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The map label for this gene is cobC [C]

Identifier: 169628993

GI number: 169628993

Start: 1902019

End: 1903122

Strand: Direct

Name: cobC [C]

Synonym: MAB_1905

Alternate gene names: 169628993

Gene position: 1902019-1903122 (Clockwise)

Preceding gene: 169628992

Following gene: 169628994

Centisome position: 37.54

GC content: 64.58

Gene sequence:

>1104_bases
GTGAAGGTTCTGGTCGAAGCCGACGGTGGTTCACGCGGCAACCCGGGTCTGGCCGGATACGGCGCGGTGGTGTTTTCTCC
CGATCACCAGACGGTGTTGGGGGAGGCCTGTGATGCCATCGGCCATGCGACCAACAATGTCGCCGAGTACCGGGGCCTGA
TAGCGGGATTGGCCGAGGCGGCACGCCTGGGGGCCACCGAGGTGAGCGTCTCGATGGACTCCAAACTTGTCGTCGAGCAG
ATGTCCGGCAGGTGGAAGGTCAAACATCCTGACCTGATCACGCTGTACCAGCAGGCCGTCACTGCCGCGATGCAGTTCGA
GTCCGTTGACTACACGTGGATTCCGCGAGAACGCAACAAGCATGCCGATCGGCTGGCCAACGAGGCGATGGATCGTGCCA
GTGGCATCGAGCCCAAAAAGCCCAAGGAAATCGCAGAAATCAAGGAGACGAAGCCTGCCGATACTGCGCCGGGCTGGACC
GGGGCGCGGGGGAAGCCCACCCGGATGTTGTTGTTGCGCCATGGGCAGACCGAACTCTCGGTGCAGCGCCGGTACTCGGG
CCGCGGAAACCCCGAGCTAACCGAACTGGGGCGCGAGCAGGCGGCGCGGGCCGCGCGCTATCTGGCCAGCCGGGGCGGCA
TCGCGGCAGTGATCAGCTCGCCGCTGAGCCGTGCCAAGGAGACTGCCGCGGCAGCGGCCGGTGCGCTGGGAGTGCCGCTG
ACGGTCGACGACGATCTGATCGAGACCGACTTCGGTAAGTGGGAAGGCCTGACCTTCTCCGAGGCATCCGAGCGCGACCC
CGAGCTGCATCGCCAATGGCTCAGCGACACCTCGATAACTCCGCCGGAAGGGGAGAGCTTCGATACGGTGCACCACCGAG
TGCGGCGTGCGCGCAACCGGATCATCGCTGAATACGGTGGCGCAACCGTTTTGGTGGTCTCGCACGTCACGCCCATCAAG
ACACTGCTGCGGCTGGCGCTCGATGCCGGCCCCAGCGTGCTGTACCGGCTGCATCTCGATCTGGCCTCGCTGAGTATTGC
CGAGTTCTATTCGGACGGTCCGGCATCGGTGCGACTCGTCAATGAAACGTCCTACCTGACTTAG

Upstream 100 bases:

>100_bases
GCCGCATCGAGCTGGACCGCGGCGAACTGGCCCGGATCTCGGCGGCCGACGCCGACGAGGTGCTGCGGTGCCCCGAGTGC
AGCGCGATTCTGGTGCGCCC

Downstream 100 bases:

>100_bases
GCTGTCGCCATGGTTTCTCGTGATCACGGCGATCCTGGCGATGCGCCCACCATCGCTCCACCCCTGGCAGATGTCGCCAA
CCCGGCCCGGCCGTCGGCGG

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEYRGLIAGLAEAARLGATEVSVSMDSKLVVEQ
MSGRWKVKHPDLITLYQQAVTAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKETKPADTAPGWT
GARGKPTRMLLLRHGQTELSVQRRYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPL
TVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNRIIAEYGGATVLVVSHVTPIK
TLLRLALDAGPSVLYRLHLDLASLSIAEFYSDGPASVRLVNETSYLT

Sequences:

>Translated_367_residues
MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEYRGLIAGLAEAARLGATEVSVSMDSKLVVEQ
MSGRWKVKHPDLITLYQQAVTAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKETKPADTAPGWT
GARGKPTRMLLLRHGQTELSVQRRYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPL
TVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNRIIAEYGGATVLVVSHVTPIK
TLLRLALDAGPSVLYRLHLDLASLSIAEFYSDGPASVRLVNETSYLT
>Mature_367_residues
MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEYRGLIAGLAEAARLGATEVSVSMDSKLVVEQ
MSGRWKVKHPDLITLYQQAVTAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKETKPADTAPGWT
GARGKPTRMLLLRHGQTELSVQRRYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPL
TVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNRIIAEYGGATVLVVSHVTPIK
TLLRLALDAGPSVLYRLHLDLASLSIAEFYSDGPASVRLVNETSYLT

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790856, Length=183, Percent_Identity=30.6010928961749, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 39743; Mature: 39743

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEYRGLIAGLAEA
CEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAVTAAMQFESVDYTWIPRERNK
HHCCCCEEEECCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCH
HADRLANEAMDRASGIEPKKPKEIAEIKETKPADTAPGWTGARGKPTRMLLLRHGQTELS
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
VQRRYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
TVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNR
EECCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
IIAEYGGATVLVVSHVTPIKTLLRLALDAGPSVLYRLHLDLASLSIAEFYSDGPASVRLV
HHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEE
NETSYLT
CCCCCCC
>Mature Secondary Structure
MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEYRGLIAGLAEA
CEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAVTAAMQFESVDYTWIPRERNK
HHCCCCEEEECCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCH
HADRLANEAMDRASGIEPKKPKEIAEIKETKPADTAPGWTGARGKPTRMLLLRHGQTELS
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
VQRRYSGRGNPELTELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
TVDDDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNR
EECCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
IIAEYGGATVLVVSHVTPIKTLLRLALDAGPSVLYRLHLDLASLSIAEFYSDGPASVRLV
HHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEE
NETSYLT
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]