
>Mature Secondary Structure 
GIVLAGNQYGKAENRVVRIYRDTPRHEIKDLNVGSALRGDFAAAYTDGDQRKVLPTDSQ
CEEEECCCCCCCCCEEEEEEECCCCHHHHCCCCCCHHCCCEEEEEECCCCCEECCCCCC
KQTIYAYAKEKGIETIEQYGLELARHFVDDYEPVTGARIEIDEYAWERVTVDGREHDHTW
CCEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCCHH
VRKGQEVRTAEVTVDGVGAQQQTWVIGGLKDLVVLKSTGSEFHDFLEDKYTILQPTTDRV
HHCCCCEEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHCCEEEECCCHHHH
MATSLVAKWRFVGTDIDWDNTYFGVKSLILERFATVHSLALQQTLYEIGKAILESYPSIA
HHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
EVRLSAPNKHHFVYDLSPFGLDNPNEVFHADDRPYGLIQAAVTRDDAPDAGPAWSPHLSW
EEEECCCCCCEEEEECCCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]