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The map label for this gene is maeB [C]

Identifier: 169628475

GI number: 169628475

Start: 1379762

End: 1380925

Strand: Direct

Name: maeB [C]

Synonym: MAB_1384

Alternate gene names: 169628475

Gene position: 1379762-1380925 (Clockwise)

Preceding gene: 169628474

Following gene: 169628476

Centisome position: 27.23

GC content: 64.86

Gene sequence:

>1164_bases
GTGACTGCATCCGACGTTGTTGTGACAGATGAAGAGATTTTTGAGGCACATATCGACGGGAAGCTGTCGGTAGAGCTCAA
GTCGCCGCTGGATACCCAGCGCGCGCTGTCGATTGCCTACACCCCGGGTGTCGCACAGGTATCGCGGGCCATCGCCGCCG
ATGCCAGTCTGGCCAAGAAGTACACCTGGGCGCACCGCCTGGTCGCTGTGGTCAGTGACGGTAGTGCCGTGCTGGGGCTG
GGCGATATCGGCCCGTCGGCATCGCTGCCCGTCATGGAGGGCAAGAGCGCCCTGTTCAAGACATTCGCCGGCCTCAACTC
CATCCCGATCGTGCTTGACACCAAGGACCCCGATGAGATCGTCGAGACGCTGATCCGTCTGCGCCCCACCTTCGGTGCGG
TCAACCTGGAGGACATCTCGGCGCCGCGCTGTTTCGAGATCGAGCGACGCGTTATCGAGGCGCTCGACTGTCCCGTCATG
CACGACGACCAACACGGCACCGCCATCGTGGTGCTCGCCGCCCTTATGGGTGCTTCCCGGGTGTTGGGACGCGATCAGCA
GTCCCTCAAGGTGGTCATCTCCGGCGCGGGCGCGGCCGGCGTGGCGTGCGCCAACATCCTGCTGGCCGACGGCATCAACG
ATGTGACGGTGCTGGATTCGAAGGGGATCGTGCACACCAGCCGCGATGATCTCAACGAGTTCAAGGCCGACCTCGCCGCG
CGGACCAACCCTCGTGGACTCACCGGGGGACAGGCCGAGGCACTCGCGGGCGCCGATGTGTTCCTGGGTGTTTCGGCGGG
CAAGGTCGACGAATCGCTCATCGCGACCATGGCCGATGACAGCATCGTCTTCGCCTGTTCCAACCCCGATCCTGAGATTC
ATCCGCATGTCGCGGCCAAGTACGCCGCGATCGTGGCGACCGGGCGCAGTGACTTCCCGAACCAGATCAACAACGTGCTG
GCCTTCCCCGGTGTATTCCGCGGGGCATTGGACGCCGAGGCCACCAAGATTACCGAGCGGATGAAAGTGGCGGCGGCCGA
GGCGATTTTCTCTGTTGTGGAGCCGGAGCTGGCGCCCAACAAGATTGTGCCCAGCCCACTGGACCCGCGCGTCGGGCCGG
CCGTGGCCGCCGCTGTGCAGGCCGTCGCGCACGAGAGCGACTAG

Upstream 100 bases:

>100_bases
CGCCGAGTCGGTACGCGGATTCGTGGCGGGCGCGTAACGGGCCGCTCACAGTTCCAGAGTCGCCACCAGTGACATGCAAG
GGGGACAGTAGTCTCACGCT

Downstream 100 bases:

>100_bases
CCGTTTGAGGTTGCGTAGGTGGACGGCGGTGCTGCTGGCGGCAGTGGCTGTTCTGGCCGGTTGCTCGGAAAACCACGGCC
CGGCACCGTATCTCACGGTG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTASDVVVTDEEIFEAHIDGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIAADASLAKKYTWAHRLVAVVSDGSAVLGL
GDIGPSASLPVMEGKSALFKTFAGLNSIPIVLDTKDPDEIVETLIRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVM
HDDQHGTAIVVLAALMGASRVLGRDQQSLKVVISGAGAAGVACANILLADGINDVTVLDSKGIVHTSRDDLNEFKADLAA
RTNPRGLTGGQAEALAGADVFLGVSAGKVDESLIATMADDSIVFACSNPDPEIHPHVAAKYAAIVATGRSDFPNQINNVL
AFPGVFRGALDAEATKITERMKVAAAEAIFSVVEPELAPNKIVPSPLDPRVGPAVAAAVQAVAHESD

Sequences:

>Translated_387_residues
MTASDVVVTDEEIFEAHIDGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIAADASLAKKYTWAHRLVAVVSDGSAVLGL
GDIGPSASLPVMEGKSALFKTFAGLNSIPIVLDTKDPDEIVETLIRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVM
HDDQHGTAIVVLAALMGASRVLGRDQQSLKVVISGAGAAGVACANILLADGINDVTVLDSKGIVHTSRDDLNEFKADLAA
RTNPRGLTGGQAEALAGADVFLGVSAGKVDESLIATMADDSIVFACSNPDPEIHPHVAAKYAAIVATGRSDFPNQINNVL
AFPGVFRGALDAEATKITERMKVAAAEAIFSVVEPELAPNKIVPSPLDPRVGPAVAAAVQAVAHESD
>Mature_386_residues
TASDVVVTDEEIFEAHIDGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIAADASLAKKYTWAHRLVAVVSDGSAVLGLG
DIGPSASLPVMEGKSALFKTFAGLNSIPIVLDTKDPDEIVETLIRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMH
DDQHGTAIVVLAALMGASRVLGRDQQSLKVVISGAGAAGVACANILLADGINDVTVLDSKGIVHTSRDDLNEFKADLAAR
TNPRGLTGGQAEALAGADVFLGVSAGKVDESLIATMADDSIVFACSNPDPEIHPHVAAKYAAIVATGRSDFPNQINNVLA
FPGVFRGALDAEATKITERMKVAAAEAIFSVVEPELAPNKIVPSPLDPRVGPAVAAAVQAVAHESD

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=361, Percent_Identity=25.4847645429363, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI62420882, Length=358, Percent_Identity=25.1396648044693, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI62420880, Length=358, Percent_Identity=25.1396648044693, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI239049447, Length=358, Percent_Identity=25.1396648044693, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788806, Length=396, Percent_Identity=44.1919191919192, Blast_Score=314, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI17537199, Length=403, Percent_Identity=24.8138957816377, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=345, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356279, Length=353, Percent_Identity=26.628895184136, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646386, Length=379, Percent_Identity=25.8575197889182, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362674, Length=353, Percent_Identity=26.628895184136, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362672, Length=353, Percent_Identity=26.628895184136, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646388, Length=379, Percent_Identity=25.8575197889182, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363503, Length=410, Percent_Identity=24.6341463414634, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707232, Length=410, Percent_Identity=24.6341463414634, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363505, Length=410, Percent_Identity=24.6341463414634, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707236, Length=410, Percent_Identity=24.6341463414634, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707240, Length=359, Percent_Identity=25.6267409470752, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI78707242, Length=359, Percent_Identity=25.6267409470752, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI78707238, Length=359, Percent_Identity=25.6267409470752, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 40335; Mature: 40204

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASDVVVTDEEIFEAHIDGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIAADASLAKK
CCCCCEEEEHHHHHHHHCCCEEEEEECCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHH
YTWAHRLVAVVSDGSAVLGLGDIGPSASLPVMEGKSALFKTFAGLNSIPIVLDTKDPDEI
HHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHH
VETLIRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAALMGASR
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHH
VLGRDQQSLKVVISGAGAAGVACANILLADGINDVTVLDSKGIVHTSRDDLNEFKADLAA
HHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHHHHHHHHHHHH
RTNPRGLTGGQAEALAGADVFLGVSAGKVDESLIATMADDSIVFACSNPDPEIHPHVAAK
CCCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHEECCCCEEEEECCCCCCCCCHHHHH
YAAIVATGRSDFPNQINNVLAFPGVFRGALDAEATKITERMKVAAAEAIFSVVEPELAPN
EEEEEECCCCCCCHHHHHHEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KIVPSPLDPRVGPAVAAAVQAVAHESD
CCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TASDVVVTDEEIFEAHIDGKLSVELKSPLDTQRALSIAYTPGVAQVSRAIAADASLAKK
CCCCEEEEHHHHHHHHCCCEEEEEECCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHH
YTWAHRLVAVVSDGSAVLGLGDIGPSASLPVMEGKSALFKTFAGLNSIPIVLDTKDPDEI
HHHHHHEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCHHHH
VETLIRLRPTFGAVNLEDISAPRCFEIERRVIEALDCPVMHDDQHGTAIVVLAALMGASR
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHH
VLGRDQQSLKVVISGAGAAGVACANILLADGINDVTVLDSKGIVHTSRDDLNEFKADLAA
HHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHHHHHHHHHHHH
RTNPRGLTGGQAEALAGADVFLGVSAGKVDESLIATMADDSIVFACSNPDPEIHPHVAAK
CCCCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHEECCCCEEEEECCCCCCCCCHHHHH
YAAIVATGRSDFPNQINNVLAFPGVFRGALDAEATKITERMKVAAAEAIFSVVEPELAPN
EEEEEECCCCCCCHHHHHHEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KIVPSPLDPRVGPAVAAAVQAVAHESD
CCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]