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The map label for this gene is tetR [H]

Identifier: 169629770

GI number: 169629770

Start: 2727227

End: 2727901

Strand: Direct

Name: tetR [H]

Synonym: MAB_2685

Alternate gene names: 169629770

Gene position: 2727227-2727901 (Clockwise)

Preceding gene: 169629766

Following gene: 169629774

Centisome position: 53.82

GC content: 66.81

Gene sequence:

>675_bases
ATGGCCATCACTGAGCCAAACAAGGGGCGCACAGCCCCGCCGATGAGCCGCTTACGCGAAGAGCGTCGAGCGCTGAACCG
ACACGACCTGGTACGCCGGGCGACCGCGATTCTCGACGACTACGGAATCGCGGACCTCACGATGCGGCGGCTCGCTCGCG
AGCTCGATATCGCACCCAGCGCGCTGTATTGGCATTTCGCGAACAAACAGCAGCTGCTCGGCGCGGTGGCCGATCACGTG
CTGGCACCTTTGGCCGAGTCCGACCGCCGGGATGCGCCCTGGCAGGAACGCATCGACTTTTTGTGCTCGGCTCTTCGCGA
TGCACTGCTCTCCCATAAGGACGGCGCCGAACTGGTGTCGGCCAGCTTCGCGTCCGGACAGACCGCACACATGATCACCG
TGCTGGATCGCCTGGCCGAGGCCGCGGCGACCGCGGGCCTGGGCGCAGTTCCCGCCGCCCTCGCCGCCCGTAGCATCGTC
TATTACGTGCTCGGCTACGTCGCCGATGAGCAGTCGCGGCTGCAATGGGACTCCGCGGGCGCCCTTGAGAACGGTCAATC
GTTCCTCGCGGACGGCGCGGGGTTCGCCGATCCCAGCGCGCAATTCGGTTTCGGCGCGCGCCTTCTGGTGGACGGGATCG
GCCAGTTGGCCCGTCAGTCCAGTCCGATCGGTTAG

Upstream 100 bases:

>100_bases
GGCGTCCGTCGCGGCTGTCAGCTCGGCTGTCTCAGTCACGCAGGGCTCCTCACTAGGTACAAACCTGATACACAATCCTG
AACGGTGTTCAGGTTAGAGT

Downstream 100 bases:

>100_bases
GCGACCAGGCCGGCGACCCACTGCGGTTCGAAAAGTTCGATACTCAGCTCCGCGAATACCGGGGGCATGAGCCGCGCCGC
ACCCTCGGGAATCACCGCGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MAITEPNKGRTAPPMSRLREERRALNRHDLVRRATAILDDYGIADLTMRRLARELDIAPSALYWHFANKQQLLGAVADHV
LAPLAESDRRDAPWQERIDFLCSALRDALLSHKDGAELVSASFASGQTAHMITVLDRLAEAAATAGLGAVPAALAARSIV
YYVLGYVADEQSRLQWDSAGALENGQSFLADGAGFADPSAQFGFGARLLVDGIGQLARQSSPIG

Sequences:

>Translated_224_residues
MAITEPNKGRTAPPMSRLREERRALNRHDLVRRATAILDDYGIADLTMRRLARELDIAPSALYWHFANKQQLLGAVADHV
LAPLAESDRRDAPWQERIDFLCSALRDALLSHKDGAELVSASFASGQTAHMITVLDRLAEAAATAGLGAVPAALAARSIV
YYVLGYVADEQSRLQWDSAGALENGQSFLADGAGFADPSAQFGFGARLLVDGIGQLARQSSPIG
>Mature_223_residues
AITEPNKGRTAPPMSRLREERRALNRHDLVRRATAILDDYGIADLTMRRLARELDIAPSALYWHFANKQQLLGAVADHVL
APLAESDRRDAPWQERIDFLCSALRDALLSHKDGAELVSASFASGQTAHMITVLDRLAEAAATAGLGAVPAALAARSIVY
YVLGYVADEQSRLQWDSAGALENGQSFLADGAGFADPSAQFGFGARLLVDGIGQLARQSSPIG

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24109; Mature: 23978

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITEPNKGRTAPPMSRLREERRALNRHDLVRRATAILDDYGIADLTMRRLARELDIAPS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
ALYWHFANKQQLLGAVADHVLAPLAESDRRDAPWQERIDFLCSALRDALLSHKDGAELVS
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
ASFASGQTAHMITVLDRLAEAAATAGLGAVPAALAARSIVYYVLGYVADEQSRLQWDSAG
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCC
ALENGQSFLADGAGFADPSAQFGFGARLLVDGIGQLARQSSPIG
CHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AITEPNKGRTAPPMSRLREERRALNRHDLVRRATAILDDYGIADLTMRRLARELDIAPS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
ALYWHFANKQQLLGAVADHVLAPLAESDRRDAPWQERIDFLCSALRDALLSHKDGAELVS
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
ASFASGQTAHMITVLDRLAEAAATAGLGAVPAALAARSIVYYVLGYVADEQSRLQWDSAG
HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCC
ALENGQSFLADGAGFADPSAQFGFGARLLVDGIGQLARQSSPIG
CHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3241623 [H]