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The map label for this gene is moeA1 [H]

Identifier: 169628182

GI number: 169628182

Start: 1099312

End: 1100619

Strand: Direct

Name: moeA1 [H]

Synonym: MAB_1087

Alternate gene names: 169628182

Gene position: 1099312-1100619 (Clockwise)

Preceding gene: 169628181

Following gene: 169628183

Centisome position: 21.69

GC content: 69.57

Gene sequence:

>1308_bases
GTGCGTTCGGTCGAGGAGCAGCAGGCCAAGGTGACGGCGGCTGCGGTCGCGCCACGCCCGGTTCGGGTGGCGATCGCCGA
AGCCCAGGGTTTGTTGTGCGCCGAGGAAGTAGTGACAGCCCGGCCGTTGCCGGGATTCGACCAAGCCGCCATCGATGGAT
ATGCCGTGCGCAGTGTCGATGTGCAGGCCGCCGGCGGCGTGGTGCGCGTGATCAGTCCGGGCGAGGGCGGCAGCCCCGAT
GACGAGGACGATATTGAGGAATCCGCGGGCGAGATCGGAACGGTCGAGCTACCGGTCGTCGGCACCGTGCGGGTGGGGGA
GCGCACACCGACCCGTCTGCAGCCGCGACAGGCGGTGCGTGTGCAGACCGGGGCCCCCATGCCGACATTGGCGGACGCGG
TGCTGCCGTTGCGCTGGTCCGAGGGGGGCGAGTCGCGCGTCAAGGTGCTGCGCGCGGTGCGTTCGGGTGACTACGTGCGG
CGCACCGGCGACGACGTGCAGCCCGGTGACGTCGCGGTGCGCGCAGGCACCATCATCGGTGCCGCCCAGGTAGGACTGCT
GGCCGCGGTGGGACGCGACCGGGTGCTGGTGCATCCCCGTCCGCGGCTATCGGTGATCAGCGTCGGCGGTGAGCTTGTCG
ACGTCGACCGGACTCCGGGCAATGGCCAGGTGTACGACGTGAATTCCTACGCGCTGGCGGCCGCGGCCCGTGATGCCGGC
GCCGACGTCAACCGCGTGGGCATCGTCAGTGCGGAGCCCGCCGCGTTCCGCGAGGTGGTCGAGGGCCAGCTGAACCGGGC
CGAGGTTGTCGTCATCTCCGGTGCCGTCGGCGGTGCGGCGGCGGAAGGTATTCGTGAGGCACTCTCGGCGCTGGGCGATA
TGGAGGTAGGCCGCATCGCCATGCATCCGGGGTCGGTGCAGGGCTTCGGGCAACTGGGCCGTGACGCGGTGCCCACCTTC
CTGCTCCCGGCCAATCCGGTCGGTGCGCTGGTGGTCTTCGAGGTGATGGTGCGGCCGCTGATTCGGCTGGCATTGGGCCG
TAGGCAGTCGCAACGCCGAATTATTCAGGCGCGCACCGTGTCCCCTATTACTTCCATTGCCGGACGCAAGGGGTTCCTGC
GCGGGCAGCTGATGCGCGATCAGGACAACGGCGAGTATTTGGTGCAGATCCTGGGCGCCCCCGGTGCGTCATCGCATCTG
CTCGCGACGCTGGCTGAGGCGAACTGCCTCGTGATCGTGCCCGCCGAGGTGGAGCAGGTCCGCACGGGCGAGATCGTCGA
GGTCGCGTTCCTGGCGCAGCGCGGATGA

Upstream 100 bases:

>100_bases
TGGATCGCGACGATTACGGTCCGGGCTTGCGGGAGTGGCTGGTCGAGCGGCTCGGCCGGGAATCGTCCGTGCTGCCGGAG
TCGGAGTAAGAAAGGCACCA

Downstream 100 bases:

>100_bases
GCCGCTTGCGCGAAGACCAGGAGCGCGGATGAGCCGCTTGCGCGAAGACCAGGAGCGCGGATGAGCCGCTTGCGCGAAGA
CCAGGAGCGCGCATGAGTGT

Product: molybdopterin biosynthesis protein MoeA1

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAAIDGYAVRSVDVQAAGGVVRVISPGEGGSPD
DEDDIEESAGEIGTVELPVVGTVRVGERTPTRLQPRQAVRVQTGAPMPTLADAVLPLRWSEGGESRVKVLRAVRSGDYVR
RTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPRPRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAG
ADVNRVGIVSAEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIAMHPGSVQGFGQLGRDAVPTF
LLPANPVGALVVFEVMVRPLIRLALGRRQSQRRIIQARTVSPITSIAGRKGFLRGQLMRDQDNGEYLVQILGAPGASSHL
LATLAEANCLVIVPAEVEQVRTGEIVEVAFLAQRG

Sequences:

>Translated_435_residues
MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAAIDGYAVRSVDVQAAGGVVRVISPGEGGSPD
DEDDIEESAGEIGTVELPVVGTVRVGERTPTRLQPRQAVRVQTGAPMPTLADAVLPLRWSEGGESRVKVLRAVRSGDYVR
RTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPRPRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAG
ADVNRVGIVSAEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIAMHPGSVQGFGQLGRDAVPTF
LLPANPVGALVVFEVMVRPLIRLALGRRQSQRRIIQARTVSPITSIAGRKGFLRGQLMRDQDNGEYLVQILGAPGASSHL
LATLAEANCLVIVPAEVEQVRTGEIVEVAFLAQRG
>Mature_435_residues
MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAAIDGYAVRSVDVQAAGGVVRVISPGEGGSPD
DEDDIEESAGEIGTVELPVVGTVRVGERTPTRLQPRQAVRVQTGAPMPTLADAVLPLRWSEGGESRVKVLRAVRSGDYVR
RTGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRDRVLVHPRPRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAG
ADVNRVGIVSAEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIAMHPGSVQGFGQLGRDAVPTF
LLPANPVGALVVFEVMVRPLIRLALGRRQSQRRIIQARTVSPITSIAGRKGFLRGQLMRDQDNGEYLVQILGAPGASSHL
LATLAEANCLVIVPAEVEQVRTGEIVEVAFLAQRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=420, Percent_Identity=28.5714285714286, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI66932975, Length=420, Percent_Identity=28.5714285714286, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1787049, Length=393, Percent_Identity=30.2798982188295, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=379, Percent_Identity=28.2321899736148, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562606, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=24.9382716049383, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=24.9382716049383, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45426; Mature: 45426

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAAIDGYAVRSVD
CCCCHHHHHHEEHHHCCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCHHHCCCEEEEEEE
VQAAGGVVRVISPGEGGSPDDEDDIEESAGEIGTVELPVVGTVRVGERTPTRLQPRQAVR
EEECCCEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECEEEEEEECCCCCCCCCCCCEEE
VQTGAPMPTLADAVLPLRWSEGGESRVKVLRAVRSGDYVRRTGDDVQPGDVAVRAGTIIG
EECCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECEEEC
AAQVGLLAAVGRDRVLVHPRPRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAG
HHHHHHHHHCCCCEEEECCCCCEEEEEECCEEEEECCCCCCCEEEECCCCEEEEHHHCCC
ADVNRVGIVSAEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIA
CCCCEEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEE
MHPGSVQGFGQLGRDAVPTFLLPANPVGALVVFEVMVRPLIRLALGRRQSQRRIIQARTV
ECCCCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
SPITSIAGRKGFLRGQLMRDQDNGEYLVQILGAPGASSHLLATLAEANCLVIVPAEVEQV
CHHHHHHCCCCCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHC
RTGEIVEVAFLAQRG
CCCCEEEEEEEECCC
>Mature Secondary Structure
MRSVEEQQAKVTAAAVAPRPVRVAIAEAQGLLCAEEVVTARPLPGFDQAAIDGYAVRSVD
CCCCHHHHHHEEHHHCCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCHHHCCCEEEEEEE
VQAAGGVVRVISPGEGGSPDDEDDIEESAGEIGTVELPVVGTVRVGERTPTRLQPRQAVR
EEECCCEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECEEEEEEECCCCCCCCCCCCEEE
VQTGAPMPTLADAVLPLRWSEGGESRVKVLRAVRSGDYVRRTGDDVQPGDVAVRAGTIIG
EECCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECEEEC
AAQVGLLAAVGRDRVLVHPRPRLSVISVGGELVDVDRTPGNGQVYDVNSYALAAAARDAG
HHHHHHHHHCCCCEEEECCCCCEEEEEECCEEEEECCCCCCCEEEECCCCEEEEHHHCCC
ADVNRVGIVSAEPAAFREVVEGQLNRAEVVVISGAVGGAAAEGIREALSALGDMEVGRIA
CCCCEEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEE
MHPGSVQGFGQLGRDAVPTFLLPANPVGALVVFEVMVRPLIRLALGRRQSQRRIIQARTV
ECCCCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
SPITSIAGRKGFLRGQLMRDQDNGEYLVQILGAPGASSHLLATLAEANCLVIVPAEVEQV
CHHHHHHCCCCCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHC
RTGEIVEVAFLAQRG
CCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]