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The map label for this gene is ethA [H]

Identifier: 169628082

GI number: 169628082

Start: 992076

End: 993587

Strand: Direct

Name: ethA [H]

Synonym: MAB_0985

Alternate gene names: 169628082

Gene position: 992076-993587 (Clockwise)

Preceding gene: 169628077

Following gene: 169628083

Centisome position: 19.58

GC content: 64.02

Gene sequence:

>1512_bases
ATGACCGAACATGTCGACATTGTCATCGTGGGCGCCGGGATCTCGGGTATCGGCATGGCGTGCCGTGTCACCCGTGAGTT
GCCGGGCAAGAAGTTCGTGGTGCTGGAGGCGCGCGAGCGCATCGGCGGCACCTGGGATCTGTTCCGCTACCCGGGTGTGC
GCTCGGATTCGGACATGTTCACGCTCGGCTACAACTTCCGGCCCTGGACGAGCACCAAGGGCATCGCCGACGGCACCTCC
ATCCGCGAGTACGTGACCGAGACTGCGCGCGAGTTCGGTGTGACAGAAAAGGTCCGATTCGGCCACAAGGTCGTCGGCGC
CGAGTGGTCCTCCGAGCGTGGGCTGTGGACGTTGCAGGTCGAGCGTGCGGGAGAGACGGTCGAATTCACCACCCAGTTCC
TGTTGGGCTGCACGGGTTACTACCGCTACGACGAGGGCTTCACGCCCAAGTTCGAGGGCATCGAGGATTTCGCCGGACAG
GTGGTCCACCCGCAGCACTGGCCCGAGGATCTGGACTACTCCGGTAAGAGGGTCGTCGTCATCGGCAGTGGCGCCACGGC
CATGACCCTGGTTCCCGCGATGGCCGGAACGGCAGGTCATGTGACCATGCTGCAGCGTTCGCCCACGTATGTGGTGTCGC
TGCCCTCGACGGATGCGCTCGCCGTGGCGCTGCAGGGCAAGTTGCCTGCCTCGCTCGCGTACCCGATCGTGAAGTGGAAG
AACCAAATGGTCAGCTTCATCAGCTACCAGACAAGCCGTCGCGATCCCGAGCGTATGAAGGGGATCCTGCGCGCGCTGCT
GAAGCGGCAGTTGCCTAACTTCGATCTGGACAAGCACTTCACTCCTAAGTACAACCCGTGGGACCAGCGGCTGTGTGTGG
TGCCGGATTCGGACCTGTTCCGCGCGCTGCGCAAGGGCACCGCGTCCATCGTGACCGATCGGATCACGCGCTTCACGCCG
AAGGGCATCCTGCTCGAGTCCGGTGAAGAGCTCGAGGCCGACATCGTGGTCACCGCCACCGGCTTGAACGTTCAGCTGGC
CGGGGGACTGCGGCCGATCGTGGACGGTGTCCAGCTGAATCCCGCAGATTCGGTGAGCTACAAGGGTCTGATGCTGACCG
GCCTGCCGAACTTCATCTTCACGTTCGGGTACACCAATGCCTCCTGGACGCTGCGCGCCGACCTGGTGTCGCAGTACACC
TGCCGGCTGCTCAAATACATGGACAAGGAAGGGCAGACGGTGGTGTGGCCGGTCGAGCCGGACACCGCCGAGCGGCTGCC
GTTCTTGGAGGACTTGGTCTCCGGATACGTCACGCGCGCGGAGAACGCGATGCCGCACCAGGTGCCGCTGGCCCCGTGGC
GCTCCTATCAGAATTACTTCCGCGAGCTGCCGGTGCTCAAGTACGGCAAGGTCGCGGACAAGGGTGTCCGTTTCAGTTCC
GGAGCCGCAGGGTCGGCGACGTCCGGCAGGGGAAATGCTTCGCACGAGGCCCCCGTTGCAATAGGCAGGTAA

Upstream 100 bases:

>100_bases
CGGCCTCTCGTAGCCGGTTTTGTCACGTCTACCTGCGCATTCTTTAAAGTTATCGACACACTGTTGACTTTCTCAACACT
GCGTCGATAGCCTAGCTGTC

Downstream 100 bases:

>100_bases
ATACCTGCATAATGGCCGGGTGCAGTCAGCACCCGGCCATTCTCATTGGGACGTGGTTTTCAAGGCTCTCGCCGATCCCA
CGCGGCGCGAGTTACTAGAC

Product: putative monooxygenase EthA

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTEHVDIVIVGAGISGIGMACRVTRELPGKKFVVLEARERIGGTWDLFRYPGVRSDSDMFTLGYNFRPWTSTKGIADGTS
IREYVTETAREFGVTEKVRFGHKVVGAEWSSERGLWTLQVERAGETVEFTTQFLLGCTGYYRYDEGFTPKFEGIEDFAGQ
VVHPQHWPEDLDYSGKRVVVIGSGATAMTLVPAMAGTAGHVTMLQRSPTYVVSLPSTDALAVALQGKLPASLAYPIVKWK
NQMVSFISYQTSRRDPERMKGILRALLKRQLPNFDLDKHFTPKYNPWDQRLCVVPDSDLFRALRKGTASIVTDRITRFTP
KGILLESGEELEADIVVTATGLNVQLAGGLRPIVDGVQLNPADSVSYKGLMLTGLPNFIFTFGYTNASWTLRADLVSQYT
CRLLKYMDKEGQTVVWPVEPDTAERLPFLEDLVSGYVTRAENAMPHQVPLAPWRSYQNYFRELPVLKYGKVADKGVRFSS
GAAGSATSGRGNASHEAPVAIGR

Sequences:

>Translated_503_residues
MTEHVDIVIVGAGISGIGMACRVTRELPGKKFVVLEARERIGGTWDLFRYPGVRSDSDMFTLGYNFRPWTSTKGIADGTS
IREYVTETAREFGVTEKVRFGHKVVGAEWSSERGLWTLQVERAGETVEFTTQFLLGCTGYYRYDEGFTPKFEGIEDFAGQ
VVHPQHWPEDLDYSGKRVVVIGSGATAMTLVPAMAGTAGHVTMLQRSPTYVVSLPSTDALAVALQGKLPASLAYPIVKWK
NQMVSFISYQTSRRDPERMKGILRALLKRQLPNFDLDKHFTPKYNPWDQRLCVVPDSDLFRALRKGTASIVTDRITRFTP
KGILLESGEELEADIVVTATGLNVQLAGGLRPIVDGVQLNPADSVSYKGLMLTGLPNFIFTFGYTNASWTLRADLVSQYT
CRLLKYMDKEGQTVVWPVEPDTAERLPFLEDLVSGYVTRAENAMPHQVPLAPWRSYQNYFRELPVLKYGKVADKGVRFSS
GAAGSATSGRGNASHEAPVAIGR
>Mature_502_residues
TEHVDIVIVGAGISGIGMACRVTRELPGKKFVVLEARERIGGTWDLFRYPGVRSDSDMFTLGYNFRPWTSTKGIADGTSI
REYVTETAREFGVTEKVRFGHKVVGAEWSSERGLWTLQVERAGETVEFTTQFLLGCTGYYRYDEGFTPKFEGIEDFAGQV
VHPQHWPEDLDYSGKRVVVIGSGATAMTLVPAMAGTAGHVTMLQRSPTYVVSLPSTDALAVALQGKLPASLAYPIVKWKN
QMVSFISYQTSRRDPERMKGILRALLKRQLPNFDLDKHFTPKYNPWDQRLCVVPDSDLFRALRKGTASIVTDRITRFTPK
GILLESGEELEADIVVTATGLNVQLAGGLRPIVDGVQLNPADSVSYKGLMLTGLPNFIFTFGYTNASWTLRADLVSQYTC
RLLKYMDKEGQTVVWPVEPDTAERLPFLEDLVSGYVTRAENAMPHQVPLAPWRSYQNYFRELPVLKYGKVADKGVRFSSG
AAGSATSGRGNASHEAPVAIGR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=220, Percent_Identity=24.0909090909091, Blast_Score=66, Evalue=1e-10,
Organism=Homo sapiens, GI50541961, Length=220, Percent_Identity=24.0909090909091, Blast_Score=66, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI25145785, Length=388, Percent_Identity=24.4845360824742, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI193202226, Length=229, Percent_Identity=24.8908296943231, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55731; Mature: 55600

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHVDIVIVGAGISGIGMACRVTRELPGKKFVVLEARERIGGTWDLFRYPGVRSDSDMF
CCCEEEEEEEECCCCCCCCEEEEHHCCCCCEEEEEEEHHHCCCEEEHHCCCCCCCCCCEE
TLGYNFRPWTSTKGIADGTSIREYVTETAREFGVTEKVRFGHKVVGAEWSSERGLWTLQV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCCEEEEEE
ERAGETVEFTTQFLLGCTGYYRYDEGFTPKFEGIEDFAGQVVHPQHWPEDLDYSGKRVVV
ECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEE
IGSGATAMTLVPAMAGTAGHVTMLQRSPTYVVSLPSTDALAVALQGKLPASLAYPIVKWK
EECCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHH
NQMVSFISYQTSRRDPERMKGILRALLKRQLPNFDLDKHFTPKYNPWDQRLCVVPDSDLF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
RALRKGTASIVTDRITRFTPKGILLESGEELEADIVVTATGLNVQLAGGLRPIVDGVQLN
HHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCEEEECCCCHHHHCCCCCC
PADSVSYKGLMLTGLPNFIFTFGYTNASWTLRADLVSQYTCRLLKYMDKEGQTVVWPVEP
CCCCCCCCCEEEECCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCC
DTAERLPFLEDLVSGYVTRAENAMPHQVPLAPWRSYQNYFRELPVLKYGKVADKGVRFSS
CHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCEECC
GAAGSATSGRGNASHEAPVAIGR
CCCCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
TEHVDIVIVGAGISGIGMACRVTRELPGKKFVVLEARERIGGTWDLFRYPGVRSDSDMF
CCEEEEEEEECCCCCCCCEEEEHHCCCCCEEEEEEEHHHCCCEEEHHCCCCCCCCCCEE
TLGYNFRPWTSTKGIADGTSIREYVTETAREFGVTEKVRFGHKVVGAEWSSERGLWTLQV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCCCCEEEEEE
ERAGETVEFTTQFLLGCTGYYRYDEGFTPKFEGIEDFAGQVVHPQHWPEDLDYSGKRVVV
ECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEE
IGSGATAMTLVPAMAGTAGHVTMLQRSPTYVVSLPSTDALAVALQGKLPASLAYPIVKWK
EECCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHH
NQMVSFISYQTSRRDPERMKGILRALLKRQLPNFDLDKHFTPKYNPWDQRLCVVPDSDLF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
RALRKGTASIVTDRITRFTPKGILLESGEELEADIVVTATGLNVQLAGGLRPIVDGVQLN
HHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCEEEECCCCHHHHCCCCCC
PADSVSYKGLMLTGLPNFIFTFGYTNASWTLRADLVSQYTCRLLKYMDKEGQTVVWPVEP
CCCCCCCCCEEEECCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCC
DTAERLPFLEDLVSGYVTRAENAMPHQVPLAPWRSYQNYFRELPVLKYGKVADKGVRFSS
CHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCEECC
GAAGSATSGRGNASHEAPVAIGR
CCCCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]