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The map label for this gene is csd [H]

Identifier: 169629830

GI number: 169629830

Start: 2792446

End: 2793690

Strand: Reverse

Name: csd [H]

Synonym: MAB_2746c

Alternate gene names: 169629830

Gene position: 2793690-2792446 (Counterclockwise)

Preceding gene: 169629831

Following gene: 169629829

Centisome position: 55.13

GC content: 64.9

Gene sequence:

>1245_bases
GTGACGGCCACTGTGCCGCTCGATATCACCGCGATCAGGAATGATTTCCCGATCCTGAGTCGGACGGTGCGCGGTGGTAA
ACCGCTGGCGTATCTGGATTCCGGGGCCACCTCGCAGCGCCCGGTGCAAGTGCTCGACGCCGAACGCCGTTTCCTCACCG
AGCGCAATGCGGCCGTGCACCGCGGCGCACATCAGCTGGCGGAGGAAGCGACGGACGCCTACGAGGGCGCGCGCAATGCG
ATTGCCCGGTTCGTGGGTGTCGACGACGGCGAGATCGTGTTCACCAAGAACGCGACCGAATCGCTGAACCTGGTGGCCTA
CACCCTCGGTGACAACAGGTTCGATCGTGCGGTGGGACCGGGCGATGAGATCGTCGTCACCGAACTCGAGCATCACGCGA
ATCTGGTTCCGTGGCAGGAACTCTGCCGCCGCACCGGCGCCACCCTGAGGTGGTTTGGCGTGACTGACGATGGCCGTATT
GATGTCGACTCGCTGGAACTCACCGAAGCGGTCAAGGTTGTCGCATTCACCCATCAGTCGAATGTGACGGGTGCCGTCGC
GCCAGTGGCAGAACTGGTGCGACGTGCGAAGGCCGTTGGCGCCCTGGTGGTTCTCGATGCCTGCCAGTCCGTCCCGCACA
TGTCGGTGAACTTCCGGGAGCTGGGGGTGGACTACGCGGCGTTCTCCGGACACAAGATGCTTGGCCCCTCCGGGGTGGGG
GTGTTGTATGGCCGGCGTGCGCTGCTGGAGGCTATGCCCCCGTTCATCACCGGCGGCTCCATGATCGAGACGGTGACCAT
GGAGGTCAGCACCTATGCACCGCCGCCTCAACGATTTGAGGCAGGTGTGCCGATGACCTCCCAGGTGGTGGGCCTGGGCG
CGGCCGTCGATTATCTCAATGCGGTGGGTATGGAAGCCGTTGCCGCACACGAACATCAGTTGGTGTCCGCGGCGCTCGCC
GGGCTTGCCGGCATCGAGGGCGTCCGCATCATCGGCCCCACGGACAACCTCGATCGCGGTGGGGCGGTCTCCTTCGTGGT
GGACGGTATTCACGCGCACGACCTAGGACAGGTGCTCGACGACGAGGGCGTCGCGGTGCGGGTCGGCCATCATTGTGCGT
GGCCGCTGCACCGTCGATTCGGCATAGCGGCCAGCGCCCGCGCATCTTTCGCGGTGTACAACACCCTGGACGAGGTCGAT
CGGCTGACCGCCGGTGTTCGCCGCGCACAGGAGTTCTTTTCATAA

Upstream 100 bases:

>100_bases
TCGTCGGCGGCCGCATCGTCGAGTCCGGTGGCCCCGAGCTGGCCGACGAGCTGGAGGAGAACGGCTATGTGCGCTTCACC
CAAGCGGTGGGAGCCTGACC

Downstream 100 bases:

>100_bases
TGCGTCTGGAGCAGATGTACCAGGAAGTCATCCTGGATCACTACAAGCATCCGCACCATCGCGGGCTGCGTGAGCCGTTC
GCGGCCGAGGTACACCATGT

Product: cysteine desulfurase/aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTATVPLDITAIRNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVHRGAHQLAEEATDAYEGARNA
IARFVGVDDGEIVFTKNATESLNLVAYTLGDNRFDRAVGPGDEIVVTELEHHANLVPWQELCRRTGATLRWFGVTDDGRI
DVDSLELTEAVKVVAFTHQSNVTGAVAPVAELVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVG
VLYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAAVDYLNAVGMEAVAAHEHQLVSAALA
GLAGIEGVRIIGPTDNLDRGGAVSFVVDGIHAHDLGQVLDDEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNTLDEVD
RLTAGVRRAQEFFS

Sequences:

>Translated_414_residues
MTATVPLDITAIRNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVHRGAHQLAEEATDAYEGARNA
IARFVGVDDGEIVFTKNATESLNLVAYTLGDNRFDRAVGPGDEIVVTELEHHANLVPWQELCRRTGATLRWFGVTDDGRI
DVDSLELTEAVKVVAFTHQSNVTGAVAPVAELVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVG
VLYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAAVDYLNAVGMEAVAAHEHQLVSAALA
GLAGIEGVRIIGPTDNLDRGGAVSFVVDGIHAHDLGQVLDDEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNTLDEVD
RLTAGVRRAQEFFS
>Mature_413_residues
TATVPLDITAIRNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVHRGAHQLAEEATDAYEGARNAI
ARFVGVDDGEIVFTKNATESLNLVAYTLGDNRFDRAVGPGDEIVVTELEHHANLVPWQELCRRTGATLRWFGVTDDGRID
VDSLELTEAVKVVAFTHQSNVTGAVAPVAELVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVGV
LYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAAVDYLNAVGMEAVAAHEHQLVSAALAG
LAGIEGVRIIGPTDNLDRGGAVSFVVDGIHAHDLGQVLDDEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNTLDEVDR
LTAGVRRAQEFFS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=300, Percent_Identity=29.3333333333333, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156713448, Length=310, Percent_Identity=26.1290322580645, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787970, Length=411, Percent_Identity=43.30900243309, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=37.0466321243523, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=28.428927680798, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=234, Percent_Identity=26.9230769230769, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193211090, Length=370, Percent_Identity=25.9459459459459, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=404, Percent_Identity=26.2376237623762, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129463, Length=236, Percent_Identity=31.7796610169492, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44265; Mature: 44133

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATVPLDITAIRNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVH
CCEEEEEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
RGAHQLAEEATDAYEGARNAIARFVGVDDGEIVFTKNATESLNLVAYTLGDNRFDRAVGP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCC
GDEIVVTELEHHANLVPWQELCRRTGATLRWFGVTDDGRIDVDSLELTEAVKVVAFTHQS
CCCEEEEEHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHEEEEEEECC
NVTGAVAPVAELVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEECCCCCCCCCCCCH
VLYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAAVDYLN
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHH
AVGMEAVAAHEHQLVSAALAGLAGIEGVRIIGPTDNLDRGGAVSFVVDGIHAHDLGQVLD
HHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHC
DEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNTLDEVDRLTAGVRRAQEFFS
CCCCEEEECCCCCCHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TATVPLDITAIRNDFPILSRTVRGGKPLAYLDSGATSQRPVQVLDAERRFLTERNAAVH
CEEEEEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
RGAHQLAEEATDAYEGARNAIARFVGVDDGEIVFTKNATESLNLVAYTLGDNRFDRAVGP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCC
GDEIVVTELEHHANLVPWQELCRRTGATLRWFGVTDDGRIDVDSLELTEAVKVVAFTHQS
CCCEEEEEHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHEEEEEEECC
NVTGAVAPVAELVRRAKAVGALVVLDACQSVPHMSVNFRELGVDYAAFSGHKMLGPSGVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEECCCCCCCCCCCCH
VLYGRRALLEAMPPFITGGSMIETVTMEVSTYAPPPQRFEAGVPMTSQVVGLGAAVDYLN
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHH
AVGMEAVAAHEHQLVSAALAGLAGIEGVRIIGPTDNLDRGGAVSFVVDGIHAHDLGQVLD
HHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHC
DEGVAVRVGHHCAWPLHRRFGIAASARASFAVYNTLDEVDRLTAGVRRAQEFFS
CCCCEEEECCCCCCHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]