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The map label for this gene is aqpZ [H]

Identifier: 169627692

GI number: 169627692

Start: 590474

End: 591232

Strand: Direct

Name: aqpZ [H]

Synonym: MAB_0589

Alternate gene names: 169627692

Gene position: 590474-591232 (Clockwise)

Preceding gene: 169627690

Following gene: 169627694

Centisome position: 11.65

GC content: 61.66

Gene sequence:

>759_bases
ATGAGTAAGACGAGTACTAAATTGCTGGCCGAGTTATTCGGCACGTTCTGGCTGGTTTTTGGCGGCTGTGGCAGCGCGAT
TTTTGCGGCGAAGAATGTCGCGGATGCAGGAGAAGGAAACGCGGGTGCCATTCAATTGGGCATCGGCTTTCTCGGAGTGG
CACTGGCGTTCGGGTTGACCGTGGTGACAATGGCTTACGCGGTTGGTCACATTTCGGGCGGGCATTTCAATCCGGCGGTC
ACACTGGGTGCGGTGGCCGGTGGGCGTCTGCCCGCCAAGGAGCTTCCCGGATACTGGGTGGCGCAGGTGCTCGGCGGGCT
GCTCGCGGGCACCGCGTTGTGGTACATCGCGCGCGGTAAGCCGGGCTTTGAAGCGACCGGAAACATGGCGGCCAACGGCT
ACGGCGAGCACTCGCCCAATCACTACTCGTTGGCGGCGGTGTTGGTCACAGAGATCGTGCTCACGGCGGTGTTCATCATG
GTCATTTTGGGTGCCACCGATGCGGGTGCGCCCAAGGGTTTCGGCCCGTTGGCAATCGGCTTGTGTCTCACACTGATTCA
CTTGATTTCGATTCCGATCAGCAATACGTCGGTGAACCCGGCGCGGTCGACCGCTGTCGCCTTCTTCAACGGTGGTGCGG
CGCCAGGGCAGCTGTGGCTGTTTTGGGTGGCACCGCTGATCGGCGGTCTGATCGGCGGCCTGCTGTACCCGTTCTTGTTC
GACAACAGCAGGTTGGTGGCCGAGGCGGCGCAGGACTGA

Upstream 100 bases:

>100_bases
TTCGTGACACAACTGTTTCTGATAAGTGGCTGTGTGTTTGGGTCCAGCATTGGTAGTAATCAGGATCATGTGAGTTCTTA
CGAAACGAAGGGATCCGACG

Downstream 100 bases:

>100_bases
ACGCGCCCCGAACACGCTAGCCGTACCAGCGCCTAGCGTGTTCGGCGTGCGTCGGCAGGTAGGCGCCGGGACCGAAGTAG
GTGTCGTAGAAGCCCAAGTC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSKTSTKLLAELFGTFWLVFGGCGSAIFAAKNVADAGEGNAGAIQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAV
TLGAVAGGRLPAKELPGYWVAQVLGGLLAGTALWYIARGKPGFEATGNMAANGYGEHSPNHYSLAAVLVTEIVLTAVFIM
VILGATDAGAPKGFGPLAIGLCLTLIHLISIPISNTSVNPARSTAVAFFNGGAAPGQLWLFWVAPLIGGLIGGLLYPFLF
DNSRLVAEAAQD

Sequences:

>Translated_252_residues
MSKTSTKLLAELFGTFWLVFGGCGSAIFAAKNVADAGEGNAGAIQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAV
TLGAVAGGRLPAKELPGYWVAQVLGGLLAGTALWYIARGKPGFEATGNMAANGYGEHSPNHYSLAAVLVTEIVLTAVFIM
VILGATDAGAPKGFGPLAIGLCLTLIHLISIPISNTSVNPARSTAVAFFNGGAAPGQLWLFWVAPLIGGLIGGLLYPFLF
DNSRLVAEAAQD
>Mature_251_residues
SKTSTKLLAELFGTFWLVFGGCGSAIFAAKNVADAGEGNAGAIQLGIGFLGVALAFGLTVVTMAYAVGHISGGHFNPAVT
LGAVAGGRLPAKELPGYWVAQVLGGLLAGTALWYIARGKPGFEATGNMAANGYGEHSPNHYSLAAVLVTEIVLTAVFIMV
ILGATDAGAPKGFGPLAIGLCLTLIHLISIPISNTSVNPARSTAVAFFNGGAAPGQLWLFWVAPLIGGLIGGLLYPFLFD
NSRLVAEAAQD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=235, Percent_Identity=34.0425531914894, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4502179, Length=247, Percent_Identity=32.7935222672065, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI6912506, Length=244, Percent_Identity=34.8360655737705, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4502183, Length=244, Percent_Identity=33.6065573770492, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI4502181, Length=197, Percent_Identity=30.9644670050761, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4755125, Length=197, Percent_Identity=30.9644670050761, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI157266307, Length=277, Percent_Identity=29.6028880866426, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI45446752, Length=196, Percent_Identity=35.2040816326531, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4826645, Length=254, Percent_Identity=29.9212598425197, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4502187, Length=256, Percent_Identity=28.90625, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI86792455, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787101, Length=219, Percent_Identity=66.2100456621005, Blast_Score=264, Evalue=5e-72,
Organism=Escherichia coli, GI1790362, Length=270, Percent_Identity=27.037037037037, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993722, Length=248, Percent_Identity=29.4354838709677, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558372, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992966, Length=257, Percent_Identity=27.6264591439689, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652747, Length=245, Percent_Identity=33.8775510204082, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551084, Length=245, Percent_Identity=33.8775510204082, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24652751, Length=236, Percent_Identity=33.8983050847458, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922038, Length=236, Percent_Identity=33.8983050847458, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550503, Length=258, Percent_Identity=25.968992248062, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136672, Length=203, Percent_Identity=32.512315270936, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25645; Mature: 25514

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTSTKLLAELFGTFWLVFGGCGSAIFAAKNVADAGEGNAGAIQLGIGFLGVALAFGLT
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
VVTMAYAVGHISGGHFNPAVTLGAVAGGRLPAKELPGYWVAQVLGGLLAGTALWYIARGK
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHEECCC
PGFEATGNMAANGYGEHSPNHYSLAAVLVTEIVLTAVFIMVILGATDAGAPKGFGPLAIG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LCLTLIHLISIPISNTSVNPARSTAVAFFNGGAAPGQLWLFWVAPLIGGLIGGLLYPFLF
HHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DNSRLVAEAAQD
CCCHHHHCCCCC
>Mature Secondary Structure 
SKTSTKLLAELFGTFWLVFGGCGSAIFAAKNVADAGEGNAGAIQLGIGFLGVALAFGLT
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
VVTMAYAVGHISGGHFNPAVTLGAVAGGRLPAKELPGYWVAQVLGGLLAGTALWYIARGK
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHEECCC
PGFEATGNMAANGYGEHSPNHYSLAAVLVTEIVLTAVFIMVILGATDAGAPKGFGPLAIG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LCLTLIHLISIPISNTSVNPARSTAVAFFNGGAAPGQLWLFWVAPLIGGLIGGLLYPFLF
HHHHHHHHHHCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DNSRLVAEAAQD
CCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]