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The map label for this gene is gabT [H]

Identifier: 169627920

GI number: 169627920

Start: 815549

End: 816907

Strand: Direct

Name: gabT [H]

Synonym: MAB_0821

Alternate gene names: 169627920

Gene position: 815549-816907 (Clockwise)

Preceding gene: 169627918

Following gene: 169627921

Centisome position: 16.09

GC content: 66.74

Gene sequence:

>1359_bases
ATGACCTCGGTGTATAGCCTCCAGGGAGGGCCGGCAGTGGCCCAGGTGCGACGAATGGCGACGGAAGTGCCTGGGCCACG
CTCGCGCGAGCTCGCCGAGCGCCGCGCAGCGGCGTTGCCAGCCGGCCTGGTCAGCGGTGCCGGTGTGTATGCCGCCGCGG
CGGGCGGCGGCGTACTGGTCGATGTCGACGGCAACAGCTTTCTGGATCTGGGCAGCGGCATTGCCGTCACCACGGTGGGC
AACAGCGCACCTGCGGTGGTTGCCCGTGTGGCCGCGCAGGCTCAACGGTTCACCCACACATGCTTTCTGGCGACGCCCTA
CGAGCAGTACCTGGAGGTCGCCGAGACACTCAACCGAATCACTCCCGGGGACCACGAGAAGCGCACCGCGCTGTTCAACA
CCGGTGCCGAAGCGGTTGAGAACGCGGTCAAGTACGCCCGGGTGGCGACGGCCCGCCCGGCGGTGGTTGTTTTCGATCAT
GCCTTCCATGGCCGGTCGCTGATGACCATGACCATGACCGCCAAACAGGCTCCGTACCGTCGGGGTTTCGGGCCGTTCGC
TCCGGAGGTGTACCGGGCACCCATGGCCCACCCCTATCGGTGGCCGTCCGGAGCCGAGAACTGCGCCTCGGACGCGTTCC
GCCAGTTCGCGTCCCTGGTCGACAACCAGATCGGTGCCGAAGCGGTGGCCTGTGTGGTGGTGGAGCCGATCCAGGGCGAG
GGCGGCTTTATCGTCCCGGCGCCCGGATTCTTGGCGATGGTTGCCGACTTCTGCCGGGCGCGTGGCATCCTGTTGGTCGC
CGACGAAGTCCAAACCGGTATTGCCCGGACCGGTGCATGGTTCGCCTCCGAGCACGAACAGCTGGTACCCGACCTCGTCA
CCACCGCGAAGGGGCTTGCGGGCGGACTGCCTCTGGCTGCGGTAACCGGCCGCGCCGACGTCATGGACGCCGCGCATCCG
GGTGGTATCGGTGGAACCTTCAGTGGCAACCCGCTTTCCTGTGCGGCGGCACTCGGCGTCTTCGAAGAGATCGAGACCCA
CGACCTGCTCAGGCGTGCCGCCGATATGGGCGAGATGTTGCTTCGGGAGATGCGTGGCATCTCCGCGGAGACCGGCCTGA
TCGGAGACATCCGTGGGCGCGGCGCGATGATCGCTGCCGAGCTGGTGGTGCCGGGCACCGACTCGCCGAATCGTGAAGCG
GTGATACAGATCTTGAAGTATTGCCAGGACAACGGTGTGCTGGTGCTTTCTGCTGGAACGTACGGCAATGTGCTGCGATT
CCTGCCGCCGCTGTCCATGCCGGACGAGCTGCTGCAAGAGGCCCTCGCCGTGCTGCGCGACGCGTTCCGGAACCTCTAA

Upstream 100 bases:

>100_bases
AAAAAGGCCATGAAACATATATGACTTGTCCAATTCGGATATTCCTGTCCACCGTGTTCCGCTCCTACGCTCGGGGTGAC
TTTGAGCGGAAGGAAAGCTG

Downstream 100 bases:

>100_bases
AGACGTTGCGAATAGACCAGACCCAAGGAGTTTCGATATGTCCACTGCAGTAACCCCGTCGCCGGAGATGTGCTCGACCC
CGCTGGAGCTGTTCGACACA

Product: 4-aminobutyrate aminotransferase GabT

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTSVYSLQGGPAVAQVRRMATEVPGPRSRELAERRAAALPAGLVSGAGVYAAAAGGGVLVDVDGNSFLDLGSGIAVTTVG
NSAPAVVARVAAQAQRFTHTCFLATPYEQYLEVAETLNRITPGDHEKRTALFNTGAEAVENAVKYARVATARPAVVVFDH
AFHGRSLMTMTMTAKQAPYRRGFGPFAPEVYRAPMAHPYRWPSGAENCASDAFRQFASLVDNQIGAEAVACVVVEPIQGE
GGFIVPAPGFLAMVADFCRARGILLVADEVQTGIARTGAWFASEHEQLVPDLVTTAKGLAGGLPLAAVTGRADVMDAAHP
GGIGGTFSGNPLSCAAALGVFEEIETHDLLRRAADMGEMLLREMRGISAETGLIGDIRGRGAMIAAELVVPGTDSPNREA
VIQILKYCQDNGVLVLSAGTYGNVLRFLPPLSMPDELLQEALAVLRDAFRNL

Sequences:

>Translated_452_residues
MTSVYSLQGGPAVAQVRRMATEVPGPRSRELAERRAAALPAGLVSGAGVYAAAAGGGVLVDVDGNSFLDLGSGIAVTTVG
NSAPAVVARVAAQAQRFTHTCFLATPYEQYLEVAETLNRITPGDHEKRTALFNTGAEAVENAVKYARVATARPAVVVFDH
AFHGRSLMTMTMTAKQAPYRRGFGPFAPEVYRAPMAHPYRWPSGAENCASDAFRQFASLVDNQIGAEAVACVVVEPIQGE
GGFIVPAPGFLAMVADFCRARGILLVADEVQTGIARTGAWFASEHEQLVPDLVTTAKGLAGGLPLAAVTGRADVMDAAHP
GGIGGTFSGNPLSCAAALGVFEEIETHDLLRRAADMGEMLLREMRGISAETGLIGDIRGRGAMIAAELVVPGTDSPNREA
VIQILKYCQDNGVLVLSAGTYGNVLRFLPPLSMPDELLQEALAVLRDAFRNL
>Mature_451_residues
TSVYSLQGGPAVAQVRRMATEVPGPRSRELAERRAAALPAGLVSGAGVYAAAAGGGVLVDVDGNSFLDLGSGIAVTTVGN
SAPAVVARVAAQAQRFTHTCFLATPYEQYLEVAETLNRITPGDHEKRTALFNTGAEAVENAVKYARVATARPAVVVFDHA
FHGRSLMTMTMTAKQAPYRRGFGPFAPEVYRAPMAHPYRWPSGAENCASDAFRQFASLVDNQIGAEAVACVVVEPIQGEG
GFIVPAPGFLAMVADFCRARGILLVADEVQTGIARTGAWFASEHEQLVPDLVTTAKGLAGGLPLAAVTGRADVMDAAHPG
GIGGTFSGNPLSCAAALGVFEEIETHDLLRRAADMGEMLLREMRGISAETGLIGDIRGRGAMIAAELVVPGTDSPNREAV
IQILKYCQDNGVLVLSAGTYGNVLRFLPPLSMPDELLQEALAVLRDAFRNL

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=30.1587301587302, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI13994255, Length=416, Percent_Identity=31.9711538461538, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=32.7160493827161, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=29.6116504854369, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=29.126213592233, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI24119277, Length=405, Percent_Identity=29.1358024691358, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=29.5918367346939, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI188536080, Length=466, Percent_Identity=27.0386266094421, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38679950, Length=466, Percent_Identity=27.0386266094421, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38679946, Length=466, Percent_Identity=27.0386266094421, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=43.0260047281324, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=42.5882352941177, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=32.994923857868, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI145693181, Length=420, Percent_Identity=33.5714285714286, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=32.5699745547074, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=28.0871670702179, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786349, Length=306, Percent_Identity=30.718954248366, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=443, Percent_Identity=28.4424379232506, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=30.2380952380952, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=410, Percent_Identity=30.4878048780488, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=321, Percent_Identity=29.9065420560748, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17541228, Length=477, Percent_Identity=25.9958071278826, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=29.8507462686567, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=29.9019607843137, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321456, Length=422, Percent_Identity=25.5924170616114, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=395, Percent_Identity=22.2784810126582, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161085790, Length=420, Percent_Identity=32.1428571428571, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21357415, Length=446, Percent_Identity=28.2511210762332, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574759, Length=404, Percent_Identity=32.1782178217822, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI21356575, Length=431, Percent_Identity=30.8584686774942, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI281366494, Length=444, Percent_Identity=25.9009009009009, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667139, Length=444, Percent_Identity=25.9009009009009, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667143, Length=444, Percent_Identity=25.9009009009009, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 47474; Mature: 47343

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVYSLQGGPAVAQVRRMATEVPGPRSRELAERRAAALPAGLVSGAGVYAAAAGGGVLV
CCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEEE
DVDGNSFLDLGSGIAVTTVGNSAPAVVARVAAQAQRFTHTCFLATPYEQYLEVAETLNRI
EECCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHC
TPGDHEKRTALFNTGAEAVENAVKYARVATARPAVVVFDHAFHGRSLMTMTMTAKQAPYR
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEHHHHCCCC
RGFGPFAPEVYRAPMAHPYRWPSGAENCASDAFRQFASLVDNQIGAEAVACVVVEPIQGE
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEECCC
GGFIVPAPGFLAMVADFCRARGILLVADEVQTGIARTGAWFASEHEQLVPDLVTTAKGLA
CCEEECCCHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
GGLPLAAVTGRADVMDAAHPGGIGGTFSGNPLSCAAALGVFEEIETHDLLRRAADMGEML
CCCCHHEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREMRGISAETGLIGDIRGRGAMIAAELVVPGTDSPNREAVIQILKYCQDNGVLVLSAGT
HHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
YGNVLRFLPPLSMPDELLQEALAVLRDAFRNL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSVYSLQGGPAVAQVRRMATEVPGPRSRELAERRAAALPAGLVSGAGVYAAAAGGGVLV
CCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEEE
DVDGNSFLDLGSGIAVTTVGNSAPAVVARVAAQAQRFTHTCFLATPYEQYLEVAETLNRI
EECCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHC
TPGDHEKRTALFNTGAEAVENAVKYARVATARPAVVVFDHAFHGRSLMTMTMTAKQAPYR
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEHHHHCCCC
RGFGPFAPEVYRAPMAHPYRWPSGAENCASDAFRQFASLVDNQIGAEAVACVVVEPIQGE
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEECCC
GGFIVPAPGFLAMVADFCRARGILLVADEVQTGIARTGAWFASEHEQLVPDLVTTAKGLA
CCEEECCCHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
GGLPLAAVTGRADVMDAAHPGGIGGTFSGNPLSCAAALGVFEEIETHDLLRRAADMGEML
CCCCHHEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREMRGISAETGLIGDIRGRGAMIAAELVVPGTDSPNREAVIQILKYCQDNGVLVLSAGT
HHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
YGNVLRFLPPLSMPDELLQEALAVLRDAFRNL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]