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The map label for this gene is crp [H]

Identifier: 169627520

GI number: 169627520

Start: 416506

End: 417180

Strand: Reverse

Name: crp [H]

Synonym: MAB_0416c

Alternate gene names: 169627520

Gene position: 417180-416506 (Counterclockwise)

Preceding gene: 169627521

Following gene: 169627515

Centisome position: 8.23

GC content: 67.26

Gene sequence:

>675_bases
GTGGACGAGATCCTGGCCAGGGCCGGAATCTTCCAGGGTGTCGAACCGAGCGCCGTCTCGGCGCTGACCAAGCAGCTACA
GCCGGTTGACTTTCCGCGCGGACACACGGTGTTCGCCGAAGGCGAGCCTGGCGACCGTCTGTACATCATCATCACCGGCA
AGGTGAAGATCGGGCGCCGATCACCCGATGGCCGTGAGAACCTACTGACGATCATGGGCCCGTCGGACATGTTCGGTGAG
CTGTCGATCTTCGACCCCGGCCCCCGGACGTCGAGCGCCACCACCATCACCGAGGTGCGTGCCGTGTCGATGGACCGGGA
CGCACTGCGCGCCTGGATCGCCGACCGCCCGGAGATCGCCGAGCAGCTGCTGCGCGTCTTGGCCCGCCGCCTGCGCCGCA
CCAACAACAATCTCGCCGATTTGATCTTCACCGATGTGCCCGGCCGCGTGGCCAAGCAACTGCTGCAGCTGGCTCAGCGG
TTCGGCACCCAGGAGGGTGGCGCGCTCCGCGTGACGCACGACCTGACGCAGGAAGAGATCGCCCAGCTGGTAGGTGCGTC
CCGCGAGACCGTGAACAAGGCCCTGGCCGATTTCGCGCACCGCGGCTGGATCCGCCTGGAGGGCAAGAGCGTCCTGATCT
CGGACTCCGAGCGTCTGGCACGCCGCGCGCGTTGA

Upstream 100 bases:

>100_bases
TGTAGCTTGGATCACGTTCTTTGGCGACCTGGCCTCTAGACTCATGTCGAGGCAAGCAGGCCTGCGCAAGCATGACTAAC
AATTTGGGTAAGGGGCAAAC

Downstream 100 bases:

>100_bases
TTTCCCGTGTATGTCAGCGCGCCGCGCTGAACACCACGACAGCTACGCACACAAGCGTCAGCACCGCACCGGTCTGTTGA
ACCCTGCTGAGGCGCTCATG

Product: Crp/Fnr family transriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MDEILARAGIFQGVEPSAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIITGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Sequences:

>Translated_224_residues
MDEILARAGIFQGVEPSAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIITGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
>Mature_224_residues
MDEILARAGIFQGVEPSAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIITGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI258613977, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI258613975, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI258613973, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI258613971, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI258613969, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI38257139, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789756, Length=189, Percent_Identity=32.2751322751323, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24792; Mature: 24792

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEILARAGIFQGVEPSAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIITGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCEEECCC
SPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIA
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEI
HHHHHHHHHHHHHCCCCCEEHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHH
AQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MDEILARAGIFQGVEPSAVSALTKQLQPVDFPRGHTVFAEGEPGDRLYIIITGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCEEECCC
SPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIA
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEI
HHHHHHHHHHHHHCCCCCEEHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHH
AQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]