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The map label for this gene is fumC [H]

Identifier: 169628343

GI number: 169628343

Start: 1257538

End: 1258938

Strand: Reverse

Name: fumC [H]

Synonym: MAB_1250c

Alternate gene names: 169628343

Gene position: 1258938-1257538 (Counterclockwise)

Preceding gene: 169628344

Following gene: 169628340

Centisome position: 24.84

GC content: 65.38

Gene sequence:

>1401_bases
TTGTCTGAACAGCAGTACCGCATCGAGCACGACACCATGGGCGAGGTCCGGGTGCCCGCGGAAGCACTGTGGCGCGCGCA
GACCCAGCGCGCGGTCGAGAACTTTCCCATCTCGGGACGCGGCCTGGAGCGCACGCAGATCCGGGCCCTCGGCCTGCTGA
AGGGCGCCTGCGCACAGGTCAACAAGGACCTGGGGCTGCTGGCTGCGGAGAAGGCCGATGCGATTATCGCTGCGGCACAG
GAGATCGCCGACGGAAAGCACGACGACCAGTTCCCCATCGATGTCTTCCAGACCGGCTCGGGCACCAGCTCGAATATGAA
CGCCAACGAGGTGATCGCCAGTATTGCGGCACAGGCGACGCCACCGGTTGTCGTGCACCCGAATGACGACGTGAACATGT
CGCAGTCCTCCAATGACACCTTCCCGACGGCGACCCACCTGGCCGCGACCGAAGCTGCTGTGCGCGACCTGATTCCGGCA
CTGGAGTACCTCCAGCAGGCACTGGCCACCAAGGCCAAGGCCTGGAAGACCGTCGTGAAGTCCGGCCGCACGCACCTAAT
GGACGCGGTTCCGGTGACGCTGGGCCAGGAGTTCGGCGGCTACGCCCGTCAGATCGAGGCCGGCATAGAACGGGTCAAGG
CGACGCTGCCCCGCCTCGGCGAGCTGCCCATCGGCGGTACCGCCGTGGGCACCGGCCTGAACGCCCCCGACGGCTTTGGT
GCGAAAGTTGTTGAGGTACTGAAGCAGTCGACGGGCCTGTCGGAGCTCAAGACCGCTTCTGACTCGTTCGAGGCACAGGC
CGCCCGTGACGGGCTGGTTGAGGGCTCGGGCGCGCTGAAGACCATCGCGGCATCGCTGACCAAGATCGCCAACGACATTC
GCTGGATGGGCTCGGGCCCGCTCACCGGCCTGGGCGAGATCCAGCTTCCCGATCTGCAGCCCGGCAGCTCGATCATGCCC
GGCAAGGTCAACCCGGTGCTGCCCGAGGCCGTCACACAGGTCGCGGCGCAGGTCATCGGTAACGATGCCGCCATCACGGT
GGGTGGCTTGTCCGGCGCCTTCGAGCTCAACGTGTACATCCCGGTCATGGCCCGCAACCTGCTGGAGTCGTTCACGCTGC
TGGCCAACGTATCTCGCCTGTTCGTCGACAAGTGTGTCGATGGCCTGGTGGCCAACGAGGATCACCTGCGGACGCTGGCG
GAGTCCTCGCCGTCAATCGTTACCCCGTTGAACTCGGCCATCGGCTATGAAGAAGCGGCGGCCGTCGCCAAGGAAGCGCT
CAAGGAGCGCAAGACGATTCGGCAGACGGTCATCGATCGCGGCCTCATCGGCGACAAGCTGAGCATCGAGGAACTGGACA
AGCGCCTCGACGTGCTCGCCATGGCAAAGGTGAAGGACTAG

Upstream 100 bases:

>100_bases
CACCAAACTCCGCGAATACTCCGCGGTCGACTTCATGGGCGACGACGACGCCACCCACCCCCTCCCCTAATTCCATCATC
GACGACGAGAAGGAAAACCA

Downstream 100 bases:

>100_bases
CCAGTCCCGTCACCCCGGGCGCCTAGTAGGACGGCAGGACGATGTCCTCCCAGGTGACGGTGATGTTCGGTGGCTCGATA
CCGATGATGTCGGTGACCAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQ
EIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPA
LEYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFG
AKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMP
GKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLA
ESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD

Sequences:

>Translated_466_residues
MSEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQ
EIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPA
LEYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFG
AKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMP
GKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLA
ESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD
>Mature_465_residues
SEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQE
IADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPAL
EYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFGA
KVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMPG
KVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLAE
SSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=50.2173913043478, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1787896, Length=428, Percent_Identity=50.9345794392523, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI87082375, Length=460, Percent_Identity=40, Blast_Score=308, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17553882, Length=452, Percent_Identity=51.5486725663717, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI32565146, Length=314, Percent_Identity=53.1847133757962, Blast_Score=325, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324993, Length=448, Percent_Identity=50.8928571428571, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24640179, Length=457, Percent_Identity=48.7964989059081, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24640177, Length=457, Percent_Identity=48.5776805251641, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78710009, Length=448, Percent_Identity=49.5535714285714, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24662684, Length=447, Percent_Identity=47.2035794183445, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583245, Length=445, Percent_Identity=41.5730337078652, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49223; Mature: 49091

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQV
CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NKDLGLLAAEKADAIIAAAQEIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQAT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCC
PPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVK
CCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCC
AKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGP
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
LTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYI
CCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEH
PVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEECCHHHHCCHHHHH
AVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQV
CCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NKDLGLLAAEKADAIIAAAQEIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQAT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCC
PPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVK
CCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCC
AKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGP
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
LTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYI
CCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEH
PVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEECCHHHHCCHHHHH
AVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]