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The map label for this gene is tetR [H]

Identifier: 169627955

GI number: 169627955

Start: 855165

End: 855833

Strand: Reverse

Name: tetR [H]

Synonym: MAB_0856c

Alternate gene names: 169627955

Gene position: 855833-855165 (Counterclockwise)

Preceding gene: 169627959

Following gene: 169627948

Centisome position: 16.89

GC content: 62.48

Gene sequence:

>669_bases
GTGATTTTGAATCGAGAGACGATCGCACGCGCCGGACTGGCCCTGCTGGACGAGAAGGGCAGCGACGGACTGACCATGCG
CGCACTCGCCGCCTCACTCGGCGTCCAGGCGCCAGCCCTCTACTGGCATGTGAAGAACCGCCGAGAACTCATCGACCTCA
TGGGCGAGGTGATCGTTCAAGAGGCCTACGAATCCTTCGATCTCTCGACCGCACCCTGGGATGTTTTCCTGGCCAACGGA
GCTCGCGCATTTCGGCAGGCAATGCTGCGGTACCACCAGGGCGCCCGGATACTCGCCGGCACCTTTGCGACCAATGCCGC
CGACATGGTGGAGCCGCTGCTGGACGCCATGACGTCGGCGGGCTTCACCGTTCGCGAAGCCGCTCGATTATCACCCGCTA
TCTACCACTACACAATCGGTTTCACGATTGAGCAGCAGTCCCGGGACGGCTCCGAGTACCCGGGGCCCAACCCGTACACC
GAAGAGAATCTGCTGGCCAAGCTCGACCTGCACAAGTATCCCGCGGTCGCGGAGGCCTTCTCGGAGATCTACGACCCCGA
CTTCGATGCCGATTTCGAAGATGGGCTGACGATCATCATCGACGGCCTGCGAGCTCGACTTCACGCGAAGCGGAAATCAG
CGGCTCCTCGGGTGACGACTCGCCGCTAG

Upstream 100 bases:

>100_bases
CCTGCGCCCGCGACAACAACCGCATGCTCAGCCATAACACTCCTTAACATCGTTATCGGCATTAACACCATAATGTCTTT
AACGATGTTAAAGTGTCAAC

Downstream 100 bases:

>100_bases
CAGCCTCGGGATCGTCCGAGACGGCGCAATCCCCTTCCTGCGCGTCCGGCTTCGAACGCGAGAAGCGCTGGCGGAACCAT
GATTCCACGCTCGCCGAGGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MILNRETIARAGLALLDEKGSDGLTMRALAASLGVQAPALYWHVKNRRELIDLMGEVIVQEAYESFDLSTAPWDVFLANG
ARAFRQAMLRYHQGARILAGTFATNAADMVEPLLDAMTSAGFTVREAARLSPAIYHYTIGFTIEQQSRDGSEYPGPNPYT
EENLLAKLDLHKYPAVAEAFSEIYDPDFDADFEDGLTIIIDGLRARLHAKRKSAAPRVTTRR

Sequences:

>Translated_222_residues
MILNRETIARAGLALLDEKGSDGLTMRALAASLGVQAPALYWHVKNRRELIDLMGEVIVQEAYESFDLSTAPWDVFLANG
ARAFRQAMLRYHQGARILAGTFATNAADMVEPLLDAMTSAGFTVREAARLSPAIYHYTIGFTIEQQSRDGSEYPGPNPYT
EENLLAKLDLHKYPAVAEAFSEIYDPDFDADFEDGLTIIIDGLRARLHAKRKSAAPRVTTRR
>Mature_222_residues
MILNRETIARAGLALLDEKGSDGLTMRALAASLGVQAPALYWHVKNRRELIDLMGEVIVQEAYESFDLSTAPWDVFLANG
ARAFRQAMLRYHQGARILAGTFATNAADMVEPLLDAMTSAGFTVREAARLSPAIYHYTIGFTIEQQSRDGSEYPGPNPYT
EENLLAKLDLHKYPAVAEAFSEIYDPDFDADFEDGLTIIIDGLRARLHAKRKSAAPRVTTRR

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24620; Mature: 24620

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILNRETIARAGLALLDEKGSDGLTMRALAASLGVQAPALYWHVKNRRELIDLMGEVIVQ
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHH
EAYESFDLSTAPWDVFLANGARAFRQAMLRYHQGARILAGTFATNAADMVEPLLDAMTSA
HHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHC
GFTVREAARLSPAIYHYTIGFTIEQQSRDGSEYPGPNPYTEENLLAKLDLHKYPAVAEAF
CCHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
SEIYDPDFDADFEDGLTIIIDGLRARLHAKRKSAAPRVTTRR
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MILNRETIARAGLALLDEKGSDGLTMRALAASLGVQAPALYWHVKNRRELIDLMGEVIVQ
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHH
EAYESFDLSTAPWDVFLANGARAFRQAMLRYHQGARILAGTFATNAADMVEPLLDAMTSA
HHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHC
GFTVREAARLSPAIYHYTIGFTIEQQSRDGSEYPGPNPYTEENLLAKLDLHKYPAVAEAF
CCHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
SEIYDPDFDADFEDGLTIIIDGLRARLHAKRKSAAPRVTTRR
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6093049; 8153629; 9642048; 9890898; 9878420 [H]