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The map label for this gene is ppiB [H]

Identifier: 169629958

GI number: 169629958

Start: 2926954

End: 2927877

Strand: Direct

Name: ppiB [H]

Synonym: MAB_2874

Alternate gene names: 169629958

Gene position: 2926954-2927877 (Clockwise)

Preceding gene: 169629954

Following gene: 169629959

Centisome position: 57.76

GC content: 65.48

Gene sequence:

>924_bases
GTGCCGACCAACGAGCAGCGACGTCAGACTGCCAAGCGCAAGCTGGAGCGACAGCTGGAGAACCGTGCGGAGCGCGCCCG
CAAGCAGCGGATCTGGGCGATCAGCGGTGTCGCTGTGCTCGCTGTCGTCGTGGCGGTAGCCATCACCGCGTGGTTCGCCA
TCAGCAAGGGCGATAAGACCGACACGGCTCACGACACCGCGTCCACCACGCCGGTATCGACGGTTGACGCACCTCCGACG
TCGTCATTGCCGACGCCCGACGAACCACCTCTCGCCGGCCCGGCGCTGCCCAAGTTCGTACCGTCCGCCGAGGTGGGCGC
CAACTGTCAGTACCGACCGTCGGGCAAGGCTTCCAAGACCATCGAGAAGCAGATACCCCGGACAGGGAAGATCCCCACCG
ATCCCGCGACGCTCACCGCCAGCATGAAGACCAGCCAGGGCAACATCGGGCTGGTCTTGGATAACGCCAAAGCGCCCTGC
ACGGTGAACAGCTTCGCGAGCCTGGCGCAGGGCGGGTACTTCGACAACACCGTCTGCCACCGGATGACCAGCGGCGGCCT
GTCGGTACTGCAATGCGGTGACCCGACGGCCACCGGCTCGGGCGGCCCGGGATACGAGTTCGACAATGAATACCCGACCA
CCCAGTACAAGGCGGATGATCCGGCGGCGCAGCAGGCCGTCGTCTATCCCGCGGGCACGCTGGCCATGGCCAACGCGGGC
CCCGGAACCAACGGCAGCCAATTCTTCATGGTCTACAAGGATTCGAAGCTACCGCCGCAGTACACCGTCTTCGGGACGAT
CGACAAGACCGGGATGGACACCCTGGCCAAGATCGCCAAGAACGGCATCAAGCCCGGCGCACGTGGCGCGGGCGACGGAG
AGCCCGCACAAGAAGTGAAGATCATCGACCTGCAGCTCGACTGA

Upstream 100 bases:

>100_bases
GCGGCGGGTCCCGTGTCTTCTCTCAGGTGTGGCTGGCACACTCTCTGGCGACCTACATTCTTCGATGATTCTGCAATTGA
CGCCCTAGAAGGAGAGCCCG

Downstream 100 bases:

>100_bases
CATGATCTCTCGTCGCGCACTTCTTGTCGGTGGGGTATCGGCGGTCGGTGTGGTGGCTGCCGGTTGTTCGCGCAACGGCA
ACCGTCGGCCCGCGCCGGAC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPTNEQRRQTAKRKLERQLENRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKTDTAHDTASTTPVSTVDAPPT
SSLPTPDEPPLAGPALPKFVPSAEVGANCQYRPSGKASKTIEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPC
TVNSFASLAQGGYFDNTVCHRMTSGGLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKADDPAAQQAVVYPAGTLAMANAG
PGTNGSQFFMVYKDSKLPPQYTVFGTIDKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVKIIDLQLD

Sequences:

>Translated_307_residues
MPTNEQRRQTAKRKLERQLENRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKTDTAHDTASTTPVSTVDAPPT
SSLPTPDEPPLAGPALPKFVPSAEVGANCQYRPSGKASKTIEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPC
TVNSFASLAQGGYFDNTVCHRMTSGGLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKADDPAAQQAVVYPAGTLAMANAG
PGTNGSQFFMVYKDSKLPPQYTVFGTIDKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVKIIDLQLD
>Mature_306_residues
PTNEQRRQTAKRKLERQLENRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKTDTAHDTASTTPVSTVDAPPTS
SLPTPDEPPLAGPALPKFVPSAEVGANCQYRPSGKASKTIEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPCT
VNSFASLAQGGYFDNTVCHRMTSGGLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKADDPAAQQAVVYPAGTLAMANAGP
GTNGSQFFMVYKDSKLPPQYTVFGTIDKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVKIIDLQLD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=35.2941176470588, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI19557636, Length=147, Percent_Identity=34.0136054421769, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI64276486, Length=140, Percent_Identity=35, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7706339, Length=131, Percent_Identity=39.6946564885496, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=140, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=33.5820895522388, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=144, Percent_Identity=36.8055555555556, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=34.5070422535211, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922912, Length=167, Percent_Identity=29.940119760479, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32285; Mature: 32153

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNEQRRQTAKRKLERQLENRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DTAHDTASTTPVSTVDAPPTSSLPTPDEPPLAGPALPKFVPSAEVGANCQYRPSGKASKT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCCHHHH
IEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPCTVNSFASLAQGGYFDNTVCH
HHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCEEHHHHHHHHCCCCCCCHHHH
RMTSGGLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKADDPAAQQAVVYPAGTLAMANAG
HHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCEEEEECCC
PGTNGSQFFMVYKDSKLPPQYTVFGTIDKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVK
CCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
IIDLQLD
EEEEEEC
>Mature Secondary Structure 
PTNEQRRQTAKRKLERQLENRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DTAHDTASTTPVSTVDAPPTSSLPTPDEPPLAGPALPKFVPSAEVGANCQYRPSGKASKT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEECCCCCHHHH
IEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPCTVNSFASLAQGGYFDNTVCH
HHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCEEHHHHHHHHCCCCCCCHHHH
RMTSGGLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKADDPAAQQAVVYPAGTLAMANAG
HHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCEEEEECCC
PGTNGSQFFMVYKDSKLPPQYTVFGTIDKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVK
CCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
IIDLQLD
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]