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The map label for this gene is hisS [H]

Identifier: 169629956

GI number: 169629956

Start: 2924898

End: 2926172

Strand: Reverse

Name: hisS [H]

Synonym: MAB_2872c

Alternate gene names: 169629956

Gene position: 2926172-2924898 (Counterclockwise)

Preceding gene: 169629957

Following gene: 169629955

Centisome position: 57.75

GC content: 64.78

Gene sequence:

>1275_bases
GTGAGCGAGAAGACCTTCAGCGCGCCCAAGGGCATTCCGGACTATGTGCCGCCGGACTCGGCGCAGTTCTTGGCGGTCCG
CGATGGGCTACTGGAGCAGGCGCGTTTGGCCGGGTACGGCTACATCGAGCTGCCGGTGTTCGAGGACACCGGGCTGTTCG
CCCGCGGCGTCGGGGAGTCCACCGATGTCGTGAGCAAGGAGATGTACACCTTCGCGGACCGTGGTGATCGGTCGGTGACC
TTGCGGCCCGAGGGTACGGCGTCGGTGATGCGCGCGGTCATCGAGCACGGCCTAGACCGCGGCCAGCTTCCCGCGAAACT
TCGTTATGCCGGACCTTTTTTCCGATACGAGCGCCCGCAAGCAGGTCGCTATCGCCAGCTGCAGCAGGTGGGTGTGGAGG
CGATCGGTGTCGACGATCCGGCACTGGATGCCGAGGTGATCGCGATCGCCGATGCCGGATACCGTTCCCTGGGGCTAACA
GGCTTCCGTTTGGAGATCAGCTCGCTGGGTGACGCCTCCTGCCGTCCGCAGTACCGAGAGTTGTTGCAGGAATTCCTCTT
CGGCTTGGATCTGGACGAGGCGACGCGGGAACGGGCGCGCATCAACCCGATTCGGGTGCTCGATGACAAGCGGCCCGAGG
TGCGCGAGATGACGGCCAACGCGCCGCTCATGCTCGACCACCTTTCCGGGGAAGCCAAGGCGCATTTCGAGCAGGTACTC
AGTCATTTGGACGCGCTGGGCGTGCAGTACGTGGTGAATCCGCGTCTGGTGCGCGGCCTGGACTACTACACCAAGACCAC
ATTCGAATTCGTGCATGACGGATTGGGTGCGCAATCCGGTATCGGTGGCGGTGGCCGCTATGACGGACTGATGGCGCAGC
TGGGCGGACAGTCATTGTCGGGTATCGGCTTTGGGCTCGGTGTGGACAGAACCGTCCTGGCGCTGCGCGCCGAGGGAGTC
ACCGTGGGGGACAGCGGGCGCTGTGAGGTGTTCTGCGTTCCCCTTGGGCAGGACGCCAAATCGGTGCTCGTGAAGGTGGC
GGCACAGCTGCGCGGGGCGGGGATTCGCACCGATATCGCCTACGGAGACCGCGGACTCAAAGGCGCGATGCGCGGTGCGG
ACCGCTCGGGCGCCTCGATCGCGCTGGTAGCCGGGGACCGTGAAATCGGTGAGGGAAACATCGAGCTCAAGACGCTCGCC
GATGGCGTTCAGCAGCCGGTGCCTATCGGTTCGATTGTCGGGGAAGTAACGGCGCGGCTAGCATCGCGGATATGA

Upstream 100 bases:

>100_bases
TGCTTACGCGCGATGACTCCAGCGTTGTGCTGCCGGGACATGGCAATGCCACCAGCATCGGCGACGAGCGCCGCGCCAAC
CCATTCCTCGAGGGAATCCA

Downstream 100 bases:

>100_bases
CAGGTATGGGACGTATCACAGCAGCTCTGCTCGCCACCGCCAGTACCGCAACCCTGACGTTGGCGTTGGCGCCGGCCGCC
GAGGCGGCCCCGCACCAGGT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSEKTFSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPVFEDTGLFARGVGESTDVVSKEMYTFADRGDRSVT
LRPEGTASVMRAVIEHGLDRGQLPAKLRYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGYRSLGLT
GFRLEISSLGDASCRPQYRELLQEFLFGLDLDEATRERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVL
SHLDALGVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQSLSGIGFGLGVDRTVLALRAEGV
TVGDSGRCEVFCVPLGQDAKSVLVKVAAQLRGAGIRTDIAYGDRGLKGAMRGADRSGASIALVAGDREIGEGNIELKTLA
DGVQQPVPIGSIVGEVTARLASRI

Sequences:

>Translated_424_residues
MSEKTFSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPVFEDTGLFARGVGESTDVVSKEMYTFADRGDRSVT
LRPEGTASVMRAVIEHGLDRGQLPAKLRYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGYRSLGLT
GFRLEISSLGDASCRPQYRELLQEFLFGLDLDEATRERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVL
SHLDALGVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQSLSGIGFGLGVDRTVLALRAEGV
TVGDSGRCEVFCVPLGQDAKSVLVKVAAQLRGAGIRTDIAYGDRGLKGAMRGADRSGASIALVAGDREIGEGNIELKTLA
DGVQQPVPIGSIVGEVTARLASRI
>Mature_423_residues
SEKTFSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPVFEDTGLFARGVGESTDVVSKEMYTFADRGDRSVTL
RPEGTASVMRAVIEHGLDRGQLPAKLRYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGYRSLGLTG
FRLEISSLGDASCRPQYRELLQEFLFGLDLDEATRERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVLS
HLDALGVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQSLSGIGFGLGVDRTVLALRAEGVT
VGDSGRCEVFCVPLGQDAKSVLVKVAAQLRGAGIRTDIAYGDRGLKGAMRGADRSGASIALVAGDREIGEGNIELKTLAD
GVQQPVPIGSIVGEVTARLASRI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=471, Percent_Identity=22.7176220806794, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1788861, Length=424, Percent_Identity=41.2735849056604, Blast_Score=311, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI71993693, Length=463, Percent_Identity=23.9740820734341, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71993686, Length=463, Percent_Identity=23.9740820734341, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24643061, Length=471, Percent_Identity=23.7791932059448, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24643059, Length=487, Percent_Identity=22.9979466119097, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 45546; Mature: 45415

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTFSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPVFEDTGLFARGVGES
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCC
TDVVSKEMYTFADRGDRSVTLRPEGTASVMRAVIEHGLDRGQLPAKLRYAGPFFRYERPQ
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCC
AGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGYRSLGLTGFRLEISSLGDASCRPQYRE
CHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHHHCCEEEEEEECCCCCCCCCHHHHH
LLQEFLFGLDLDEATRERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVL
HHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHH
SHLDALGVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQSLS
HHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCC
GIGFGLGVDRTVLALRAEGVTVGDSGRCEVFCVPLGQDAKSVLVKVAAQLRGAGIRTDIA
CCEECCCCCCEEEEEEECCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEC
YGDRGLKGAMRGADRSGASIALVAGDREIGEGNIELKTLADGVQQPVPIGSIVGEVTARL
CCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHH
ASRI
HHCC
>Mature Secondary Structure 
SEKTFSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPVFEDTGLFARGVGES
CCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCC
TDVVSKEMYTFADRGDRSVTLRPEGTASVMRAVIEHGLDRGQLPAKLRYAGPFFRYERPQ
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCC
AGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGYRSLGLTGFRLEISSLGDASCRPQYRE
CHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHHHCCEEEEEEECCCCCCCCCHHHHH
LLQEFLFGLDLDEATRERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVL
HHHHHHHCCCCCHHHHHHHCCCCEEEECCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHH
SHLDALGVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQSLS
HHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCC
GIGFGLGVDRTVLALRAEGVTVGDSGRCEVFCVPLGQDAKSVLVKVAAQLRGAGIRTDIA
CCEECCCCCCEEEEEEECCEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEC
YGDRGLKGAMRGADRSGASIALVAGDREIGEGNIELKTLADGVQQPVPIGSIVGEVTARL
CCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHH
ASRI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA