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The map label for this gene is glyA [H]

Identifier: 169628329

GI number: 169628329

Start: 1248144

End: 1249601

Strand: Direct

Name: glyA [H]

Synonym: MAB_1236

Alternate gene names: 169628329

Gene position: 1248144-1249601 (Clockwise)

Preceding gene: 169628328

Following gene: 169628330

Centisome position: 24.63

GC content: 68.24

Gene sequence:

>1458_bases
ATGACGACTTCAGCCTCCAGCGATATCGCGCAGGGTGCGCAGTATGCCGAGACCGCCAGCGCCGCCTACCGGTCGGCGCT
GCAGGTCATCGAGACCATCGAGCCGCGCATCGCGGACGCTACCCGCAAAGAGCTTGCCGACCAACGTGATTCGCTGAAGC
TGATCGCCAGCGAGAACTACGCCTCGCCGGCTGTGTTGCTGACCATGGGCACCTGGCTCTCGGACAAGTACGCCGAGGGC
ACCATCGGTCACCGCTTCTACGCCGGTTGCCAGAACATCGACACCGTCGAGGCGCTGGCCGCCGAGCATGCCCGCGAGCT
GTTTGGCGCGCCGTACGCGTACGCGCAGCCGCACTCCGGTATCGACGCCAATCTCGTTGCCTACTGGGCGATCCTGGCCA
CCCGGGTAGAGGCACCGGCGCTGGCGGATAAGGGCGTGCGCAATGTCAACGACCTGTCCGAGACCGACTGGGAGGAGCTG
CGTCACCAGTACGGCAACCAGCGGCTGATGGGCATGTCGCTGGACGCCGGCGGGCACCTGACGCACGGCTTCCGGCCCAA
CATCTCCGGCAAGATGTTCCACCAGCGCAGCTACGGAACCGATCCGGAGACGGGCTTGCTGGACTATGACGCGCTGGCCG
CCGCGGCCCGCGAGTTCAAGCCGTTGGTGTTGGTGGGCGGCTACTCCGCGTACCCGCGCCGGGTGAACTTCGCCAAGCTG
CGTGAGATCGCCGACGAGGTGGGTGCCACCTTGTTCGTGGACATGGCCCACTTCGCCGGCCTGGTGGCCGGAAAGGTGTT
CACCGGCGACGAGAACCCGGTGCCGCACGCCCACATCACGACCACCACCACCCACAAGTCGCTGCGCGGCCCACGCGGTG
GCCTGGTGCTGGCCACCGCCGAGTACTCCGACGCCGTGGACAAGGGTTGCCCGATGGTGCTGGGCGGACCGCTGTCCCAC
GTGATGGCCGCCAAGGCTGTCGCCCTGGCCGAGGCACGTCAGCCGTCATTCCAGGCTTACGCACAGCGCGTCGCCGACAA
CGCCAAGTCGCTGGCCGAGGGCTTCCTCAAGCGGGGCGCGCGCCTGGTCACCGGCGGCACCGACAATCACCTGGTGCTCC
TGGACGTGCAGTCCTTCGGGCTCACCGGGCGCCAGGCCGAATCGGCCCTGCTGGACGCGGGCGTCGTCACCAACCGCAAC
GCCATCCCGGCCGACCCCAACGGCGCCTGGTACACCAGCGGCATCCGCTTCGGAACGCCGGCGCTCACCAGCCGCGGATT
CGGCGCCGACGAGTTCGACAAGGTGGCCGAGCTGGTGGTCGACGTGCTGACCAATACCGAGGCCGATGGGTCTTCCAAGG
CCAAGTACACCCTGGCCGACGCAGTGGCGGAGCGGGTGAAGGCCGCCTCGGCCGAGCTGCTGGCCGCCAACCCCCTGTAC
CCGGGCCTCACTTTGTAG

Upstream 100 bases:

>100_bases
GCGCCCGGCGGAGCAGTCGCTGACGGCCCGCTTCGGCAGGCTGCTCGATGAGCCCCTGGTGGCGTCCACGTTGGTGTAGC
CGCCGACTAGGCTGATGGCC

Downstream 100 bases:

>100_bases
GGACCTTAGTCCCGCCGACACGCCGCGTTCTGTTGCAAACAGCCTGGACAACCATGCAAAACACGGCGTGTCGGCGCGAG
AAGGAACTGTCGCGCGGCGA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKELADQRDSLKLIASENYASPAVLLTMGTWLSDKYAEG
TIGHRFYAGCQNIDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPALADKGVRNVNDLSETDWEEL
RHQYGNQRLMGMSLDAGGHLTHGFRPNISGKMFHQRSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKL
REIADEVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGLVLATAEYSDAVDKGCPMVLGGPLSH
VMAAKAVALAEARQPSFQAYAQRVADNAKSLAEGFLKRGARLVTGGTDNHLVLLDVQSFGLTGRQAESALLDAGVVTNRN
AIPADPNGAWYTSGIRFGTPALTSRGFGADEFDKVAELVVDVLTNTEADGSSKAKYTLADAVAERVKAASAELLAANPLY
PGLTL

Sequences:

>Translated_485_residues
MTTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKELADQRDSLKLIASENYASPAVLLTMGTWLSDKYAEG
TIGHRFYAGCQNIDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPALADKGVRNVNDLSETDWEEL
RHQYGNQRLMGMSLDAGGHLTHGFRPNISGKMFHQRSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKL
REIADEVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGLVLATAEYSDAVDKGCPMVLGGPLSH
VMAAKAVALAEARQPSFQAYAQRVADNAKSLAEGFLKRGARLVTGGTDNHLVLLDVQSFGLTGRQAESALLDAGVVTNRN
AIPADPNGAWYTSGIRFGTPALTSRGFGADEFDKVAELVVDVLTNTEADGSSKAKYTLADAVAERVKAASAELLAANPLY
PGLTL
>Mature_484_residues
TTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKELADQRDSLKLIASENYASPAVLLTMGTWLSDKYAEGT
IGHRFYAGCQNIDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAYWAILATRVEAPALADKGVRNVNDLSETDWEELR
HQYGNQRLMGMSLDAGGHLTHGFRPNISGKMFHQRSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKLR
EIADEVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGLVLATAEYSDAVDKGCPMVLGGPLSHV
MAAKAVALAEARQPSFQAYAQRVADNAKSLAEGFLKRGARLVTGGTDNHLVLLDVQSFGLTGRQAESALLDAGVVTNRNA
IPADPNGAWYTSGIRFGTPALTSRGFGADEFDKVAELVVDVLTNTEADGSSKAKYTLADAVAERVKAASAELLAANPLYP
GLTL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI261862350, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI261862348, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI19923315, Length=431, Percent_Identity=37.8190255220418, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI261862346, Length=431, Percent_Identity=36.4269141531323, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI22547186, Length=488, Percent_Identity=35.0409836065574, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI22547189, Length=472, Percent_Identity=35.1694915254237, Blast_Score=236, Evalue=4e-62,
Organism=Escherichia coli, GI1788902, Length=445, Percent_Identity=45.3932584269663, Blast_Score=348, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=434, Percent_Identity=37.7880184331797, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI25144732, Length=434, Percent_Identity=37.7880184331797, Blast_Score=277, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6319739, Length=431, Percent_Identity=38.2830626450116, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323087, Length=431, Percent_Identity=35.9628770301624, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24640005, Length=430, Percent_Identity=38.8372093023256, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI221329721, Length=430, Percent_Identity=38.8372093023256, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 51657; Mature: 51526

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00096 SHMT ; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKELADQRDSLKLIASENY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHCEEEEECCCC
ASPAVLLTMGTWLSDKYAEGTIGHRFYAGCQNIDTVEALAAEHARELFGAPYAYAQPHSG
CCCEEEEEECCHHCCHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
IDANLVAYWAILATRVEAPALADKGVRNVNDLSETDWEELRHQYGNQRLMGMSLDAGGHL
CCHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCC
THGFRPNISGKMFHQRSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKL
CCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHH
REIADEVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGLVLATA
HHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCCCCCCEEEEECCHHHHCCCCCCEEEEEC
EYSDAVDKGCPMVLGGPLSHVMAAKAVALAEARQPSFQAYAQRVADNAKSLAEGFLKRGA
CHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RLVTGGTDNHLVLLDVQSFGLTGRQAESALLDAGVVTNRNAIPADPNGAWYTSGIRFGTP
EEEECCCCCEEEEEEEHHCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEECCCCCCCC
ALTSRGFGADEFDKVAELVVDVLTNTEADGSSKAKYTLADAVAERVKAASAELLAANPLY
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCC
PGLTL
CCCCC
>Mature Secondary Structure 
TTSASSDIAQGAQYAETASAAYRSALQVIETIEPRIADATRKELADQRDSLKLIASENY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHCEEEEECCCC
ASPAVLLTMGTWLSDKYAEGTIGHRFYAGCQNIDTVEALAAEHARELFGAPYAYAQPHSG
CCCEEEEEECCHHCCHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
IDANLVAYWAILATRVEAPALADKGVRNVNDLSETDWEELRHQYGNQRLMGMSLDAGGHL
CCHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCC
THGFRPNISGKMFHQRSYGTDPETGLLDYDALAAAAREFKPLVLVGGYSAYPRRVNFAKL
CCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHH
REIADEVGATLFVDMAHFAGLVAGKVFTGDENPVPHAHITTTTTHKSLRGPRGGLVLATA
HHHHHHHCHHHHHHHHHHHHHHHCEEECCCCCCCCCCEEEEECCHHHHCCCCCCEEEEEC
EYSDAVDKGCPMVLGGPLSHVMAAKAVALAEARQPSFQAYAQRVADNAKSLAEGFLKRGA
CHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RLVTGGTDNHLVLLDVQSFGLTGRQAESALLDAGVVTNRNAIPADPNGAWYTSGIRFGTP
EEEECCCCCEEEEEEEHHCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEECCCCCCCC
ALTSRGFGADEFDKVAELVVDVLTNTEADGSSKAKYTLADAVAERVKAASAELLAANPLY
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCC
PGLTL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA