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The map label for this gene is echA12 [H]

Identifier: 169629821

GI number: 169629821

Start: 2786257

End: 2787066

Strand: Reverse

Name: echA12 [H]

Synonym: MAB_2737c

Alternate gene names: 169629821

Gene position: 2787066-2786257 (Counterclockwise)

Preceding gene: 169629822

Following gene: 169629820

Centisome position: 55.0

GC content: 64.2

Gene sequence:

>810_bases
ATGAGTTTCGTCCTGGTGGACCGTCCGCGTCCGGAAATTGCCCTGGTCACCCTGAACCGGCCCGAGCGGATGAATGCCAT
GGCGTTCGACGTGATGCTGCCTTTCAAGCAGATGCTCGTCGATATCAGCCACGACAATGACGTGCGCGCCGTCGTGATCA
CGGGCGCCGGTAAGGGCTTTTGTTCGGGCGCCGACCAGAAGTCGGCCGGCCCCATTCCGCATATCGGCGGACTGACCCAG
CCCACCATCGCGTTGCGTTCCATGGAACTGCTCGACGAGGTGATCCTCACGCTGCGCCGCATGCATCAGCCGGTGATCGC
GGCCATCAACGGTGCGGCCATCGGCGGCGGACTATGCCTGGCGCTGGCGTGCGACGTCCGGGTGGCCTCGCAGGACGCGT
ACTTCCGGGCGGCCGGAATCAACAACGGGTTGACCGCCAGCGAACTGGGTCTGAGCTATCTGCTGCCCCGCGCCATCGGC
ACCTCGCGCGCCTCTGACATCATGTTGACCGGCCGCGACGTCGACGCCGACGAGGCCGAACGCATCGGATTGGTATCCCG
GAAGGTGGCGTCCGAGTCGCTGCTGGAAGAGTGTTACGCGATCGGGGAACGCATCGCCGGGTTCTCCCGTCCGGGAATCG
AGTTGACCAAGCGCACGATTTGGAGTGGGCTGGACGCCGCTAGCCTGGAAAGTCATATGCACCAAGAGGGCCTGGGCCAG
CTATATGTCCGGCTACTCACCGACAACTTCGAAGAAGCCACCGCCGCGCGCAAGGAGAAGCGGCCGGCGGAATTCAGAGA
CAAGCGCTGA

Upstream 100 bases:

>100_bases
AGAATCCGGTCCGGGCCGGCTGACCGCTCCGTATGGCATGGCCGCACGTGCGGCGGCACAGCGATTTGGTGCAGCCCGGC
GCGGTCGGTTATATGGATTC

Downstream 100 bases:

>100_bases
GACGTGCCCGGCACGCACCCAGCATCCAAGGAGTAAGTAGTGATTACCGCGACGGACCTCGAGGTCCGCGCCGGCGCCCG
CACGCTCGTCTACGCGCCGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSFVLVDRPRPEIALVTLNRPERMNAMAFDVMLPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQ
PTIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVASQDAYFRAAGINNGLTASELGLSYLLPRAIG
TSRASDIMLTGRDVDADEAERIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESHMHQEGLGQ
LYVRLLTDNFEEATAARKEKRPAEFRDKR

Sequences:

>Translated_269_residues
MSFVLVDRPRPEIALVTLNRPERMNAMAFDVMLPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQ
PTIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVASQDAYFRAAGINNGLTASELGLSYLLPRAIG
TSRASDIMLTGRDVDADEAERIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESHMHQEGLGQ
LYVRLLTDNFEEATAARKEKRPAEFRDKR
>Mature_268_residues
SFVLVDRPRPEIALVTLNRPERMNAMAFDVMLPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQP
TIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVASQDAYFRAAGINNGLTASELGLSYLLPRAIGT
SRASDIMLTGRDVDADEAERIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESHMHQEGLGQL
YVRLLTDNFEEATAARKEKRPAEFRDKR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=256, Percent_Identity=32.421875, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI70995211, Length=268, Percent_Identity=32.8358208955224, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI31542718, Length=269, Percent_Identity=30.1115241635688, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI68989263, Length=195, Percent_Identity=33.8461538461538, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI20127408, Length=188, Percent_Identity=28.1914893617021, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI116235487, Length=165, Percent_Identity=28.4848484848485, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI213417737, Length=179, Percent_Identity=24.5810055865922, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI157694516, Length=179, Percent_Identity=24.5810055865922, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=269, Percent_Identity=29.368029739777, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788597, Length=186, Percent_Identity=33.8709677419355, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=275, Percent_Identity=29.4545454545455, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI221142681, Length=200, Percent_Identity=29.5, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=211, Percent_Identity=31.7535545023697, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790281, Length=196, Percent_Identity=27.5510204081633, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=282, Percent_Identity=31.9148936170213, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=32.2834645669291, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=30.5019305019305, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17534483, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=218, Percent_Identity=30.7339449541284, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=241, Percent_Identity=28.6307053941909, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=215, Percent_Identity=27.4418604651163, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=32.6923076923077, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=32.6923076923077, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19920382, Length=270, Percent_Identity=30.3703703703704, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24653139, Length=278, Percent_Identity=30.2158273381295, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19922422, Length=258, Percent_Identity=25.968992248062, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357171, Length=220, Percent_Identity=30.9090909090909, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24654903, Length=177, Percent_Identity=29.9435028248588, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650670, Length=205, Percent_Identity=31.219512195122, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921000, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583079, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29159; Mature: 29028

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVLVDRPRPEIALVTLNRPERMNAMAFDVMLPFKQMLVDISHDNDVRAVVITGAGKGF
CCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCCCC
CSGADQKSAGPIPHIGGLTQPTIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHE
ALACDVRVASQDAYFRAAGINNGLTASELGLSYLLPRAIGTSRASDIMLTGRDVDADEAE
EHHHCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
RIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESHMHQEGLGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LYVRLLTDNFEEATAARKEKRPAEFRDKR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SFVLVDRPRPEIALVTLNRPERMNAMAFDVMLPFKQMLVDISHDNDVRAVVITGAGKGF
CEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCCCC
CSGADQKSAGPIPHIGGLTQPTIALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHE
ALACDVRVASQDAYFRAAGINNGLTASELGLSYLLPRAIGTSRASDIMLTGRDVDADEAE
EHHHCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
RIGLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESHMHQEGLGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LYVRLLTDNFEEATAARKEKRPAEFRDKR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]