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The map label for this gene is tkt [H]

Identifier: 169629843

GI number: 169629843

Start: 2805984

End: 2808113

Strand: Direct

Name: tkt [H]

Synonym: MAB_2759

Alternate gene names: 169629843

Gene position: 2805984-2808113 (Clockwise)

Preceding gene: 169629841

Following gene: 169629844

Centisome position: 55.38

GC content: 66.24

Gene sequence:

>2130_bases
GTGACCGCGATCTCACGTGAACTGGCGGAAGTCCCGACCGATATTCCAACCCTGACCCGGGTCGACCACCCGGATGACTG
GACCGAGCTGGACTCACGCGCGGTGGACACCGTGCGGGTGTTGGCCGCTGACGCGGTGCAGAAGGTTGGCAATGGCCACC
CTGGCACTGCGATGAGCCTGGCGCCCGTGGCGTACACGCTTTTTCAGCGTCAGTTGCGCCACGATCCCAGCGACACCACC
TGGATCGGCCGCGACCGGTTCGTGCTGTCCTGCGGGCACAGCAGCCTGACTTTGTACTTGCAGCTCTACTTAGGCGGGTT
TGGCCTGGAGCTCTCCGATATCGAAGCGCTACGCACCTGGGGCTCCCTGACTCCCGGGCACCCCGAGTACCACCACACCA
AGGGTGTGGAGATCACCACCGGGCCGCTGGGCCAGGGCTTGGCCTCCGCGGTCGGCATGGCGATGGCCTCCCGATACGAG
CGTGGCTTGTTCGATCCGGACGCCGCCCCCGGTACCAGCCCGTTCGATCACTTCATCTACGTCATCGCCTCCGACGGGGA
TATCGAAGAGGGCGTGACTTCGGAGGCCTCGTCGTTGGCGGGCACTCAGCAGCTCGGAAACCTCATCGTCATCTGGGATG
ACAATGAGATCTCCATTGAGCACGACACCAAGATCGCACTCTCGGAGGACACCCCCGCCCGCTACGAGGCGTACGGCTGG
CATGTACAGACCGTCGTCAGTGGTGAGAACGTCACCGGCCTTGAAGAAGCACTGGCCAACGCCCGTGCGGTCACCGACCG
CCCGTCGTTCATCGCGCTGCGCACGATCATCGGTTACCCCGCTCCCACCAAGATGAACACCGGCGGTGTGCACGGCTCGG
CCCTGGGCGCTGACGAGGTGGCCGCCACCAAAAAGATTTTGGGCTTCGACCCGGATAAATCCTTCGAGGTGGCCCCCGAG
GTCATCGCGCACACGCGCGAACTGGTGACGCGCGGTAAGCAGGCGCATGCCGAGTGGGACAAGAGCTTTGAGGCCTGGGC
GGCCCGTGAGCCCGAGCGCAAGGCGCTGCTGGACCGCCTCCAGGCGCGTGCGTTGCCGCAGGGCTGGGACGCCGGGCTGC
CGTCCTGGGAGCCCGGTTCCAAGGCGGTGGCCACCCGCGCCGCCTCCGGCGACACGCTTTCGGCGCTCGGGGCCAAGCTG
CCCGAGCTGTGGGGCGGCTCGGCGGATCTGGCGGGCAGCAACAACACCACCATCAAGGGCGCCGATTCCTTTGGCCCGAC
CTCCATCGCGACGTCCGACTGGAATGCCCAACCCTATGGCCGCACACTGCATTTCGGCATCCGCGAGCACGCGATGGGTT
CCATCTTGTCCGGCATCGTGCTGCACGGACCCACCCGCGCGTACGGCGGAACGTTCCTGCAGTTCGCCGACTACATGCGC
CCCGCGGTGCGTCTGGCCGCGCTGATGAACATCGACCCGATCTACGTCTGGACACATGACTCGATCGGTCTGGGCGAGGA
CGGGCCCACCCACCAGCCGGTGGAACACCTGGCCGCCCTACGCGCCATCCCCAACCTCTCGGTGGTGCGCCCCGGCGACG
CCAACGAAACCGCGTACGCCTGGGCGACCGTCCTGGAGCGCCAATCCAGCACCGGCCCCGTCGGTTTGGCACTCACCCGC
CAGGGTGTGCCGATCCTGGAAGGCACCAGCCGCGAAGGCGTGGCCAAGGGCGGCTACGTGCTGGAGGCAGCCAGTGACAA
TCCGGCGGACGCTCCCGATGTGATCCTCATCGGCACGGGCTCGGAACTGCAGCTCGCCGTCGAGGCCAAGAAGATTCTTG
CCGCCAAGGGAATTGCGGCCTCCGTGGTGTCGTTGCCCTGTGTGGAATGGTTCGAATCCCAGCCCCAGGAATATCGCGAC
AGCGTGCTGCCGCCGTCCGTACGCGCGCGTGTGGTGGTGGAAGCCGGCATCGCGCAGGGCTGGTACAAGTTCGTCGGCGA
TGCGGGGCAGATCGTCTCCCTGGAGCATTTCGGAGCTTCGGCCGACGACAAGACGTTGTTCCGCGAGTTCGGCTTCACCC
CTGACGCAGTGGCCGCAGCGGCCGAAAGGTCAATCGCAGCAGCTCAATAA

Upstream 100 bases:

>100_bases
GTGAACACCGGTTGTCTGTCACTGGACTATCACATTGCTCGCACGGCGTGACCCGGCCTTGAGGCAGCGGCATGAAATCG
TCAGCACTACGATGGGGCCC

Downstream 100 bases:

>100_bases
CCCCGAATCAGGAAGGGATGAATCCCATGAGCACATCTGATCAGAACGCTAATCTCGCCGAACTGAGCGAGGCCGGAGTC
GCTGTCTGGCTCGATGATCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MTAISRELAEVPTDIPTLTRVDHPDDWTELDSRAVDTVRVLAADAVQKVGNGHPGTAMSLAPVAYTLFQRQLRHDPSDTT
WIGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIEALRTWGSLTPGHPEYHHTKGVEITTGPLGQGLASAVGMAMASRYE
RGLFDPDAAPGTSPFDHFIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVIWDDNEISIEHDTKIALSEDTPARYEAYGW
HVQTVVSGENVTGLEEALANARAVTDRPSFIALRTIIGYPAPTKMNTGGVHGSALGADEVAATKKILGFDPDKSFEVAPE
VIAHTRELVTRGKQAHAEWDKSFEAWAAREPERKALLDRLQARALPQGWDAGLPSWEPGSKAVATRAASGDTLSALGAKL
PELWGGSADLAGSNNTTIKGADSFGPTSIATSDWNAQPYGRTLHFGIREHAMGSILSGIVLHGPTRAYGGTFLQFADYMR
PAVRLAALMNIDPIYVWTHDSIGLGEDGPTHQPVEHLAALRAIPNLSVVRPGDANETAYAWATVLERQSSTGPVGLALTR
QGVPILEGTSREGVAKGGYVLEAASDNPADAPDVILIGTGSELQLAVEAKKILAAKGIAASVVSLPCVEWFESQPQEYRD
SVLPPSVRARVVVEAGIAQGWYKFVGDAGQIVSLEHFGASADDKTLFREFGFTPDAVAAAAERSIAAAQ

Sequences:

>Translated_709_residues
MTAISRELAEVPTDIPTLTRVDHPDDWTELDSRAVDTVRVLAADAVQKVGNGHPGTAMSLAPVAYTLFQRQLRHDPSDTT
WIGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIEALRTWGSLTPGHPEYHHTKGVEITTGPLGQGLASAVGMAMASRYE
RGLFDPDAAPGTSPFDHFIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVIWDDNEISIEHDTKIALSEDTPARYEAYGW
HVQTVVSGENVTGLEEALANARAVTDRPSFIALRTIIGYPAPTKMNTGGVHGSALGADEVAATKKILGFDPDKSFEVAPE
VIAHTRELVTRGKQAHAEWDKSFEAWAAREPERKALLDRLQARALPQGWDAGLPSWEPGSKAVATRAASGDTLSALGAKL
PELWGGSADLAGSNNTTIKGADSFGPTSIATSDWNAQPYGRTLHFGIREHAMGSILSGIVLHGPTRAYGGTFLQFADYMR
PAVRLAALMNIDPIYVWTHDSIGLGEDGPTHQPVEHLAALRAIPNLSVVRPGDANETAYAWATVLERQSSTGPVGLALTR
QGVPILEGTSREGVAKGGYVLEAASDNPADAPDVILIGTGSELQLAVEAKKILAAKGIAASVVSLPCVEWFESQPQEYRD
SVLPPSVRARVVVEAGIAQGWYKFVGDAGQIVSLEHFGASADDKTLFREFGFTPDAVAAAAERSIAAAQ
>Mature_708_residues
TAISRELAEVPTDIPTLTRVDHPDDWTELDSRAVDTVRVLAADAVQKVGNGHPGTAMSLAPVAYTLFQRQLRHDPSDTTW
IGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIEALRTWGSLTPGHPEYHHTKGVEITTGPLGQGLASAVGMAMASRYER
GLFDPDAAPGTSPFDHFIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVIWDDNEISIEHDTKIALSEDTPARYEAYGWH
VQTVVSGENVTGLEEALANARAVTDRPSFIALRTIIGYPAPTKMNTGGVHGSALGADEVAATKKILGFDPDKSFEVAPEV
IAHTRELVTRGKQAHAEWDKSFEAWAAREPERKALLDRLQARALPQGWDAGLPSWEPGSKAVATRAASGDTLSALGAKLP
ELWGGSADLAGSNNTTIKGADSFGPTSIATSDWNAQPYGRTLHFGIREHAMGSILSGIVLHGPTRAYGGTFLQFADYMRP
AVRLAALMNIDPIYVWTHDSIGLGEDGPTHQPVEHLAALRAIPNLSVVRPGDANETAYAWATVLERQSSTGPVGLALTRQ
GVPILEGTSREGVAKGGYVLEAASDNPADAPDVILIGTGSELQLAVEAKKILAAKGIAASVVSLPCVEWFESQPQEYRDS
VLPPSVRARVVVEAGIAQGWYKFVGDAGQIVSLEHFGASADDKTLFREFGFTPDAVAAAAERSIAAAQ

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=710, Percent_Identity=25.6338028169014, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4507521, Length=710, Percent_Identity=25.6338028169014, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI133778974, Length=606, Percent_Identity=23.9273927392739, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI225637459, Length=604, Percent_Identity=22.3509933774834, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI225637461, Length=506, Percent_Identity=23.5177865612648, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637463, Length=506, Percent_Identity=23.7154150197628, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI48994911, Length=673, Percent_Identity=43.8335809806835, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI1788808, Length=676, Percent_Identity=43.6390532544379, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17539652, Length=595, Percent_Identity=25.8823529411765, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325331, Length=683, Percent_Identity=45.8272327964861, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319593, Length=683, Percent_Identity=44.5095168374817, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45551847, Length=596, Percent_Identity=25.503355704698, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45550715, Length=596, Percent_Identity=25.503355704698, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24645119, Length=568, Percent_Identity=25.3521126760563, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666278, Length=607, Percent_Identity=25.3706754530478, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75558; Mature: 75427

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAISRELAEVPTDIPTLTRVDHPDDWTELDSRAVDTVRVLAADAVQKVGNGHPGTAMSL
CCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
APVAYTLFQRQLRHDPSDTTWIGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIEALRTW
HHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
GSLTPGHPEYHHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAAPGTSPFDHFIY
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
VIASDGDIEEGVTSEASSLAGTQQLGNLIVIWDDNEISIEHDTKIALSEDTPARYEAYGW
EEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEECCCCCCCEEEECE
HVQTVVSGENVTGLEEALANARAVTDRPSFIALRTIIGYPAPTKMNTGGVHGSALGADEV
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCHHHH
AATKKILGFDPDKSFEVAPEVIAHTRELVTRGKQAHAEWDKSFEAWAAREPERKALLDRL
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QARALPQGWDAGLPSWEPGSKAVATRAASGDTLSALGAKLPELWGGSADLAGSNNTTIKG
HHHCCCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
ADSFGPTSIATSDWNAQPYGRTLHFGIREHAMGSILSGIVLHGPTRAYGGTFLQFADYMR
CCCCCCCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
PAVRLAALMNIDPIYVWTHDSIGLGEDGPTHQPVEHLAALRAIPNLSVVRPGDANETAYA
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHH
WATVLERQSSTGPVGLALTRQGVPILEGTSREGVAKGGYVLEAASDNPADAPDVILIGTG
HHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEECC
SELQLAVEAKKILAAKGIAASVVSLPCVEWFESQPQEYRDSVLPPSVRARVVVEAGIAQG
CCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHEEEEEEHHHHHH
WYKFVGDAGQIVSLEHFGASADDKTLFREFGFTPDAVAAAAERSIAAAQ
HHHHHCCCCCEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAISRELAEVPTDIPTLTRVDHPDDWTELDSRAVDTVRVLAADAVQKVGNGHPGTAMSL
CCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
APVAYTLFQRQLRHDPSDTTWIGRDRFVLSCGHSSLTLYLQLYLGGFGLELSDIEALRTW
HHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
GSLTPGHPEYHHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAAPGTSPFDHFIY
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
VIASDGDIEEGVTSEASSLAGTQQLGNLIVIWDDNEISIEHDTKIALSEDTPARYEAYGW
EEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEECCCCCCCEEEECE
HVQTVVSGENVTGLEEALANARAVTDRPSFIALRTIIGYPAPTKMNTGGVHGSALGADEV
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCHHHH
AATKKILGFDPDKSFEVAPEVIAHTRELVTRGKQAHAEWDKSFEAWAAREPERKALLDRL
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QARALPQGWDAGLPSWEPGSKAVATRAASGDTLSALGAKLPELWGGSADLAGSNNTTIKG
HHHCCCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
ADSFGPTSIATSDWNAQPYGRTLHFGIREHAMGSILSGIVLHGPTRAYGGTFLQFADYMR
CCCCCCCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
PAVRLAALMNIDPIYVWTHDSIGLGEDGPTHQPVEHLAALRAIPNLSVVRPGDANETAYA
HHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHH
WATVLERQSSTGPVGLALTRQGVPILEGTSREGVAKGGYVLEAASDNPADAPDVILIGTG
HHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEECC
SELQLAVEAKKILAAKGIAASVVSLPCVEWFESQPQEYRDSVLPPSVRARVVVEAGIAQG
CCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHEEEEEEHHHHHH
WYKFVGDAGQIVSLEHFGASADDKTLFREFGFTPDAVAAAAERSIAAAQ
HHHHHCCCCCEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]