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The map label for this gene is cbs [H]

Identifier: 169628288

GI number: 169628288

Start: 1209775

End: 1211184

Strand: Direct

Name: cbs [H]

Synonym: MAB_1195

Alternate gene names: 169628288

Gene position: 1209775-1211184 (Clockwise)

Preceding gene: 169628287

Following gene: 169628289

Centisome position: 23.87

GC content: 66.1

Gene sequence:

>1410_bases
ATGCGCATCGCCCAGCATGTCTCGGATCTGATCGGCAACACCCCTCTCGTCCGGCTCAACTCGGTGGTGCCCGAGGGCTG
CGCGACGGTGGCCGCCAAGATCGAATACCTCAATCCCGGCGGCAGCTCGAAGGACCGCATCGCCGTCAAGATGATCGAGG
CCGCCGAGGAGGCGGGGCTGCTCAAGCCTGGCGGCACCATCGTCGAGCCCACCTCGGGCAATACCGGGGTTGGGCTCGCG
CTGGTCGCGCAGCGCAAGGGATACCACTGCGTGTTCGTGTGCCCCGACAAGGTCAGCGAGGACAAGCGGAATGTGTTGCG
GGCCTACGGGGCCGAGGTCGTCGTGTGCCCCACGGCGGTTCCGCCGGAGCATCCCGACAGCTACTACAACGTCTCGGACC
GCCTGGTGCGTGAGATCGAGGGCGCCTGGAAGCCCGACCAATACTCCAACCCGAACGGCCCCGCCAGCCATTACGAGACC
ACCGGCCCGGAAATCTGGGCCGATACCGACGGCAAGATCACCCATTTCGTCGCCGGGGTGGGCACCGGTGGCACCATCAC
CGGCGCGGGCCGATACCTCAAAGAGGTCTCCGGCGGCCGCGCAATAGGCGAGGTCAAGATCGTCGGTGCCGACCCGGAGG
GGTCCGTCTACTCCGGCGGCACGGGCCGTCCCTACCTTGTCGAAGGTGTGGGAGAGGATTTCTGGCCCTCTGCTTATGAC
CCCAGCGTGGTCGACGAGGTCATCGCGGTGTCCGATGCCGACTCCTTCGAGATGACCCGGCGGCTGGCGCGAGAAGAAGG
GTTGCTGGTCGGCGGATCCTGCGGCATGGCCGTGGTGGCGGCAATTCGGTTGGCAGAGAAGGTGGGCCCCGACGGACTGG
TCGTGGTGCTGTTGCCGGACGGTGGCCGCGGATACTTGTCCAAGGTGTTCAACGACGCCTGGATGTCTTCGTACGGATTT
TTGCGTAGCCGTTTGGACGGCAGCGTCTCCGAGCCCACCGTGGGTGACGTGCTGCGTGGAAAGTCCGGTGCGCTACCTGA
TTTGGTACACACCCATCCGTCGGAGACGGTGCGCGACGCCATCGAGATCTTGCGCGAGTACGGGGTGTCCCAGATGCCCG
TGGTGGGGGCCGAGCCGCCCGTCATGGCGGGCGAGGTGGCCGGATCGGTCTCCGAAAGAGAGCTGCTGTCAGCGGTATTC
GAAGGCCGGGCACAGCTTGCCGATGCCGTCGCTCAGCACATGAGCCCACCATTGCCGCTGGTCGGCTCGGGTGAGCCGCT
GAGTACCGCCGGATCCATGCTGCGCGACACCGACGCGGTGATGGTCGTCGACGAGGGCAAGCCCGTTGGTGTCATCACCC
GCCATGACCTGCTGGGATTCGTCTCATCCGGTAGGGGCGTACGGCACTGA

Upstream 100 bases:

>100_bases
CGCGCCCGCGGCGGTCTGATCGGCGTTCTGGGCCCTCGCCGGATGCCTGTGTGGGAGCCTCTGCGCGCGGGACACTCATC
GGTCTAATAGCGTTACCTGC

Downstream 100 bases:

>100_bases
TTTTCGCGCCAAATCGTTTCGCAGAAGCCAACCTGTGGAAACGCTGAACGCGTAATGTCCTCTGTTGCTCGACGCTGATG
CGTGTCATACGAAACTGGAG

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVKMIEAAEEAGLLKPGGTIVEPTSGNTGVGLA
LVAQRKGYHCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSNPNGPASHYET
TGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGRAIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYD
PSVVDEVIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPDGGRGYLSKVFNDAWMSSYGF
LRSRLDGSVSEPTVGDVLRGKSGALPDLVHTHPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVGVITRHDLLGFVSSGRGVRH

Sequences:

>Translated_469_residues
MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVKMIEAAEEAGLLKPGGTIVEPTSGNTGVGLA
LVAQRKGYHCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSNPNGPASHYET
TGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGRAIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYD
PSVVDEVIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPDGGRGYLSKVFNDAWMSSYGF
LRSRLDGSVSEPTVGDVLRGKSGALPDLVHTHPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVGVITRHDLLGFVSSGRGVRH
>Mature_469_residues
MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVKMIEAAEEAGLLKPGGTIVEPTSGNTGVGLA
LVAQRKGYHCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSNPNGPASHYET
TGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGRAIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYD
PSVVDEVIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPDGGRGYLSKVFNDAWMSSYGF
LRSRLDGSVSEPTVGDVLRGKSGALPDLVHTHPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVGVITRHDLLGFVSSGRGVRH

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=484, Percent_Identity=39.4628099173554, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI295821200, Length=484, Percent_Identity=39.4628099173554, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI4557415, Length=484, Percent_Identity=39.4628099173554, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=40.5750798722045, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=39.4984326018809, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=333, Percent_Identity=45.6456456456456, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17562970, Length=315, Percent_Identity=41.2698412698413, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.0976430976431, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=333, Percent_Identity=40.8408408408408, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25147552, Length=327, Percent_Identity=42.2018348623853, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=40.0662251655629, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=41.6403785488959, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=222, Percent_Identity=38.7387387387387, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71996324, Length=355, Percent_Identity=23.6619718309859, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=507, Percent_Identity=33.9250493096647, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6321449, Length=336, Percent_Identity=36.3095238095238, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24643623, Length=488, Percent_Identity=36.0655737704918, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI20129101, Length=488, Percent_Identity=36.0655737704918, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49238; Mature: 49238

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVKMIEAAEEAGL
CCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCC
LKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAV
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCC
PPEHPDSYYNVSDRLVREIEGAWKPDQYSNPNGPASHYETTGPEIWADTDGKITHFVAGV
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGRAIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYD
CCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCC
PSVVDEVIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPD
HHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECC
GGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPDLVHTHPSETVRDA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHCCCHHHHHHH
IEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAQLADAVAQHMSPPLPL
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VGSGEPLSTAGSMLRDTDAVMVVDEGKPVGVITRHDLLGFVSSGRGVRH
CCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVKMIEAAEEAGL
CCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCC
LKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAV
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCC
PPEHPDSYYNVSDRLVREIEGAWKPDQYSNPNGPASHYETTGPEIWADTDGKITHFVAGV
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGRAIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYD
CCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCC
PSVVDEVIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPD
HHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECC
GGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPDLVHTHPSETVRDA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHCCCHHHHHHH
IEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAQLADAVAQHMSPPLPL
HHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VGSGEPLSTAGSMLRDTDAVMVVDEGKPVGVITRHDLLGFVSSGRGVRH
CCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]