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The map label for this gene is fucA [C]

Identifier: 169629995

GI number: 169629995

Start: 2961292

End: 2962107

Strand: Reverse

Name: fucA [C]

Synonym: MAB_2912c

Alternate gene names: 169629995

Gene position: 2962107-2961292 (Counterclockwise)

Preceding gene: 169629998

Following gene: 169629994

Centisome position: 58.46

GC content: 62.62

Gene sequence:

>816_bases
ATGACCTCCGGAAATGTCGTGGCGGGCGAGGAGCTATCCGCATACATGGTCGGTTCCGCCGATGGCGTTCAGCTCGGTCC
CGCGGCGGCGGAAACGGTGACGCAGGAGCGTGAACGCAGATTGCGTGAGCTGGCGGCCGCGTTCCGGATTTTCGGGACTT
TCGGTTTCTCTGAAGGGGTGGCCGGACACATCACGGTCCGTGACCCGGAATTCCCCGACACGTTTTGGGTGAACCCTTTC
GGCATGAACTTCCGGCACATCACGGTGTCCGATCTGATTCAGGTCGATCACGACGGCAACGTGATCACCGGGAGCCGGCC
CGTGAACAGGGCAGCGTTCTGCATCCACTCCGAGGTCCATAAGGCGCGGCCTGACGTGATCGCCGCAGCGCACGCACACT
CGGTACATGGCAAGGCATTCTCGTCACTCGGTCAGCCGTTATTGCCCATCACGCAGGACGCCTGTGCCTTCTATCAAGAC
CATGCTGTGTACACCGATTACCGCGGGGTGGTCGGCGATCTGGAGGAGGGCAGGGCGATCGGATCGGCGCTCGGGCCGGC
CAAGGCGGTGATCCTGCAGAATCACGGATTGCTCACGGTGGGGCATTCGGTGGCGGAGGCCGCCTGGTGGTTTATCACAA
TGGAGCGCTCCTGCCAGGCTCAACTGCTTGCCATGGCGGCAGGCGAGCCCCGAACGATCGACCATGACACGGCCGTGTCG
GTCTACAACCAGATCGGGACTCCGGTCGCGGGGTGGTTTCAGTTCCAGCCGCTATGGGACGACGTGATCAGAACGGCTCC
AGAGGCCCTTCATTGA

Upstream 100 bases:

>100_bases
TATTCAGCGTCAATGCGCGTCGGGGCTTCTCTTGACGGGTGCACGTGGTGCGCGTAGGTTGTGGGCAGATAGATACGACT
ATGTATTGAAGGGTGAGTGC

Downstream 100 bases:

>100_bases
GCTCGCCGACACCCGGAATCGGGAATTGTCACCGATGAGCCGCGCCACCGACCAGTCGCAGCGGCTCAGCGACACGGCGC
TGACCGTTGACATGCATACC

Product: aldolase

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTSGNVVAGEELSAYMVGSADGVQLGPAAAETVTQERERRLRELAAAFRIFGTFGFSEGVAGHITVRDPEFPDTFWVNPF
GMNFRHITVSDLIQVDHDGNVITGSRPVNRAAFCIHSEVHKARPDVIAAAHAHSVHGKAFSSLGQPLLPITQDACAFYQD
HAVYTDYRGVVGDLEEGRAIGSALGPAKAVILQNHGLLTVGHSVAEAAWWFITMERSCQAQLLAMAAGEPRTIDHDTAVS
VYNQIGTPVAGWFQFQPLWDDVIRTAPEALH

Sequences:

>Translated_271_residues
MTSGNVVAGEELSAYMVGSADGVQLGPAAAETVTQERERRLRELAAAFRIFGTFGFSEGVAGHITVRDPEFPDTFWVNPF
GMNFRHITVSDLIQVDHDGNVITGSRPVNRAAFCIHSEVHKARPDVIAAAHAHSVHGKAFSSLGQPLLPITQDACAFYQD
HAVYTDYRGVVGDLEEGRAIGSALGPAKAVILQNHGLLTVGHSVAEAAWWFITMERSCQAQLLAMAAGEPRTIDHDTAVS
VYNQIGTPVAGWFQFQPLWDDVIRTAPEALH
>Mature_270_residues
TSGNVVAGEELSAYMVGSADGVQLGPAAAETVTQERERRLRELAAAFRIFGTFGFSEGVAGHITVRDPEFPDTFWVNPFG
MNFRHITVSDLIQVDHDGNVITGSRPVNRAAFCIHSEVHKARPDVIAAAHAHSVHGKAFSSLGQPLLPITQDACAFYQDH
AVYTDYRGVVGDLEEGRAIGSALGPAKAVILQNHGLLTVGHSVAEAAWWFITMERSCQAQLLAMAAGEPRTIDHDTAVSV
YNQIGTPVAGWFQFQPLWDDVIRTAPEALH

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=231, Percent_Identity=33.7662337662338, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI29826323, Length=231, Percent_Identity=33.7662337662338, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI29826321, Length=231, Percent_Identity=33.7662337662338, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI29826319, Length=231, Percent_Identity=33.7662337662338, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI89276787, Length=196, Percent_Identity=29.0816326530612, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI9943848, Length=188, Percent_Identity=28.7234042553192, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI9951927, Length=188, Percent_Identity=28.7234042553192, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI62912453, Length=188, Percent_Identity=28.7234042553192, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI297307160, Length=196, Percent_Identity=30.1020408163265, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI9257190, Length=196, Percent_Identity=30.1020408163265, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI297307158, Length=196, Percent_Identity=30.1020408163265, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI9257192, Length=196, Percent_Identity=30.1020408163265, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789164, Length=206, Percent_Identity=25.7281553398058, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533218, Length=213, Percent_Identity=31.924882629108, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115533216, Length=206, Percent_Identity=32.5242718446602, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989560, Length=196, Percent_Identity=30.6122448979592, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71989550, Length=196, Percent_Identity=30.6122448979592, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71989541, Length=196, Percent_Identity=30.6122448979592, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71989555, Length=196, Percent_Identity=30.6122448979592, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71989544, Length=196, Percent_Identity=30.6122448979592, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363755, Length=220, Percent_Identity=34.0909090909091, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI281363751, Length=220, Percent_Identity=34.0909090909091, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24655690, Length=220, Percent_Identity=34.0909090909091, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24655685, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281363763, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363757, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136738, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363761, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363759, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281363753, Length=220, Percent_Identity=34.0909090909091, Blast_Score=110, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 29314; Mature: 29183

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGNVVAGEELSAYMVGSADGVQLGPAAAETVTQERERRLRELAAAFRIFGTFGFSEGV
CCCCCEEECCCCCEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGHITVRDPEFPDTFWVNPFGMNFRHITVSDLIQVDHDGNVITGSRPVNRAAFCIHSEVH
EEEEEEECCCCCCCEEECCCCCCEEEEEHHHHEEECCCCCEEECCCCCCHHHHHHHHHHH
KARPDVIAAAHAHSVHGKAFSSLGQPLLPITQDACAFYQDHAVYTDYRGVVGDLEEGRAI
HCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHH
GSALGPAKAVILQNHGLLTVGHSVAEAAWWFITMERSCQAQLLAMAAGEPRTIDHDTAVS
HHHCCCCEEEEEECCCEEEECHHHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHH
VYNQIGTPVAGWFQFQPLWDDVIRTAPEALH
HHHHHCCCEEEEEEECCHHHHHHHCCHHHCC
>Mature Secondary Structure 
TSGNVVAGEELSAYMVGSADGVQLGPAAAETVTQERERRLRELAAAFRIFGTFGFSEGV
CCCCEEECCCCCEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGHITVRDPEFPDTFWVNPFGMNFRHITVSDLIQVDHDGNVITGSRPVNRAAFCIHSEVH
EEEEEEECCCCCCCEEECCCCCCEEEEEHHHHEEECCCCCEEECCCCCCHHHHHHHHHHH
KARPDVIAAAHAHSVHGKAFSSLGQPLLPITQDACAFYQDHAVYTDYRGVVGDLEEGRAI
HCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHH
GSALGPAKAVILQNHGLLTVGHSVAEAAWWFITMERSCQAQLLAMAAGEPRTIDHDTAVS
HHHCCCCEEEEEECCCEEEECHHHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHH
VYNQIGTPVAGWFQFQPLWDDVIRTAPEALH
HHHHHCCCEEEEEEECCHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]