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The map label for this gene is dfrA [H]

Identifier: 169627819

GI number: 169627819

Start: 719890

End: 720861

Strand: Reverse

Name: dfrA [H]

Synonym: MAB_0718c

Alternate gene names: 169627819

Gene position: 720861-719890 (Counterclockwise)

Preceding gene: 169627824

Following gene: 169627817

Centisome position: 14.23

GC content: 64.92

Gene sequence:

>972_bases
ATGAAGACTGCCGTCACCGGAGCCGCCGGCTTCATTGGTACCAACCTAGTCAATCTGCTCGTGGATAACGGCCACGAGGT
GATCGCCATCGACCGGGTGGTGCCCGCCTCGCCGGAGACTCGCGAGGCCGTGACCTGGGTCTCTGGCGACGTCCTCGACC
CCGACTCGATGACGAAGGCGCTCGACGGCGTCGAGGTGGTTTACCACTTGGTGGCCGTTATCACCCTCAAGCACGAAGAC
GAGCTGTGCTGGCGGATCAACACCGAAGGTGCCCGCACCGTCGCACAGGCCGCCCTGACCGTGGGGGCCCGCCGCATGGT
GCACTGCAGCTCGATTGACTCCTACTCCAACAGCGTGGCCACCATCGACGAGAAGTCGCCACGCTCCGCGGCTGCCGACC
TGCCTGTCTATCAACGCTCCAAGTGGGGTGGCGAGGTGGCGGTACGCGAGACCATCGCGTCCGGACTGGATGCCGTGATC
TGCAACCCCACCGGCGTCTACGGTCCGGTCGATCTGCCCAATCTGTCACGCATCAACCAACTGCTGTTCGATAGCGCCCG
GGGCAGGCTGCCCGGGATGGTCAACAGTCAGTACGACCTGGTCGACGCCCGGGATGTCGCTGCCGGGCTCTACCTAGCCG
GCGAAAAGGGACGCACCGGCGAGAACTATCTCCTCGGTGGCCACATGGGGAGCCTGTTGCAGGTGTGCCGACTGGCCGCT
CGGCGCGCCGGCAAGCGCGGCCCGCGGTTCGCCGTGCCCATGGGCCTCCTCAACGCGGCCATCCCGGTCATCGAGCCGAT
CGGCAAGCTACTCAAGAACGACGCGTTGAGCCGGGCAGCGTTCAACAAGCTGACGGTTTCACCGGCGGTGGATATCACCA
AGGCCCGTACCGAATTGGGCTATGAGCCGCGGTCGACAGAAACCACCGTCAACGAGTTCGTGGACTTTCTTCTGGGCTCC
GGCCGGCTTTAA

Upstream 100 bases:

>100_bases
ACAACGCCAACCAAGCGAGCGTTAGGTAGGTTGGTTGCGATGCTGCCGGTCGCGCACGCGCCCCGGCGGTTATGACACCC
GAGCCAGCCAAGGGACAAAG

Downstream 100 bases:

>100_bases
ATCCCGACCATCGCGGCGCTGGCGCGCCATAGTCCGTCGGCCGCTCGGTCGTCCCGGGCCAGCGGGGCTGGATCCGGGAA
GGTCAGCTGCCCCTTCACAA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLKHED
ELCWRINTEGARTVAQAALTVGARRMVHCSSIDSYSNSVATIDEKSPRSAAADLPVYQRSKWGGEVAVRETIASGLDAVI
CNPTGVYGPVDLPNLSRINQLLFDSARGRLPGMVNSQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMGSLLQVCRLAA
RRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGS
GRL

Sequences:

>Translated_323_residues
MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLKHED
ELCWRINTEGARTVAQAALTVGARRMVHCSSIDSYSNSVATIDEKSPRSAAADLPVYQRSKWGGEVAVRETIASGLDAVI
CNPTGVYGPVDLPNLSRINQLLFDSARGRLPGMVNSQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMGSLLQVCRLAA
RRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGS
GRL
>Mature_323_residues
MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWVSGDVLDPDSMTKALDGVEVVYHLVAVITLKHED
ELCWRINTEGARTVAQAALTVGARRMVHCSSIDSYSNSVATIDEKSPRSAAADLPVYQRSKWGGEVAVRETIASGLDAVI
CNPTGVYGPVDLPNLSRINQLLFDSARGRLPGMVNSQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMGSLLQVCRLAA
RRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDITKARTELGYEPRSTETTVNEFVDFLLGS
GRL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI239745448, Length=335, Percent_Identity=25.6716417910448, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310132178, Length=335, Percent_Identity=25.6716417910448, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI310113012, Length=335, Percent_Identity=25.6716417910448, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71987463, Length=343, Percent_Identity=24.4897959183673, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 34509; Mature: 34509

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWVSGDVLDPDSMTKA
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHH
LDGVEVVYHLVAVITLKHEDELCWRINTEGARTVAQAALTVGARRMVHCSSIDSYSNSVA
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEHHCCHHHCCCEE
TIDEKSPRSAAADLPVYQRSKWGGEVAVRETIASGLDAVICNPTGVYGPVDLPNLSRINQ
ECCCCCCCCHHCCCCCHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHH
LLFDSARGRLPGMVNSQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMGSLLQVCRLAA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
RRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDITKARTELG
HHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCC
YEPRSTETTVNEFVDFLLGSGRL
CCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTAVTGAAGFIGTNLVNLLVDNGHEVIAIDRVVPASPETREAVTWVSGDVLDPDSMTKA
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHH
LDGVEVVYHLVAVITLKHEDELCWRINTEGARTVAQAALTVGARRMVHCSSIDSYSNSVA
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEHHCCHHHCCCEE
TIDEKSPRSAAADLPVYQRSKWGGEVAVRETIASGLDAVICNPTGVYGPVDLPNLSRINQ
ECCCCCCCCHHCCCCCHHCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHH
LLFDSARGRLPGMVNSQYDLVDARDVAAGLYLAGEKGRTGENYLLGGHMGSLLQVCRLAA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
RRAGKRGPRFAVPMGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDITKARTELG
HHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCC
YEPRSTETTVNEFVDFLLGSGRL
CCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]