Click here to switch to the map view.

The map label for this gene is prrB [H]

Identifier: 169628052

GI number: 169628052

Start: 962707

End: 964119

Strand: Reverse

Name: prrB [H]

Synonym: MAB_0955c

Alternate gene names: 169628052

Gene position: 964119-962707 (Counterclockwise)

Preceding gene: 169628053

Following gene: 169628047

Centisome position: 19.03

GC content: 63.98

Gene sequence:

>1413_bases
ATGAGCACCTCGCACGAGAACCCGCCAGTCATGGGCCGCCCCAGCAAGCACCGCAGTCAACGGATCACCGATCTGTCCTA
CCGGTTATTGGAGAAGCCCATGCGGATCTTCTCGCTGCGCACCCTGGTCGCCATCGCCGCGCTGGGCGTGATGGTGCTGG
TGGTGACACTGGGCACCTGGGTGTGGCTGGGCGTCGAGGAAGACCAGTACAGCCAGCTGGATCGGCGCCTTGATTCGGTG
TCCAGCCTCGGTGCCGTGTCGAATCTGCTGAATTCGGTGATCAGCTCCGACAAGAAACTCGACACCCCCGACGGCCTGGT
GCTCACCGCCCGCGTGGCCGGCCTCACCAAATCCATCCCTACCGACACCGAGCTTCCGCTGTTGGAGCCGGGCTACGCCA
ACACCAAGATCAATGGTGTCGAATACCGCGTCCGGTCGTTCATCGCCCCGGGAAACATCCCCGTGGCGGTGGGAGCCCCG
GTCGCCGAGACACAACGCCAGATCGACCGGTACCACATGCGCATCCTGGCGATCTGCGGCGGCGTGCTGATCGGCACCGT
GATCGTCGGCTGGGTCATCTCGCTCATCGTGGTAAGCCCGTTCCGGCTGCTGGCGCAGCAGGCCCGTCTGATCAACGCAC
AGTCCAACCCCGATGACGTGAACGTTCGCGGTGTACGTGAGGCCGTCGAGATCTCCGAGGCCGTCGAAGGGATGCTCGAG
CGCATCAACACCGAACAGGAAAAGACCAAGGCCGCACTGGAATCCGCACGTGATTTCGCGGCCGTCGCCTCACACGAGCT
GCGCACCCCGCTCACCGCGATGCGGACCAATCTCGAAGTGCTCTCCACCCTCAATCTCAGCGATGACCAACGCGAAGAAA
TCATCGAGGAGACCATACGGACCCAAAGCAGGGTCGAGGCAACACTTTCCGCACTGGAGCGGCTGGCGCAGGGCCAGCTC
ACCACCGAGGACGACCACGTGCCCGTCGACATCACCGAGTTGTTGGACCGCGCCGCGCACGACGCGGATCGCAGCTATCC
GAATCTTGAGATTTCGCTGGTGCCGTCGTCCACGATTCTGATGCTCGGGTTGCCCGCTGGGCTACGGCTGGTGATCGACA
ACGCGATCAAGAACGCGGTGAAGCACGGCGGTGCGAGCAAGATTCAGCTCTCGGCGACCAGCACGGTACACGGGGTAGAA
ATCGCGGTCGATGACAACGGCAGCGGCATCCCAGAGGCCGAGCGGGTGCAGGTGTTCGAGCGATTTTCACGAGGCTCCAC
CGCCTCGCATTCGGGCTCCGGGCTGGGCCTGGCACTGGTGGCACAGCAGGCCGAACTCCATGGCGGCACAGCTGCTTTGG
AGTCGAGCCCATTGGGAGGCGCACGGCTGGTGCTGCGCCTCCCCGGGCATTGA

Upstream 100 bases:

>100_bases
CATCGGTTACCTGCGCCGCAAGCTGGAGGCCGGCGGTGCACCCCGGCTGTTGCACACCGTGCGCGGTGTCGGGTTCGTGC
TGCGTTCGCAGTAGCGACGG

Downstream 100 bases:

>100_bases
TCCTGGCGAAGCCCTAGCGGGCGCCGAGCAGGTCGATCACGAATACCAGCGTCTTACCCGACAGCTGGTGGCCGGCACCG
GCCTCGCCGTAGGCCTGCGC

Product: sensor histidine kinase PrrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSTSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRTLVAIAALGVMVLVVTLGTWVWLGVEEDQYSQLDRRLDSV
SSLGAVSNLLNSVISSDKKLDTPDGLVLTARVAGLTKSIPTDTELPLLEPGYANTKINGVEYRVRSFIAPGNIPVAVGAP
VAETQRQIDRYHMRILAICGGVLIGTVIVGWVISLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLE
RINTEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEIIEETIRTQSRVEATLSALERLAQGQL
TTEDDHVPVDITELLDRAAHDADRSYPNLEISLVPSSTILMLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATSTVHGVE
IAVDDNGSGIPEAERVQVFERFSRGSTASHSGSGLGLALVAQQAELHGGTAALESSPLGGARLVLRLPGH

Sequences:

>Translated_470_residues
MSTSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRTLVAIAALGVMVLVVTLGTWVWLGVEEDQYSQLDRRLDSV
SSLGAVSNLLNSVISSDKKLDTPDGLVLTARVAGLTKSIPTDTELPLLEPGYANTKINGVEYRVRSFIAPGNIPVAVGAP
VAETQRQIDRYHMRILAICGGVLIGTVIVGWVISLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLE
RINTEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEIIEETIRTQSRVEATLSALERLAQGQL
TTEDDHVPVDITELLDRAAHDADRSYPNLEISLVPSSTILMLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATSTVHGVE
IAVDDNGSGIPEAERVQVFERFSRGSTASHSGSGLGLALVAQQAELHGGTAALESSPLGGARLVLRLPGH
>Mature_469_residues
STSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRTLVAIAALGVMVLVVTLGTWVWLGVEEDQYSQLDRRLDSVS
SLGAVSNLLNSVISSDKKLDTPDGLVLTARVAGLTKSIPTDTELPLLEPGYANTKINGVEYRVRSFIAPGNIPVAVGAPV
AETQRQIDRYHMRILAICGGVLIGTVIVGWVISLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLER
INTEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEIIEETIRTQSRVEATLSALERLAQGQLT
TEDDHVPVDITELLDRAAHDADRSYPNLEISLVPSSTILMLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATSTVHGVEI
AVDDNGSGIPEAERVQVFERFSRGSTASHSGSGLGLALVAQQAELHGGTAALESSPLGGARLVLRLPGH

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=31.3304721030043, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=30.1204819277108, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788713, Length=282, Percent_Identity=28.0141843971631, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=32.4561403508772, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=29.9107142857143, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=356, Percent_Identity=25, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=25.9842519685039, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=330, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=367, Percent_Identity=23.1607629427793, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=256, Percent_Identity=27.734375, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=28.3400809716599, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=305, Percent_Identity=27.2131147540984, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789808, Length=212, Percent_Identity=27.8301886792453, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082128, Length=243, Percent_Identity=27.9835390946502, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50649; Mature: 50518

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRTLVAIAALGVMVLVVTLGTW
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWLGVEEDQYSQLDRRLDSVSSLGAVSNLLNSVISSDKKLDTPDGLVLTARVAGLTKSIP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCCC
TDTELPLLEPGYANTKINGVEYRVRSFIAPGNIPVAVGAPVAETQRQIDRYHMRILAICG
CCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
GVLIGTVIVGWVISLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RINTEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEIIEETIR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQSRVEATLSALERLAQGQLTTEDDHVPVDITELLDRAAHDADRSYPNLEISLVPSSTIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEE
MLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATSTVHGVEIAVDDNGSGIPEAERVQVFE
EEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEEEECCCCCCCCHHHHHHHHH
RFSRGSTASHSGSGLGLALVAQQAELHGGTAALESSPLGGARLVLRLPGH
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
STSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRTLVAIAALGVMVLVVTLGTW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWLGVEEDQYSQLDRRLDSVSSLGAVSNLLNSVISSDKKLDTPDGLVLTARVAGLTKSIP
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCCC
TDTELPLLEPGYANTKINGVEYRVRSFIAPGNIPVAVGAPVAETQRQIDRYHMRILAICG
CCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
GVLIGTVIVGWVISLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RINTEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEIIEETIR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQSRVEATLSALERLAQGQLTTEDDHVPVDITELLDRAAHDADRSYPNLEISLVPSSTIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEE
MLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATSTVHGVEIAVDDNGSGIPEAERVQVFE
EEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEEEECCCCCCCCHHHHHHHHH
RFSRGSTASHSGSGLGLALVAQQAELHGGTAALESSPLGGARLVLRLPGH
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]