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The map label for this gene is fabG [C]

Identifier: 169627864

GI number: 169627864

Start: 763205

End: 764062

Strand: Reverse

Name: fabG [C]

Synonym: MAB_0763c

Alternate gene names: 169627864

Gene position: 764062-763205 (Counterclockwise)

Preceding gene: 169627865

Following gene: 169627862

Centisome position: 15.08

GC content: 63.05

Gene sequence:

>858_bases
ATGCCCGGCACTCCGAAAACGGTGGTCATCACCGGCGCGAACGCCGGGATCGGTCTGGCCTCGGCGCATCGACTCGCCGC
CGGCGGGCACTCCATCGTCATGGCATGCCGCAATCAGCAGAAGGCTCAGCAGGCGCGGGATCAGATCCTGGCCGCGACAC
CGGGGGCTCAGATCGACATCATGTCGCTGGACCTGTCGTCCTTCGAACGCATTTATCGCTTCGCCGGCGAGCTGGCCGCA
CAGCATCCGCAGATCGACGTACTGGTCAACAACGCGGGCGCTTCCCCCATGCGCCAGTCCAAAACCGACGAGGGCTTCGA
ACTGCAATGGGGTGCGAACTATCTGGGCCCCTTTCTGCTGACGCATCTGCTGCTTCCGCAGCTGCAAGCCTCCCGAAGCG
GAGACGCCCGCGTGATCCATCTGGCCTCCGTCGCCCACAGCGTAGGAAGGATCAACGAAAAGACTTGGCACGGTAGACGT
TTTTACTTCACCTTCTCGGCGTACGCGCAGTCGAAGATGGGCAATCTCATGTTCAGCAATGCGCTGGCCCGCCGCCTTCC
CGATGGGGTGACCTCGAACGCACTGCACCCGGGCAACGTCAGATCGGAAATCTGGCGTGAGATACCACAGCCCGTCCGCT
CGCTGGTGATGCTGGCCCTGATCACGCCGGAGCGGCCAAGCCAGCTGATCGCCGATATGGCGGTATCGGAAGAGCACCGT
GGGCGCAATGGCGACTACCTCGCCGCACAAACGCCAAGCCCGGTACGCCGCTACACGAAAAACCTAGCGGCACAAGATAA
CCTCTACGCTAAGAGCTGTGCGCTGGTGGGCGTCGAGCCGCTGCCCGTACGCGGCTAA

Upstream 100 bases:

>100_bases
TGCGAGCCCTGCGCCTTGTGTGGCAGGCCTGGGCTCGACACCCCGCAAGTGCCGTGTGAGACTTCTCGGTGTTCTGGACG
TCTCGATGAGGAGATTCAGT

Downstream 100 bases:

>100_bases
GCCCAGCTCAGCCGACGATCGGCCTCGACGGCGAGATGGAGTTCAGCGATGTCGCGCGGCCGGGCGACATCACGCCCGGT
CAATTGTTTTAGCCTGCGCA

Product: oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPGTPKTVVITGANAGIGLASAHRLAAGGHSIVMACRNQQKAQQARDQILAATPGAQIDIMSLDLSSFERIYRFAGELAA
QHPQIDVLVNNAGASPMRQSKTDEGFELQWGANYLGPFLLTHLLLPQLQASRSGDARVIHLASVAHSVGRINEKTWHGRR
FYFTFSAYAQSKMGNLMFSNALARRLPDGVTSNALHPGNVRSEIWREIPQPVRSLVMLALITPERPSQLIADMAVSEEHR
GRNGDYLAAQTPSPVRRYTKNLAAQDNLYAKSCALVGVEPLPVRG

Sequences:

>Translated_285_residues
MPGTPKTVVITGANAGIGLASAHRLAAGGHSIVMACRNQQKAQQARDQILAATPGAQIDIMSLDLSSFERIYRFAGELAA
QHPQIDVLVNNAGASPMRQSKTDEGFELQWGANYLGPFLLTHLLLPQLQASRSGDARVIHLASVAHSVGRINEKTWHGRR
FYFTFSAYAQSKMGNLMFSNALARRLPDGVTSNALHPGNVRSEIWREIPQPVRSLVMLALITPERPSQLIADMAVSEEHR
GRNGDYLAAQTPSPVRRYTKNLAAQDNLYAKSCALVGVEPLPVRG
>Mature_284_residues
PGTPKTVVITGANAGIGLASAHRLAAGGHSIVMACRNQQKAQQARDQILAATPGAQIDIMSLDLSSFERIYRFAGELAAQ
HPQIDVLVNNAGASPMRQSKTDEGFELQWGANYLGPFLLTHLLLPQLQASRSGDARVIHLASVAHSVGRINEKTWHGRRF
YFTFSAYAQSKMGNLMFSNALARRLPDGVTSNALHPGNVRSEIWREIPQPVRSLVMLALITPERPSQLIADMAVSEEHRG
RNGDYLAAQTPSPVRRYTKNLAAQDNLYAKSCALVGVEPLPVRG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=298, Percent_Identity=37.5838926174497, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI166795268, Length=286, Percent_Identity=34.965034965035, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI186928839, Length=288, Percent_Identity=36.8055555555556, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI10190746, Length=263, Percent_Identity=36.1216730038023, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI7706523, Length=206, Percent_Identity=39.3203883495146, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI193804850, Length=286, Percent_Identity=32.8671328671329, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI19923931, Length=259, Percent_Identity=35.5212355212355, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI146231950, Length=288, Percent_Identity=35.0694444444444, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI7705421, Length=261, Percent_Identity=26.0536398467433, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI72534732, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI13375997, Length=163, Percent_Identity=28.8343558282209, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=215, Percent_Identity=26.5116279069767, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=256, Percent_Identity=33.59375, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193207620, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17532805, Length=216, Percent_Identity=32.8703703703704, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71992402, Length=212, Percent_Identity=30.188679245283, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532791, Length=222, Percent_Identity=29.2792792792793, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17505416, Length=256, Percent_Identity=25.78125, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32565532, Length=206, Percent_Identity=30.0970873786408, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI72001364, Length=192, Percent_Identity=32.2916666666667, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535059, Length=214, Percent_Identity=28.5046728971963, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17540960, Length=233, Percent_Identity=26.1802575107296, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324820, Length=234, Percent_Identity=31.1965811965812, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323882, Length=206, Percent_Identity=31.0679611650485, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553409, Length=287, Percent_Identity=35.5400696864112, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647948, Length=287, Percent_Identity=35.5400696864112, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647946, Length=287, Percent_Identity=35.5400696864112, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI22024069, Length=287, Percent_Identity=34.1463414634146, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19921754, Length=294, Percent_Identity=34.0136054421769, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI28573296, Length=207, Percent_Identity=40.5797101449275, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45554248, Length=275, Percent_Identity=34.1818181818182, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640117, Length=275, Percent_Identity=34.1818181818182, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24586328, Length=206, Percent_Identity=39.8058252427184, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI161076371, Length=254, Percent_Identity=35.4330708661417, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24656154, Length=282, Percent_Identity=32.9787234042553, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI19922628, Length=282, Percent_Identity=32.9787234042553, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129347, Length=206, Percent_Identity=33.495145631068, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24647931, Length=220, Percent_Identity=37.7272727272727, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571526, Length=204, Percent_Identity=28.921568627451, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357041, Length=206, Percent_Identity=29.126213592233, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358495, Length=210, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24643142, Length=227, Percent_Identity=27.7533039647577, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31011; Mature: 30880

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTPKTVVITGANAGIGLASAHRLAAGGHSIVMACRNQQKAQQARDQILAATPGAQIDI
CCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHEEEECCCCEEEE
MSLDLSSFERIYRFAGELAAQHPQIDVLVNNAGASPMRQSKTDEGFELQWGANYLGPFLL
EECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCEEEEECCHHHHHHHH
THLLLPQLQASRSGDARVIHLASVAHSVGRINEKTWHGRRFYFTFSAYAQSKMGNLMFSN
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
ALARRLPDGVTSNALHPGNVRSEIWREIPQPVRSLVMLALITPERPSQLIADMAVSEEHR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GRNGDYLAAQTPSPVRRYTKNLAAQDNLYAKSCALVGVEPLPVRG
CCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCC
>Mature Secondary Structure 
PGTPKTVVITGANAGIGLASAHRLAAGGHSIVMACRNQQKAQQARDQILAATPGAQIDI
CCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHEEEECCCCEEEE
MSLDLSSFERIYRFAGELAAQHPQIDVLVNNAGASPMRQSKTDEGFELQWGANYLGPFLL
EECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCEEEEECCHHHHHHHH
THLLLPQLQASRSGDARVIHLASVAHSVGRINEKTWHGRRFYFTFSAYAQSKMGNLMFSN
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
ALARRLPDGVTSNALHPGNVRSEIWREIPQPVRSLVMLALITPERPSQLIADMAVSEEHR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GRNGDYLAAQTPSPVRRYTKNLAAQDNLYAKSCALVGVEPLPVRG
CCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]