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The map label for this gene is echA6 [H]

Identifier: 169628056

GI number: 169628056

Start: 966667

End: 967398

Strand: Direct

Name: echA6 [H]

Synonym: MAB_0959

Alternate gene names: 169628056

Gene position: 966667-967398 (Clockwise)

Preceding gene: 169628054

Following gene: 169628057

Centisome position: 19.08

GC content: 66.67

Gene sequence:

>732_bases
ATGATCGGTGTAACTAGCGACGGTCCCGTCACCACCATTGAGCTGCAGCGCCCGGAGCGGCGTAACGCGGTGACCTATGA
GCTCGCGCTCGCCTTCGCCGAGGAGGTCAAGAAGGCCGCGGAAACCGCACGTGCGATCGTCGTCACGGGGCAGGGCACGT
CGTTCTGCGCCGGCGCCGACCTGTCCAGCGGCGCTCCTGATCCCGACAAATTCGCCGATGCGTGGCAGCACTCGATCAAG
AGTGTCGATGCGGCCGACATCCCGGTCATCGCCGCCGTCAACGGCCCCGCGATCGGCGCGGGCGTCATGCTGGCAATGGT
CGCCGATCTGCGGGTGGTCTCCGAGACCGCGCGTTTCCAGTTCCCCGTCGCCAAATATGGCATCGCCCTTGATAACTGGA
GTATCCGTCGGCTGACCTCGCTGGTGGGCTACGGGCGCGCGCGTGCCATGCTGCTGGCCGCCGAGCCGCTTGACGCGCAG
ACGGCATTGCAGACCGGCATGGCCAACCGCATCGGCGAACTCGCCGATGCGCAGGCCTGGGCGGCCGAGCTCGCCGGGTT
CGCACCACTTGCTCTCAAGCACGCCAAGCGCGTGCTCAATGACGACGGCGCCTTCGAGGACCAGTGGCCCGAGCACAAGG
AACTGTTCGACAAGGCGTGGGGCAGCCAGGACATCATCGAGGCCCAGGTCGCCCGAATTCAGAAGCGTCCCCCCAACTTC
CAGGGAGCCTGA

Upstream 100 bases:

>100_bases
CCAGACCGCGCCGGCGTAGGAAGTATCCCGCCGCGATCCCGGCCTGCCCGCCACCAATCACGGCGACGGTAGTCATGGGC
GCCATATTAGGGTGGTTGCC

Downstream 100 bases:

>100_bases
GCGTGCGGGCGCTCTGGGTTGGTGCCGGCGCAGCCATTGCGTCGACGTGGATCGGGCGCGCCCTGCGTGATGTCCCGCAG
ACGCTGGGTGCCAGCAAGGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGADLSSGAPDPDKFADAWQHSIK
SVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQFPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQ
TALQTGMANRIGELADAQAWAAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNF
QGA

Sequences:

>Translated_243_residues
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGADLSSGAPDPDKFADAWQHSIK
SVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQFPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQ
TALQTGMANRIGELADAQAWAAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNF
QGA
>Mature_243_residues
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGADLSSGAPDPDKFADAWQHSIK
SVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQFPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQ
TALQTGMANRIGELADAQAWAAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNF
QGA

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=31.8725099601594, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI221136756, Length=216, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI221136753, Length=216, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI221307494, Length=216, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI25453481, Length=249, Percent_Identity=23.6947791164659, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=249, Percent_Identity=23.6947791164659, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=210, Percent_Identity=30, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4757966, Length=239, Percent_Identity=24.2677824267782, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI51538581, Length=239, Percent_Identity=24.2677824267782, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4757968, Length=249, Percent_Identity=23.2931726907631, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI49355787, Length=249, Percent_Identity=23.2931726907631, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=32.9317269076305, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=30.2325581395349, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082183, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788597, Length=255, Percent_Identity=28.2352941176471, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787660, Length=252, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=230, Percent_Identity=31.304347826087, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17536985, Length=273, Percent_Identity=25.2747252747253, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=29.6442687747036, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=31.1475409836066, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=204, Percent_Identity=27.4509803921569, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=255, Percent_Identity=24.7058823529412, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357171, Length=215, Percent_Identity=30.6976744186047, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19920382, Length=223, Percent_Identity=31.390134529148, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=28.9156626506024, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=28.9156626506024, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24654903, Length=215, Percent_Identity=29.3023255813954, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650670, Length=214, Percent_Identity=27.1028037383178, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 25954; Mature: 25954

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGAD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECCCC
LSSGAPDPDKFADAWQHSIKSVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQ
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
FPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQTALQTGMANRIGELADAQAW
CCHHHHCEEECCCHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNF
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC
>Mature Secondary Structure
MIGVTSDGPVTTIELQRPERRNAVTYELALAFAEEVKKAAETARAIVVTGQGTSFCAGAD
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECCCC
LSSGAPDPDKFADAWQHSIKSVDAADIPVIAAVNGPAIGAGVMLAMVADLRVVSETARFQ
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
FPVAKYGIALDNWSIRRLTSLVGYGRARAMLLAAEPLDAQTALQTGMANRIGELADAQAW
CCHHHHCEEECCCHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AAELAGFAPLALKHAKRVLNDDGAFEDQWPEHKELFDKAWGSQDIIEAQVARIQKRPPNF
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]