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The map label for this gene is coaBC [H]

Identifier: 169629905

GI number: 169629905

Start: 2871386

End: 2872633

Strand: Reverse

Name: coaBC [H]

Synonym: MAB_2821c

Alternate gene names: 169629905

Gene position: 2872633-2871386 (Counterclockwise)

Preceding gene: 169629906

Following gene: 169629904

Centisome position: 56.69

GC content: 66.35

Gene sequence:

>1248_bases
ATGTCCCGGATCATCGTCGGAGTGGGTGGAGGAATCGCCGCCTACAAGGCCTGCACCGTGGTGCGCCAGCTCGCCGAGGC
CGGGCACAGCGTCCGGGTCGTTCCCACCGAGTCGGCCCTGCAGTTCGTGGGAGCCGCGACCTTTGAGGCGCTCTCCGGTG
AGCCGGCCCGTACCGGGGTGTTCGACGATGTTCCCGAGGTTCCGCACGTGCGGCTCGGACAGGATGCCGACCTGGTAGTG
GTCGCTCCCGCCACCGCGGACCTGCTGTCGCGTGCCGCCACCGGCCGGGCGGATGACCTGCTGACCGCGACCCTGCTCAC
CGCCACGTGTCCAGTGCTGTTCGCCCCCGCGATGCATACGGAGATGTGGCTGCATCCGGCAACCCAGCAGAATGTCGCGA
CCCTGCGGAGCCGTGGCGCGGTTGTCCTGGAGCCCGCCTCTGGCCGCCTGACGGGGGCGGACACCGGCCCGGGCCGTCTT
CCCGAGGCCGAAGAAATCACCACCCTGGCCCAATTATTGCTGGCACGACCCGACGCGCTGCCGCACGATCTGGCCGGTGT
GCGGGTCCTGGTCACCGCCGGCGGCACTCGTGAACCCCTGGACCCGGTGCGCTTTATCGGAAACCGCAGTTCCGGTAAGC
AGGGATACGCCATCGCCCGGGTCGCCGCTCAGCGTGGTGCCGAAGTCACGCTCATCGCGGGTCATACCGTCGGCTTACCG
GATCCCGCTGGCGTCGAGGTGGTGCATATCAGCTCCGCCGCGCAATTGCAGGACGCTGTCACCAAACACGCTCCTGCGGC
CGAAGCGCTGATCATGGCGGCAGCGGTGGCAGATTTCCGGCCGGCCCACGTTGCGACCAGCAAGATCAAAAAGAGCCACG
GGGCCGCCGGTGAGAATGACGCGCCCATTGAGTTGCTGCGCAACGCCGATGTGCTGGCCGGTGTGGTTCGTGCGCGTGCA
GACGGGCAGCTGCCCAAGATGCGGGCAATCGTCGGGTTTGCCGCGGAAACGGGCGACGCAAACGGCGATGTGCTCTTTCA
CGCCCGCGCCAAGTTGAAGCGCAAGGGCTGTGATTTGTTGGTAGTCAACGCTGTTGGCGAGGGACGGGCCTTCGAGGTGG
ACAGCAATGACGGGTGGTTGCTCTCGGCGCAGAGTGGTGGTGACATCACCGAAGTTGTCCTTGAACACGGCACCAAAGTT
CTGATGGCAAGCCGTATTGTGGATGCCGTTGCCGGGCTTTGTCAGTGA

Upstream 100 bases:

>100_bases
GCGCGAGATCCACGGCGACCTGCTCGAGCACACCGAAGGCGAGTAAGAAGCTCTGCGATGAGCCGCTTGCGCGAAGAGCA
TCAAGGCTAGGGCGACGTCC

Downstream 100 bases:

>100_bases
AGCTGACAACCGGGCATGGCCTCGATCTTGGTTCGTCGGCCATAATGATTAGGACATGTAACGATCTGAAAGGGGCTGCG
CTGTGAGCTCAGCTGGACGG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVV
VAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRL
PEAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP
DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARA
DGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKV
LMASRIVDAVAGLCQ

Sequences:

>Translated_415_residues
MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVV
VAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRL
PEAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP
DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARA
DGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKV
LMASRIVDAVAGLCQ
>Mature_414_residues
SRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGVFDDVPEVPHVRLGQDADLVVV
APATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHTEMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLP
EAEEITTLAQLLLARPDALPHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLPD
PAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGENDAPIELLRNADVLAGVVRARAD
GQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLLVVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVL
MASRIVDAVAGLCQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=165, Percent_Identity=34.5454545454545, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082301, Length=378, Percent_Identity=41.5343915343915, Blast_Score=231, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42826; Mature: 42695

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGV
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCC
FDDVPEVPHVRLGQDADLVVVAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHT
CCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH
EMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLPEAEEITTLAQLLLARPDAL
HHEECCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP
CCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGEND
CCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
APIELLRNADVLAGVVRARADGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLL
CCHHHHHCCHHHHHHHHHCCCCCCCHHHHHEEEHHCCCCCCCCEEEEEHHHHHHCCCCEE
VVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVLMASRIVDAVAGLCQ
EEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRIIVGVGGGIAAYKACTVVRQLAEAGHSVRVVPTESALQFVGAATFEALSGEPARTGV
CEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCC
FDDVPEVPHVRLGQDADLVVVAPATADLLSRAATGRADDLLTATLLTATCPVLFAPAMHT
CCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH
EMWLHPATQQNVATLRSRGAVVLEPASGRLTGADTGPGRLPEAEEITTLAQLLLARPDAL
HHEECCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PHDLAGVRVLVTAGGTREPLDPVRFIGNRSSGKQGYAIARVAAQRGAEVTLIAGHTVGLP
CCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
DPAGVEVVHISSAAQLQDAVTKHAPAAEALIMAAAVADFRPAHVATSKIKKSHGAAGEND
CCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
APIELLRNADVLAGVVRARADGQLPKMRAIVGFAAETGDANGDVLFHARAKLKRKGCDLL
CCHHHHHCCHHHHHHHHHCCCCCCCHHHHHEEEHHCCCCCCCCEEEEEHHHHHHCCCCEE
VVNAVGEGRAFEVDSNDGWLLSAQSGGDITEVVLEHGTKVLMASRIVDAVAGLCQ
EEEECCCCEEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]