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The map label for this gene is apt

Identifier: 169629961

GI number: 169629961

Start: 2931247

End: 2931780

Strand: Reverse

Name: apt

Synonym: MAB_2877c

Alternate gene names: 169629961

Gene position: 2931780-2931247 (Counterclockwise)

Preceding gene: 169629962

Following gene: 169629960

Centisome position: 57.86

GC content: 70.6

Gene sequence:

>534_bases
GTGACGGGCCCCGATGAGATAGCCGAACTCGTCGCGTCACTGACCCGTGAGGTCGCCGACTTTCCCGAGCCCGGGGTGCA
GTTCAAGGACCTGACGCCCCTGTTCGCGGATGCCGACGGATTGTCACGCGTCACCGACGCGCTGGCACAGGCGGCATCGG
GGGCCACGCTGATCGCGGGGATCGATGCCCGCGGCTTTCTGCTCGGGGCCGCGGTGGCGATCCGGCTCGGGGTCGGCGTG
TTGGCGGTGCGCAAGGCAGGGAAGTTGCCACCACCGGTGCATGCGCAGACCTACCAGCTCGAATACGGCACCGCGGCGCT
GGAGATCCCCGCAGACGGGGTGGAACTTGCGGGCCGCCGCGTGGCGATCGTCGACGATGTGCTGGCCACCGGCGGGACGC
TGGCGGCAACCGCGAGGCTGCTGACCACCGCGGGCGCCGACGTGATCAGTGCGGGCGTTGTCCTGGAACTCTCGGATCTG
GGCGGCCGCGCGGCCGTGGCGCCGCTGCCATTAACTGCGCTGCGCGCGATCTGA

Upstream 100 bases:

>100_bases
AGCCGCGTGTGCTGATCGCCCCGAAGTCGATGTACGCCGCCACCCCGAGCGTCACCCGGTGGGGTGCCGGCTGGAACATG
GATCGTTGGGTGCTGCCCAC

Downstream 100 bases:

>100_bases
GAGATAATCTATTGCGGTAGGAGGTGAACCGTGGCTGACGAGCACGTGCCCAGCGAGAATCAGGTCGCGGTCGAATCCCT
GCCTGCGTTGAGTGAGCCCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTGPDEIAELVASLTREVADFPEPGVQFKDLTPLFADADGLSRVTDALAQAASGATLIAGIDARGFLLGAAVAIRLGVGV
LAVRKAGKLPPPVHAQTYQLEYGTAALEIPADGVELAGRRVAIVDDVLATGGTLAATARLLTTAGADVISAGVVLELSDL
GGRAAVAPLPLTALRAI

Sequences:

>Translated_177_residues
MTGPDEIAELVASLTREVADFPEPGVQFKDLTPLFADADGLSRVTDALAQAASGATLIAGIDARGFLLGAAVAIRLGVGV
LAVRKAGKLPPPVHAQTYQLEYGTAALEIPADGVELAGRRVAIVDDVLATGGTLAATARLLTTAGADVISAGVVLELSDL
GGRAAVAPLPLTALRAI
>Mature_176_residues
TGPDEIAELVASLTREVADFPEPGVQFKDLTPLFADADGLSRVTDALAQAASGATLIAGIDARGFLLGAAVAIRLGVGVL
AVRKAGKLPPPVHAQTYQLEYGTAALEIPADGVELAGRRVAIVDDVLATGGTLAATARLLTTAGADVISAGVVLELSDLG
GRAAVAPLPLTALRAI

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=175, Percent_Identity=42.8571428571429, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI71773201, Length=132, Percent_Identity=44.6969696969697, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=40.5714285714286, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17509087, Length=180, Percent_Identity=39.4444444444444, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=36.5269461077844, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=36.4779874213836, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MYCA9 (B1MCI5)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703610.1
- ProteinModelPortal:   B1MCI5
- SMR:   B1MCI5
- EnsemblBacteria:   EBMYCT00000004612
- GeneID:   5965385
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2877c
- GeneTree:   EBGT00050000016328
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- BioCyc:   MABS561007:MAB_2877C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 17787; Mature: 17655

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPDEIAELVASLTREVADFPEPGVQFKDLTPLFADADGLSRVTDALAQAASGATLIAG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEE
IDARGFLLGAAVAIRLGVGVLAVRKAGKLPPPVHAQTYQLEYGTAALEIPADGVELAGRR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHCCCE
VAIVDDVLATGGTLAATARLLTTAGADVISAGVVLELSDLGGRAAVAPLPLTALRAI
EEEHHHHHHCCCHHHHHHHHHHHCCHHHHHCCEEEEECCCCCCEEECCCCHHHHHCC
>Mature Secondary Structure 
TGPDEIAELVASLTREVADFPEPGVQFKDLTPLFADADGLSRVTDALAQAASGATLIAG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEE
IDARGFLLGAAVAIRLGVGVLAVRKAGKLPPPVHAQTYQLEYGTAALEIPADGVELAGRR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCCHHHCCCE
VAIVDDVLATGGTLAATARLLTTAGADVISAGVVLELSDLGGRAAVAPLPLTALRAI
EEEHHHHHHCCCHHHHHHHHHHHCCHHHHHCCEEEEECCCCCCEEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA