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The map label for this gene is mscL [H]

Identifier: 169628177

GI number: 169628177

Start: 1096173

End: 1096568

Strand: Reverse

Name: mscL [H]

Synonym: MAB_1082c

Alternate gene names: 169628177

Gene position: 1096568-1096173 (Counterclockwise)

Preceding gene: 169628178

Following gene: 169628169

Centisome position: 21.64

GC content: 59.09

Gene sequence:

>396_bases
ATGCTTAAGGGATTCAGAGATTTTCTGCTGCGTGGCAACGTCATTGACCTCGCGGTTGCGGTGGTCATCGGAGCGGCCTT
CACCGCGCTGGTCACCAAGTTCAGTGACGCCATTATTCAGCCGTTGATCAATCGGATTGGCACGGGCCCGGATTCGGATC
ACCCTGCGCTCAAGGTCGGCATCGGTGGCGGGCAGTATCTGGACTTCAACGTCCTGGTGACCGCGACCATCAACTTCGTC
CTGATCGCGGCGGTCGTCTACTTCCTGGTTGTGCTGCCGTACAACACGATCAAAGAACGGCTGGCCAAGTCCGGCGAAGA
GCCTGCTGCCCAAACCGAGGCAGAGCTGCTCGTGGAGATTCGCGACCTGCTGGCTGAGCAGAAGAAGGCGTCCTAG

Upstream 100 bases:

>100_bases
AAGGGTGGTAATGGTCGCATTGCCGCCGCAGCAGGCAAATCGTGTCGCCGCAATCGCGCTAGTGCAGGCGGTAACGCTGA
CCTTCCGTTAAGGTCGGATC

Downstream 100 bases:

>100_bases
CGCCTTCTTCTGCTCGTGCCGCCACTACTTCATGTCCCAGGTCTCGCCGTAGGTGGTCACACTGTCCCCGGCGGAACTGA
TCAAACGCGCGTAGGGACGA

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MLKGFRDFLLRGNVIDLAVAVVIGAAFTALVTKFSDAIIQPLINRIGTGPDSDHPALKVGIGGGQYLDFNVLVTATINFV
LIAAVVYFLVVLPYNTIKERLAKSGEEPAAQTEAELLVEIRDLLAEQKKAS

Sequences:

>Translated_131_residues
MLKGFRDFLLRGNVIDLAVAVVIGAAFTALVTKFSDAIIQPLINRIGTGPDSDHPALKVGIGGGQYLDFNVLVTATINFV
LIAAVVYFLVVLPYNTIKERLAKSGEEPAAQTEAELLVEIRDLLAEQKKAS
>Mature_131_residues
MLKGFRDFLLRGNVIDLAVAVVIGAAFTALVTKFSDAIIQPLINRIGTGPDSDHPALKVGIGGGQYLDFNVLVTATINFV
LIAAVVYFLVVLPYNTIKERLAKSGEEPAAQTEAELLVEIRDLLAEQKKAS

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=135, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 14083; Mature: 14083

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGFRDFLLRGNVIDLAVAVVIGAAFTALVTKFSDAIIQPLINRIGTGPDSDHPALKVG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQYLDFNVLVTATINFVLIAAVVYFLVVLPYNTIKERLAKSGEEPAAQTEAELLVEI
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDLLAEQKKAS
HHHHHHHHCCC
>Mature Secondary Structure
MLKGFRDFLLRGNVIDLAVAVVIGAAFTALVTKFSDAIIQPLINRIGTGPDSDHPALKVG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQYLDFNVLVTATINFVLIAAVVYFLVVLPYNTIKERLAKSGEEPAAQTEAELLVEI
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDLLAEQKKAS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA