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The map label for this gene is mazG [H]

Identifier: 169628251

GI number: 169628251

Start: 1172828

End: 1173880

Strand: Direct

Name: mazG [H]

Synonym: MAB_1158

Alternate gene names: 169628251

Gene position: 1172828-1173880 (Clockwise)

Preceding gene: 169628250

Following gene: 169628252

Centisome position: 23.15

GC content: 65.53

Gene sequence:

>1053_bases
ATGACCGTCATACTCGTCGACCCACGCCATCCGTCGATGGTTCCGGTCGAGGCGGTCGCGTTGCTCGCCGGTGATCTGCA
GTACACGGAGGAACTGCCGGTGCGGCTGGCGTGGTCGCTGTCGACGGCGCGCCCGGTGTACATCGGCGAGGACGCTCCCG
CCCTGTTGTCCTCGGATCCAGACCATCCGGAGGTGCGCGCGCGGGTCAAGGCGGGCGCCGCGGTCATCGCACCGCCGGCA
CGGCAAGGTGAAAAGCTCATCGACGCGGTAGCGGTGATGGACAGGCTGCGGACGAACGGGCCGTGGGAGAGCACTCAGAC
GCACGATTCGTTGCGTCGGTATCTGCTCGAGGAGACCTACGAGCTTTTTGATGCCGTGCGCACCGGGGACGCCGACGAGC
TTCGTGAGGAATTGGGCGATGTATTGCTACAGGTGCTCTTTCACGCGCGTATCGCCGAGGACGCCCCGGAGCACCCGTTC
AATATCGACGATGTGGCCGAGACGCTGCTGAGCAAACTGGGCAACCGCATCCCGGTCCTGCTCGGTGCCGGTGGTGATTC
CGCCTCGATCTCACTGGAAGAGCAATTGGCGCAGTGGGAAGAACGCAAGGCCGAGGAGAAGAAAGACCGGGACTCCTGCC
TGGATGGCATATCCAGTAGTCAACCCGCGCTTGCGCTTACTCAGAAGGTGCTGGGCAGGGTGACGGCCGCGGGTCTGCCC
GCGGAGCTGATTCCCGCACAACTGTTGTCGGTGCGCATCGACCCCGACGGTGACGCCGAAAACCAGCTCCGTGCCGATGC
TTTGGAATTCATGGACACCGTGCGGCGCGCCGAGAAGGACATCCTGCGGGGACGTCGCGGCGACGACGTGGCCTCTGAGC
TGGATGTCAGCGATCTGCGCGAGGTGAGCACGGAGGAATGGCGCGCGCACTGGCGGCAGGCCCCCGCAGACCCCGCGGCG
GCCACGGAGACGGATCTCACCGCTGAAGAGCAGCAGCCTGACGTGCATGACGACGAGGAAGCCGCGGATTCCGGCCGGCC
GAAGAGTGCCTAG

Upstream 100 bases:

>100_bases
TTCGGGACCTAGAGCTTGTGCACATGATCGCCGAGCTGTTGGTCGCGTTGTCCGGGCGCCCGGCGGGCAGTGTTGATATA
ACACCACTGGAGGTGAGCAA

Downstream 100 bases:

>100_bases
CTCCGGTATCTGTAGCTAAATTCACGGCGGACGGGACTTTATGCCCGTCGTGTCGGGACCATTGCCCGTGAGGGTATTTG
CACTGCGTATTAGGGGTGCC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIGEDAPALLSSDPDHPEVRARVKAGAAVIAPPA
RQGEKLIDAVAVMDRLRTNGPWESTQTHDSLRRYLLEETYELFDAVRTGDADELREELGDVLLQVLFHARIAEDAPEHPF
NIDDVAETLLSKLGNRIPVLLGAGGDSASISLEEQLAQWEERKAEEKKDRDSCLDGISSSQPALALTQKVLGRVTAAGLP
AELIPAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASELDVSDLREVSTEEWRAHWRQAPADPAA
ATETDLTAEEQQPDVHDDEEAADSGRPKSA

Sequences:

>Translated_350_residues
MTVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIGEDAPALLSSDPDHPEVRARVKAGAAVIAPPA
RQGEKLIDAVAVMDRLRTNGPWESTQTHDSLRRYLLEETYELFDAVRTGDADELREELGDVLLQVLFHARIAEDAPEHPF
NIDDVAETLLSKLGNRIPVLLGAGGDSASISLEEQLAQWEERKAEEKKDRDSCLDGISSSQPALALTQKVLGRVTAAGLP
AELIPAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASELDVSDLREVSTEEWRAHWRQAPADPAA
ATETDLTAEEQQPDVHDDEEAADSGRPKSA
>Mature_349_residues
TVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIGEDAPALLSSDPDHPEVRARVKAGAAVIAPPAR
QGEKLIDAVAVMDRLRTNGPWESTQTHDSLRRYLLEETYELFDAVRTGDADELREELGDVLLQVLFHARIAEDAPEHPFN
IDDVAETLLSKLGNRIPVLLGAGGDSASISLEEQLAQWEERKAEEKKDRDSCLDGISSSQPALALTQKVLGRVTAAGLPA
ELIPAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASELDVSDLREVSTEEWRAHWRQAPADPAAA
TETDLTAEEQQPDVHDDEEAADSGRPKSA

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=155, Percent_Identity=40.6451612903226, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 38330; Mature: 38199

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIGEDAPALLSSDP
CEEEEECCCCCCCCHHHHHHHHHHCHHHHHHCCEEEEEECCCCCCEEECCCCCHHHCCCC
DHPEVRARVKAGAAVIAPPARQGEKLIDAVAVMDRLRTNGPWESTQTHDSLRRYLLEETY
CCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ELFDAVRTGDADELREELGDVLLQVLFHARIAEDAPEHPFNIDDVAETLLSKLGNRIPVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEE
LGAGGDSASISLEEQLAQWEERKAEEKKDRDSCLDGISSSQPALALTQKVLGRVTAAGLP
EECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
AELIPAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASELDVSDLR
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
EVSTEEWRAHWRQAPADPAAATETDLTAEEQQPDVHDDEEAADSGRPKSA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TVILVDPRHPSMVPVEAVALLAGDLQYTEELPVRLAWSLSTARPVYIGEDAPALLSSDP
EEEEECCCCCCCCHHHHHHHHHHCHHHHHHCCEEEEEECCCCCCEEECCCCCHHHCCCC
DHPEVRARVKAGAAVIAPPARQGEKLIDAVAVMDRLRTNGPWESTQTHDSLRRYLLEETY
CCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
ELFDAVRTGDADELREELGDVLLQVLFHARIAEDAPEHPFNIDDVAETLLSKLGNRIPVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEE
LGAGGDSASISLEEQLAQWEERKAEEKKDRDSCLDGISSSQPALALTQKVLGRVTAAGLP
EECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
AELIPAQLLSVRIDPDGDAENQLRADALEFMDTVRRAEKDILRGRRGDDVASELDVSDLR
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
EVSTEEWRAHWRQAPADPAAATETDLTAEEQQPDVHDDEEAADSGRPKSA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA