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The map label for this gene is fabH

Identifier: 169628234

GI number: 169628234

Start: 1157354

End: 1158376

Strand: Reverse

Name: fabH

Synonym: MAB_1141c

Alternate gene names: 169628234

Gene position: 1158376-1157354 (Counterclockwise)

Preceding gene: 169628235

Following gene: 169628231

Centisome position: 22.86

GC content: 66.18

Gene sequence:

>1023_bases
ATGACCGATATCGCGGAGATCACCGGCATCAACAAGATCGGCCTACTCAGCCTGGGGGCGTACCGACCCGAGCGCGTGGT
CACCAACGACGAGATCTGCGAGCGCATCGAGTCTTCGGACGAGTGGATCTACACCCGCACCGGCATCAAAACCCGGCGGT
TCGCCGCCGATGAGGAAACCGCTCAGACGCTGGCCATCGAGGCCGGGCGCAAGGCGATCGCCAATGCCTTGCTGACCGGT
GCCGAGATCGACGCGGTGATCGTCGCCACCAGCACGCACTACCTGCAGACGCCGGCCTCGGCCCCGGCCGTGGCCACCGC
GCTGGGCGCCCAAGGTGTCCCCGCCTTCGACCTGTCGGCCGGCTGCGCCGGATTCGGATACGCCGTGGGCGTGGCGGGCG
ACATGATCCGGGGCGGCAGCGCCAGCAAGGTGCTGGTGATCGGCTCGGAAAAACTCTCCCCCGCACTGGATATGACCGAT
CGCGGCAACTGTTTCATCTTCGGCGACGGGGCCGGCGCGGTTGTCGTCGGCGAGACCGCCGAACAAGGTATCGGCCCCAC
CGTGTGGGGTAGCGACGGCAGCCAATCCAACGCCATTCGGCAGGACATCGACTGGATGGACTTCGCGGCGGCACCCGATC
CGGAGGGCCCGCGCCCCTACTTACGTATCGAGGGTACGTCGGTATTCCGTTGGGCCGCATTCGAAATGGGTAAGGTCGGA
CAGCGAGCCATGGAAGCCGCGAAGGTGGGGCCCGAGCAGATCGATGTCTTCGTACCGCATCAGGCCAACACCCGGATCAA
CGAGCTGCTGGCCAAGAATCTGCACCTGCGCGCGGATGCGGTCATTGCCAATGACATCGAGCACACCGGCAACACCTCGG
CGGCATCGGTGCCGTTGGCCATGGAGACACTGCTGTCCACCGGCGCCGCCAAGCCGGGCGATCTGGCGCTGCTCATCGGC
TATGGCGCCGGGCTCAGCTACGCCGCACAGGTGGTCAGGATGCCTCCTGTGCCGTTCGAGTGA

Upstream 100 bases:

>100_bases
AGACGCCGCCGAGCTGCTGATTCGCCTCGGTCTGGAGGCAGCACAGAATCAGGTGCATGCCTGGGGTTAGATCCCTGGAT
GTGCCCGCTATGGTCTCCTC

Downstream 100 bases:

>100_bases
TGTCGCTGCGCGAATGTAACCGCACACATACGATCTGCGTCGATTCAGTGCGTGGCGTTACGTTCGGCGTTGGTCGTTCG
ACGCCTTGCGGTAGGCCCTA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLTG
AEIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSAGCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTD
RGNCFIFGDGAGAVVVGETAEQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVG
QRAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALLIG
YGAGLSYAAQVVRMPPVPFE

Sequences:

>Translated_340_residues
MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLTG
AEIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSAGCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTD
RGNCFIFGDGAGAVVVGETAEQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVG
QRAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALLIG
YGAGLSYAAQVVRMPPVPFE
>Mature_339_residues
TDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLTGA
EIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSAGCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDR
GNCFIFGDGAGAVVVGETAEQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVGQ
RAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALLIGY
GAGLSYAAQVVRMPPVPFE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=324, Percent_Identity=37.6543209876543, Blast_Score=214, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_MYCA9 (B1MKD7)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001701883.1
- ProteinModelPortal:   B1MKD7
- SMR:   B1MKD7
- EnsemblBacteria:   EBMYCT00000007009
- GeneID:   5963666
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_1141c
- GeneTree:   EBGT00050000016069
- HOGENOM:   HBG649927
- OMA:   VIANDIE
- ProtClustDB:   PRK09352
- BioCyc:   MABS561007:MAB_1141C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35547; Mature: 35415

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: ACT_SITE 122-122 ACT_SITE 260-260 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEET
CCCCHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEECCCHHH
AQTLAIEAGRKAIANALLTGAEIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCHHHHHHCCCCCCCEECCC
GCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDRGNCFIFGDGAGAVVVGETA
CCCCHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCH
EQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVG
HHCCCCEEECCCCCCCCHHHHCCCHHHCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHH
QRAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEECEEEECCHHCCCCCCCCCCHHH
METLLSTGAAKPGDLALLIGYGAGLSYAAQVVRMPPVPFE
HHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDEWIYTRTGIKTRRFAADEET
CCCHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEECCCHHH
AQTLAIEAGRKAIANALLTGAEIDAVIVATSTHYLQTPASAPAVATALGAQGVPAFDLSA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCHHHHHHCCCCCCCEECCC
GCAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDRGNCFIFGDGAGAVVVGETA
CCCCHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECCCH
EQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVG
HHCCCCEEECCCCCCCCHHHHCCCHHHCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHH
QRAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIANDIEHTGNTSAASVPLA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEECEEEECCHHCCCCCCCCCCHHH
METLLSTGAAKPGDLALLIGYGAGLSYAAQVVRMPPVPFE
HHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA