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The map label for this gene is gmk [H]

Identifier: 169629907

GI number: 169629907

Start: 2873065

End: 2873565

Strand: Reverse

Name: gmk [H]

Synonym: MAB_2823c

Alternate gene names: 169629907

Gene position: 2873565-2873065 (Counterclockwise)

Preceding gene: 169629908

Following gene: 169629906

Centisome position: 56.71

GC content: 65.67

Gene sequence:

>501_bases
GTGCGTCGGCTACGCGATGAGGTCGACGGCCTGTTCTTCAGCGTTTCCGCGACCACCCGGGCCCCACGGCCGGGTGAGGT
GGACGGTGTCGACTATCACTTCGTCACCGCCGAGGAGTTTCAGCGGTTGATCGACACCGACGCGCTGCTGGAATGGGCGG
ACATCCACGGCGGATTACAACGCTCGGGAACCCCGGCCGCGCCCGTGCGTGAGGCCATGGAGGCGGGCCGCCCGACGCTC
ATCGAGGTCGATCTGGCCGGTGCCCGGGCGATCAAAGCCGCGCTCCCGCAGGCTCTCGCCGTCTTTCTGGCGCCACCGAG
CTGGGAGGCGCTGGTGGATCGGCTGACCGGCCGGGGCACCGAATCGGAGTCCGTGATTGCCCGGCGGCTGGAAACGGCCA
CGGTGGAAATGGCGGCCCAAACCGACTTTGATGTCGTCATCGTCAACGACCAGTTGGAAAATGCCTGCGCAAAGTTGGTA
TCGTTATTGGTCGGACGTTAA

Upstream 100 bases:

>100_bases
GAGCGGTTCGACTTTTCCTGATCTACTCCAGATGACAGCTTCGACGAGGGGCCGGGTAGTAGTCCTATCCGGCCCCTCCG
CCGTCGGTAAATCCACCGTT

Downstream 100 bases:

>100_bases
CCGGCAGCGCTGCACGAATTCTGCGCCAGCCATATTCAGCGCCATATACCTATCCAGGAGATTCTTTAGTGAGCACCTCC
CAGACCGACGTCATCGTCGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MRRLRDEVDGLFFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQRSGTPAAPVREAMEAGRPTL
IEVDLAGARAIKAALPQALAVFLAPPSWEALVDRLTGRGTESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLV
SLLVGR

Sequences:

>Translated_166_residues
MRRLRDEVDGLFFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQRSGTPAAPVREAMEAGRPTL
IEVDLAGARAIKAALPQALAVFLAPPSWEALVDRLTGRGTESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLV
SLLVGR
>Mature_166_residues
MRRLRDEVDGLFFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQRSGTPAAPVREAMEAGRPTL
IEVDLAGARAIKAALPQALAVFLAPPSWEALVDRLTGRGTESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLV
SLLVGR

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=163, Percent_Identity=41.7177914110429, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI4504221, Length=163, Percent_Identity=41.7177914110429, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI226874831, Length=163, Percent_Identity=41.7177914110429, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI38570142, Length=166, Percent_Identity=29.5180722891566, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1790080, Length=150, Percent_Identity=40, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193203132, Length=166, Percent_Identity=37.3493975903614, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=166, Percent_Identity=37.3493975903614, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=159, Percent_Identity=42.1383647798742, Blast_Score=126, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356141, Length=168, Percent_Identity=34.5238095238095, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 17999; Mature: 17999

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRDEVDGLFFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQ
CCHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCC
RSGTPAAPVREAMEAGRPTLIEVDLAGARAIKAALPQALAVFLAPPSWEALVDRLTGRGT
CCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
ESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLVSLLVGR
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRLRDEVDGLFFSVSATTRAPRPGEVDGVDYHFVTAEEFQRLIDTDALLEWADIHGGLQ
CCHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCC
RSGTPAAPVREAMEAGRPTLIEVDLAGARAIKAALPQALAVFLAPPSWEALVDRLTGRGT
CCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
ESESVIARRLETATVEMAAQTDFDVVIVNDQLENACAKLVSLLVGR
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA