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The map label for this gene is iscS [H]

Identifier: 169628187

GI number: 169628187

Start: 1104494

End: 1105693

Strand: Reverse

Name: iscS [H]

Synonym: MAB_1093c

Alternate gene names: 169628187

Gene position: 1105693-1104494 (Counterclockwise)

Preceding gene: 169628193

Following gene: 169628180

Centisome position: 21.82

GC content: 61.58

Gene sequence:

>1200_bases
ATGACGGTAGACACGCCCACCGACAACCCGACCCAATTGCGATTTTCCGACAAGGAAACCGCAGGTCGGGTGGTCTACCT
GGATTCCAATGCCACGACGCCGGTCGACCCACGGGTGGCCGACGAGGTGTTGACGTACATGGCCCGCGAGTTCGGGAACG
CCGGCAGTCGCACACACGGATATGGCCAGGTGGCGAAGGAGCGAGTCGCCCGTGCCCGCGAGCAGGTCGCGGAGGTAGTC
CGCGCCCAGCCGGACGATGTGATATTCACCAGTGGCGCCACCGAGAGCAACAACCTCGCAATCCTCGGATTGGCCCCGTC
AGGCGAGAAGGCGAACCGACGACATATAGTGTCCACCCAGATTGAGCACAAGGCAGTCCTAGAGCCGCTCGCGATCCTCA
CGGATCGCGGCTTTGAGGTCACGCTCGTGCCGCCGACGCGTGGAGGGCGGATCGAACCGAGCGCCATTGCCGACGCAGTC
CGGCCGGACACCCTCTTGGTCTCGACAATGGCCGTCAACAATGAGACCGGCGTGATCCAGCCGATTCCCGAAATCGCCGA
AGTGCTTGCTCCGCACGACGCCTACCTTCACGTAGACGCGGCCCAAGCATTCGGAAAGATCATCGAACCCCTCCGAAATT
CGCGGATCGACATGCTTAGTGTCTCTGGCCACAAAGTGTTTGCCCCGAAGGGCATTGGGGCGCTCGTGGCGCGGCGACGC
GGTTACCGACGCGTGCCATTGCAGCCGCTGATGTTCGGCGGTGGCCAAGAACGAGGGCTGCGACCTGGAACACTGCCCGT
TGCTTTAATCGCCGGCTTGGGCCTTGCCGCAGAACTCGCCCTAAAGGAAAACGATGCACGGGCCCGACATGCTCTCGCGC
TCAAACATCAAGCACTGAACGCACTTTCAGAACTGGGTATCCAGGCAAACGGCGATGAAGAGCACACGGTCCCGCACACA
CTGAACTTCTCGGTGCCCGGCGTCGACGCGGAAGCCGCGATCGTTGCCCTCAAAGAAGTCGTCGCGATATCGAACGGTTC
CGCGTGCACCTCGCAGAAGTACGAACCTAGCCACGTTCTCGTCGCCGCCGATCTTCCGAAAAAGCAGATAGACGGTGCGC
TCCGCTTCTCATGGAGCCACTTAACCGGGGAAGTGCCCTGGGATGTTGTTGCACAGCGTCTCGCACAACTGGTGACATGA

Upstream 100 bases:

>100_bases
CTCATTGTCCTACCATAGTGCGTTGTTCGGAACAAGTGATCCGAACAGACGTCGGCGGTTCTCCGAACACATGTCAGAAC
CTACGCGTACGGTCTTGGCC

Downstream 100 bases:

>100_bases
ACGAACGGATCGACGCTCAAGATGTCTAAAGCGATCACGTAATCGCAGACCTGATAACTGTGAAATCCCCGACGGAAGAA
GGATATCCGTGACATCCGAC

Product: putative L-cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHGYGQVAKERVARAREQVAEVV
RAQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQIEHKAVLEPLAILTDRGFEVTLVPPTRGGRIEPSAIADAV
RPDTLLVSTMAVNNETGVIQPIPEIAEVLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVARRR
GYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDARARHALALKHQALNALSELGIQANGDEEHTVPHT
LNFSVPGVDAEAAIVALKEVVAISNGSACTSQKYEPSHVLVAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT

Sequences:

>Translated_399_residues
MTVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHGYGQVAKERVARAREQVAEVV
RAQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQIEHKAVLEPLAILTDRGFEVTLVPPTRGGRIEPSAIADAV
RPDTLLVSTMAVNNETGVIQPIPEIAEVLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVARRR
GYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDARARHALALKHQALNALSELGIQANGDEEHTVPHT
LNFSVPGVDAEAAIVALKEVVAISNGSACTSQKYEPSHVLVAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT
>Mature_398_residues
TVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHGYGQVAKERVARAREQVAEVVR
AQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQIEHKAVLEPLAILTDRGFEVTLVPPTRGGRIEPSAIADAVR
PDTLLVSTMAVNNETGVIQPIPEIAEVLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVARRRG
YRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDARARHALALKHQALNALSELGIQANGDEEHTVPHTL
NFSVPGVDAEAAIVALKEVVAISNGSACTSQKYEPSHVLVAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=43.2642487046632, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI156713448, Length=412, Percent_Identity=36.4077669902913, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI48994898, Length=363, Percent_Identity=44.9035812672176, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI1787970, Length=228, Percent_Identity=25.8771929824561, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789175, Length=237, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=360, Percent_Identity=45.2777777777778, Blast_Score=307, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17533177, Length=337, Percent_Identity=33.5311572700297, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319831, Length=377, Percent_Identity=44.5623342175066, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI20129463, Length=392, Percent_Identity=43.8775510204082, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42750; Mature: 42619

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHG
CCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YGQVAKERVARAREQVAEVVRAQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQ
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCEEEHHH
IEHKAVLEPLAILTDRGFEVTLVPPTRGGRIEPSAIADAVRPDTLLVSTMAVNNETGVIQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCCC
PIPEIAEVLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVARRR
CCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCHHHHHHHHC
GYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDARARHALALKHQALN
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHHHHHH
ALSELGIQANGDEEHTVPHTLNFSVPGVDAEAAIVALKEVVAISNGSACTSQKYEPSHVL
HHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
VAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT
EEECCCHHHHCCEEEEEEHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TVDTPTDNPTQLRFSDKETAGRVVYLDSNATTPVDPRVADEVLTYMAREFGNAGSRTHG
CCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YGQVAKERVARAREQVAEVVRAQPDDVIFTSGATESNNLAILGLAPSGEKANRRHIVSTQ
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCEEEHHH
IEHKAVLEPLAILTDRGFEVTLVPPTRGGRIEPSAIADAVRPDTLLVSTMAVNNETGVIQ
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCCCC
PIPEIAEVLAPHDAYLHVDAAQAFGKIIEPLRNSRIDMLSVSGHKVFAPKGIGALVARRR
CCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCHHHHHHHHC
GYRRVPLQPLMFGGGQERGLRPGTLPVALIAGLGLAAELALKENDARARHALALKHQALN
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHHHHHH
ALSELGIQANGDEEHTVPHTLNFSVPGVDAEAAIVALKEVVAISNGSACTSQKYEPSHVL
HHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
VAADLPKKQIDGALRFSWSHLTGEVPWDVVAQRLAQLVT
EEECCCHHHHCCEEEEEEHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA