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The map label for this gene is mprA [H]

Identifier: 169629667

GI number: 169629667

Start: 2626160

End: 2626909

Strand: Direct

Name: mprA [H]

Synonym: MAB_2581

Alternate gene names: 169629667

Gene position: 2626160-2626909 (Clockwise)

Preceding gene: 169629665

Following gene: 169629668

Centisome position: 51.83

GC content: 59.33

Gene sequence:

>750_bases
ATGTCAGATGCAGCGTCGGTGAGCTCCGAGAAAGCACGCTCCTCATTACGTCGGCCTGACGGAAGCCCCGTCAGGGTATT
AGTTGTCGACGACGAACGTTCGTTGGCCGAGCTGATTTCGATGGCGCTGCGCTACGAGGGCTGGGAAATTCACGTCGCCG
GCGATGGCATGAGTGCCGTCAAACTGGCGCGCCAGGTACATCCCGACATTGTGGTGCTGGATGTGATGTTGCCTGACGTC
AGCGGCCTGGAAGTGCTGCGGCAGCTTCGTGACCTTTACCCGGGATTGCCGCTGTTGCTGCTCACGGCGAAGGACTCACT
GGAAGATCGGATAGCGGGCCTGACCGCTGGCGGCGACGACTACGTGACTAAGCCGTTCAGCCTGGAGGAAGTGGTGTTGC
GCCTACGGGCATTACTGCGTCGGACGGGAATCGCGGGCGACAGCGGCGACGCACGATTGATCGTGGGCGACCTTGTCCTG
GACGAGGACAGCCACGAGGTGACCCGCGACGGCGAGCTGATCAATCTGACGGCCACCGAGTTTGAGCTCCTGCGCTTCAT
GATGCGCAACAACAAACGTGTACTGAGCAAGCATCAGATCCTTGACCGGGTGTGGAGTTATGACTTCGGTGGACGTTCCA
ATGTGGTCGAGCTCTACATCTCGTACTTGCGGAAGAAGATAGACACAGGGCGCGAGCCCATGATTCATACGTTGCGTGGC
GCCGGATATGTTCTCAAACCGGCGCATTAG

Upstream 100 bases:

>100_bases
GAGTCAACGGATAGCAGTTTGCTCTTTGCCCGTCCACACAGCGCACATAGGCGACTCACAGCTGACGCATAGACTGATCG
TTGAGGATCGGTAGGTGGCC

Downstream 100 bases:

>100_bases
CAGAGCAATTCGCCGTGCTCTGCCTAGGCCGTGGTCGCTGCGGGCGCGCCTATTGGCGGTCCAGGCCGCGTTGCTGGCTT
TTGTCTGCGTGGGTATTGGC

Product: putative two component transcriptional regulatory protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWEIHVAGDGMSAVKLARQVHPDIVVLDVMLPDV
SGLEVLRQLRDLYPGLPLLLLTAKDSLEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGIAGDSGDARLIVGDLVL
DEDSHEVTRDGELINLTATEFELLRFMMRNNKRVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREPMIHTLRG
AGYVLKPAH

Sequences:

>Translated_249_residues
MSDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWEIHVAGDGMSAVKLARQVHPDIVVLDVMLPDV
SGLEVLRQLRDLYPGLPLLLLTAKDSLEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGIAGDSGDARLIVGDLVL
DEDSHEVTRDGELINLTATEFELLRFMMRNNKRVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREPMIHTLRG
AGYVLKPAH
>Mature_248_residues
SDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWEIHVAGDGMSAVKLARQVHPDIVVLDVMLPDVS
GLEVLRQLRDLYPGLPLLLLTAKDSLEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGIAGDSGDARLIVGDLVLD
EDSHEVTRDGELINLTATEFELLRFMMRNNKRVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREPMIHTLRGA
GYVLKPAH

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.2857142857143, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.9369369369369, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=38.6666666666667, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.1681415929204, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=35.1351351351351, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=34.5132743362832, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.9307359307359, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=30.7017543859649, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=30.5676855895196, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.7610619469027, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=36.697247706422, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=30.2521008403361, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=107, Percent_Identity=29.9065420560748, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27745; Mature: 27614

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWEIHVAGDGMSAV
CCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
KLARQVHPDIVVLDVMLPDVSGLEVLRQLRDLYPGLPLLLLTAKDSLEDRIAGLTAGGDD
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCC
YVTKPFSLEEVVLRLRALLRRTGIAGDSGDARLIVGDLVLDEDSHEVTRDGELINLTATE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEHHH
FELLRFMMRNNKRVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREPMIHTLRG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCC
AGYVLKPAH
CCEEECCCC
>Mature Secondary Structure 
SDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWEIHVAGDGMSAV
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
KLARQVHPDIVVLDVMLPDVSGLEVLRQLRDLYPGLPLLLLTAKDSLEDRIAGLTAGGDD
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCC
YVTKPFSLEEVVLRLRALLRRTGIAGDSGDARLIVGDLVLDEDSHEVTRDGELINLTATE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEHHH
FELLRFMMRNNKRVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREPMIHTLRG
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCC
AGYVLKPAH
CCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA