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The map label for this gene is copA [H]

Identifier: 169627567

GI number: 169627567

Start: 462397

End: 463935

Strand: Reverse

Name: copA [H]

Synonym: MAB_0463c

Alternate gene names: 169627567

Gene position: 463935-462397 (Counterclockwise)

Preceding gene: 169627573

Following gene: 169627566

Centisome position: 9.16

GC content: 68.36

Gene sequence:

>1539_bases
ATGGCGGTGTCGCGATCGCAATGGGGTCGGCGCGGGTTCTTGCAGCTGGGTGCGGCCACCGCGGCGGCCGGGGTGCTGGC
CGCCTGCGGCACGCGGCCGGTGCGCGGGCCCAGCGGGCAGCCGGTGGGGCCGAGCTCACCGAGAGTGGGCGCGCTCGAAG
CGGTCCGCCGCGACGGGGGCGGCCGATTGGTGCCGGTGAATTTGGCCGCGCGGCCGCTGCAGCTGGATCTGGCCGGCACG
ACCGTTTCCACGTGGGGTTATGGCGACCAGATTCCCGGGCCCACGATCCGGGCCCGCAAGGGCGAGGTGCTGCGGGTGGC
CGTGGCCAATGGGCTGCCGGCGCCCACCACGGTGCACTGGCATGGGATCGCGTTGCGCAACGACATGGACGGGGTGCCGG
ATCTGACGCAGCCGCAGATCGCGGCAGCGGGATCGTTCACCTACGAATTCGCCCTGGCCCACGCGGGCACGTACTGGTTT
CATCCGCATGTGGGCACCCAGCTGGATCGGGGTCTGTATGCGCCGCTGATCGTGGAAGACCCCGATGAGCGCGCCGACTA
CGACACCGAACTGGTCGTGGCACTCGATGACTGGATCGATGGCACCGGCACCGACCCCGACAAAGTATTGGCCGGGCTCC
GGGACAAAGGCATGCCCGGGATGGGGCACTCGATGGGCGATATGCCGGGGATGTCGATTGGTTCGATGGGCGTCAGTGCG
CAGGCGCCTCTCGGGGCCGACGGCGGCGACGTCACCTACCCGTACTACCTGATCAACGGGCGGGTGGCCGCCGATCCGCA
GAGCGTCGACTACCGGCCCGGGACCCGGGTGCGGCTGCGGATCATCAACGCCGCCGGCGACAGCGCATTTCGGGTCGCGA
TCCCCGGGACACCGCTGACGGTGACTCACACCGACGGCTTCCCCGTGCAGCCGCGGCAAACCGATGCACTGCTGATCGGT
ATGGGTGAGCGCATCGATGCCATCATCACTGTCGGTGAGGTCTCGGTGCCGCTGCTGGCAGCCCCCTACGGCAAGGACGG
CTACGCCCAGTTGGTCCTGCGCTCGAGCGGCACACCCGTGTCCGGTTCGGCCGCCGAGGCGGCCGCGGCGCTACCGAAGC
TGGCGGCATTAGACACCGCGTCCCTGAGCGCCACTGAGGAGGTCACGCTGGCTGTCGGTGAACCCGACATCACCTACGAT
CTGCGCCTGGCGGGGCCGGGCAACAAATACTCCTGGACGATCAACGAGAAAACCTACAACCCGGCCGAGGGGCTGCCGGT
GCGCGAGGGCCAGCGGGTGCGGCTGCGCTTCATCAACAACTCCATGATGTTTCACCCGATGCACCTGCACGGGCACACCT
TCGCCGTGCGGACCGCATCCGGGGCCTACGGCGCCCGCAAAGACACCGTGCTGGTGGCACCCATGCAGACCGTCGAAGTC
GACTTCGATGCGGATAACCCGGGCCAGTGGCTGACCCACTGCCACAACATTTATCACGGCGAAGCCGGAATGATGACCGT
CGTCTCCTACCGCCAATAG

Upstream 100 bases:

>100_bases
GTTCACCATAACATGATGTGCGCATACCCTTACCCGGTATTTGACATGTGTTTTCCGCAGCTGACTCAGGCGGCATGAAA
GGACATGAAAGGAGCGGTTC

Downstream 100 bases:

>100_bases
CCCTGAACACCAAAGGTGTCGCTGCCCGGCCATCGGTGTCGATCAGCGGGAAAGTGCCATCGACTACACGACTACGCATA
AGGAGATCACCATGGGTGCA

Product: oxidase (copper-binding protein)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MAVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGGGRLVPVNLAARPLQLDLAGT
TVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWF
HPHVGTQLDRGLYAPLIVEDPDERADYDTELVVALDDWIDGTGTDPDKVLAGLRDKGMPGMGHSMGDMPGMSIGSMGVSA
QAPLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLTVTHTDGFPVQPRQTDALLIG
MGERIDAIITVGEVSVPLLAAPYGKDGYAQLVLRSSGTPVSGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPDITYD
LRLAGPGNKYSWTINEKTYNPAEGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRTASGAYGARKDTVLVAPMQTVEV
DFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ

Sequences:

>Translated_512_residues
MAVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGGGRLVPVNLAARPLQLDLAGT
TVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWF
HPHVGTQLDRGLYAPLIVEDPDERADYDTELVVALDDWIDGTGTDPDKVLAGLRDKGMPGMGHSMGDMPGMSIGSMGVSA
QAPLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLTVTHTDGFPVQPRQTDALLIG
MGERIDAIITVGEVSVPLLAAPYGKDGYAQLVLRSSGTPVSGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPDITYD
LRLAGPGNKYSWTINEKTYNPAEGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRTASGAYGARKDTVLVAPMQTVEV
DFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ
>Mature_511_residues
AVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGGGRLVPVNLAARPLQLDLAGTT
VSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWFH
PHVGTQLDRGLYAPLIVEDPDERADYDTELVVALDDWIDGTGTDPDKVLAGLRDKGMPGMGHSMGDMPGMSIGSMGVSAQ
APLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLTVTHTDGFPVQPRQTDALLIGM
GERIDAIITVGEVSVPLLAAPYGKDGYAQLVLRSSGTPVSGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPDITYDL
RLAGPGNKYSWTINEKTYNPAEGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRTASGAYGARKDTVLVAPMQTVEVD
FDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=498, Percent_Identity=24.6987951807229, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323703, Length=473, Percent_Identity=26.215644820296, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320714, Length=487, Percent_Identity=23.4086242299795, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321067, Length=502, Percent_Identity=22.1115537848606, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221330000, Length=267, Percent_Identity=28.4644194756554, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585842, Length=267, Percent_Identity=28.4644194756554, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281360167, Length=267, Percent_Identity=28.4644194756554, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221329998, Length=267, Percent_Identity=28.4644194756554, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859919, Length=255, Percent_Identity=26.2745098039216, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650186, Length=319, Percent_Identity=24.4514106583072, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28574104, Length=123, Percent_Identity=35.7723577235772, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54182; Mature: 54051

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGG
CCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
GRLVPVNLAARPLQLDLAGTTVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHW
CEEEEEECCCCEEEEEEECCEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCCCEEEE
HGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWFHPHVGTQLDRGLYAPLIVED
EEEEEECCCCCCCCCCCCCEEECCCEEEEEEEECCCEEEECCCCCCHHCCCCCCCEEEEC
PDERADYDTELVVALDDWIDGTGTDPDKVLAGLRDKGMPGMGHSMGDMPGMSIGSMGVSA
CCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
QAPLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLT
CCCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEE
VTHTDGFPVQPRQTDALLIGMGERIDAIITVGEVSVPLLAAPYGKDGYAQLVLRSSGTPV
EEECCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCCCC
SGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPDITYDLRLAGPGNKYSWTINEKTYN
CCCHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCC
PAEGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRTASGAYGARKDTVLVAPMQTVEV
CCCCCCCCCCCEEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCCEEEEECCEEEEE
DFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ
EECCCCCHHHHHHHHHHEECCCCEEEEEEECC
>Mature Secondary Structure 
AVSRSQWGRRGFLQLGAATAAAGVLAACGTRPVRGPSGQPVGPSSPRVGALEAVRRDGG
CCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
GRLVPVNLAARPLQLDLAGTTVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHW
CEEEEEECCCCEEEEEEECCEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCCCEEEE
HGIALRNDMDGVPDLTQPQIAAAGSFTYEFALAHAGTYWFHPHVGTQLDRGLYAPLIVED
EEEEEECCCCCCCCCCCCCEEECCCEEEEEEEECCCEEEECCCCCCHHCCCCCCCEEEEC
PDERADYDTELVVALDDWIDGTGTDPDKVLAGLRDKGMPGMGHSMGDMPGMSIGSMGVSA
CCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
QAPLGADGGDVTYPYYLINGRVAADPQSVDYRPGTRVRLRIINAAGDSAFRVAIPGTPLT
CCCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEE
VTHTDGFPVQPRQTDALLIGMGERIDAIITVGEVSVPLLAAPYGKDGYAQLVLRSSGTPV
EEECCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCCCC
SGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPDITYDLRLAGPGNKYSWTINEKTYN
CCCHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCC
PAEGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRTASGAYGARKDTVLVAPMQTVEV
CCCCCCCCCCCEEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCCEEEEECCEEEEE
DFDADNPGQWLTHCHNIYHGEAGMMTVVSYRQ
EECCCCCHHHHHHHHHHEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]